Most-cited papers on Randomized Controlled Trials

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

   2002 · JAMA · Investigators, Writing Group for the Women's Health Initiative

   15,777 cited

2. A Randomized Trial of Intensive versus Standard Blood-Pressure Control

   2015 · New England Journal of Medicine · Group, The SPRINT Research

   6,184 cited

3. A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care

   1999 · New England Journal of Medicine · Hébert, Paul C., Wells, George A., Blajchman, Morris A. et al.

   5,207 cited

4. Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials

   2003 · Physical Therapy · Maher, Christopher G., Sherrington, Catherine, Herbert, Rob et al.

   4,701 cited

5. Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs

   2000 · New England Journal of Medicine · Concato, John, Shah, Nirav R., Horwitz, Ralph I.

   3,528 cited

6. A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy

   2001 · New England Journal of Medicine · Wiebe, Samuel, Blume, Warren T., Girvin, John P. et al.

   3,478 cited

7. Cognitive Stimulation in Patients with Dementia: Randomized Controlled Trial

   2013 · Dementia and Geriatric Cognitive Disorders Extra · Mapelli, Daniela, Rosa, Elisa Di, Nocita, Rosaria et al.

   3,465 cited

8. Improving the quality of reporting of randomized controlled trials. The CONSORT statement

   1996 · JAMA · Begg, Colin B.

   3,353 cited

9. A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

   2006 · New England Journal of Medicine · Polman, Chris H., O’Connor, Paul, Havrdová, Eva et al.

   3,327 cited

10. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

    2001 · Archives of Ophthalmology · Group, Age-Related Eye Disease Study Research

    3,241 cited

11. Improving the Quality of Reporting of Randomized Controlled Trials

    1996 · JAMA · Begg, Colin B.

    3,132 cited

12. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

    1990 · New England Journal of Medicine · Bracken, Michael B., Shepard, M J, Collins, William F. et al.

    2,729 cited

13. Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial

    2015 · Journal of Clinical Oncology · Basch, Ethan, Deal, Allison M., Kris, Mark G. et al.

    2,623 cited

14. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

    2002 · Hepatology · Lo, Chung‐Mau, Ngan, Hys, Tso, Wai‐Kuen et al.

    2,617 cited

15. Randomized, Controlled Trial of an Intervention for Toddlers With Autism: The Early Start Denver Model

    2009 · PEDIATRICS · Dawson, Géraldine, Rogers, Sally J., Munson, Jeffrey et al.

    2,548 cited

16. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

    2015 · New England Journal of Medicine · Pi‐Sunyer, F. Xavier, Astrup, Arne, Fujioka, Ken et al.

    2,538 cited

17. Effects of Atorvastatin on Early Recurrent Ischemic Events in Acute Coronary Syndromes<SUBTITLE>The MIRACL Study: A Randomized Controlled Trial</SUBTITLE>

    2001 · JAMA · Schwartz, Gregory G.

    2,485 cited

18. Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

    1999 · JAMA · Harris, Steven T.

    2,452 cited

19. Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

    2005 · PLoS Medicine · Auvert, Bertran, Taljaard, Dirk, Lagarde, Emmanuel et al.

    2,450 cited

20. Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial

    2017 · JMIR Mental Health · Fitzpatrick, Kathleen Kara, Darcy, Alison, Vierhile, Molly

    2,449 cited

21. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

    1996 · JAMA · Clark, L.

    2,406 cited

22. A Comparison of Observational Studies and Randomized, Controlled Trials

    2000 · New England Journal of Medicine · Benson, Kjell, Hartz, Arthur J.

    2,348 cited

23. A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer

    2003 · Journal of Clinical Oncology · Goldberg, Richard M., Sargent, Daniel J., Morton, Roscoe F. et al.

    2,266 cited

24. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials

    2004 · The American Journal of Medicine · Taylor, Rod S, Brown, Allan, Ebrahim, Shah et al.

    2,257 cited

25. A Pilot Study and Randomized Controlled Trial of the Mindful Self‐Compassion Program

    2012 · Journal of Clinical Psychology · Neff, Kristin D., Germer, Christopher K.

    2,154 cited

26. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials

    1997 · Journal of Clinical Epidemiology · Bucher, Heiner C., Guyatt, Gordon, Griffith, Lauren E. et al.

    2,037 cited

27. Two-Year Randomized Controlled Trial and Follow-up of Dialectical Behavior Therapy vs Therapy by Experts for Suicidal Behaviors and Borderline Personality Disorder

    2006 · Archives of General Psychiatry · Linehan, Marsha M., Comtois, Katherine Anne, Murray, Angela M. et al.

    1,993 cited

28. Computerized Training of Working Memory in Children With ADHD-A Randomized, Controlled Trial

    2005 · Journal of the American Academy of Child & Adolescent Psychiatry · Klingberg, Torkel, Fernell, Elisabeth, Olesen, Pernille J. et al.

    1,944 cited

29. Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial

    2007 · Biological Psychiatry · O’Reardon, John P., Solvason, H. Brent, Janicak, Philip G. et al.

    1,879 cited