Most-cited papers on Safety and Off target Effects

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. The urinary safety profile and secondary renal effects of retigabine (ezogabine): A first‐in‐class antiepileptic drug that targets KCNQ (K_v7) potassium channels

   2012 · Epilepsia · Brickel, Neil, Gandhi, Paul, VanLandingham, Kevan et al.

   72 cited

2. Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Celiac Disease: Safety, Pharmacokinetics, and Effects on Intestinal Histology and Plasma Cytokines with Escalating Dose Regimens of Nexvax2 in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

   2017 · EBioMedicine · Daveson, A. James M., Ee, Hooi C., Andrews, Jane M. et al.

   64 cited

3. Exploring the Effects of a Road Safety Advertising Campaign on the Perceptions and Intentions of the Target and Nontarget Audiences to Drink and Drive

   2002 · Traffic Injury Prevention · Tay, Richard

   62 cited

4. Effects of a Workplace Intervention Targeting Psychosocial Risk Factors on Safety and Health Outcomes

   2015 · BioMed Research International · Hammer, Leslie B., Truxillo, Donald M., Bodner, Todd et al.

   59 cited

5. Making great minds think alike: Emerging market multinational firms’ leadership effects on targets’ employee psychological safety after cross-border mergers and acquisitions

   2015 · International Business Review · Rao‐Nicholson, Rekha, Khan, Zaheer, Stokes, Peter

   53 cited

6. Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer

   2013 · Head & Neck · Strieth, Sebastian, Dunau, Christoph, Michaelis, Uwe et al.

   46 cited

7. A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke

   2009 · Stroke · Teal, Philip, Davis, Stephen M., Hacke, Werner et al.

   42 cited

8. Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

   2023 · Journal of the American Chemical Society · Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu et al.

   38 cited

9. The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma

   2020 · Science Translational Medicine · Lulla, Premal, Tzannou, Ifigeneia, Vasileiou, Spyridoula et al.

   36 cited

10. Psychological Safety Climate as a Human Resource Development Target: Effects on Workers Functioning Through Need Satisfaction and Thwarting

    2018 · Advances in Developing Human Resources · Huyghebaert‐Zouaghi, Tiphaine, Gillet, Nicolas, Lahiani, Fadi-Joseph et al.

    35 cited

11. Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers

    2022 · Current Opinion in Food Science · Wang, Dongxu, Wang, Taotao, Zhang, Zhihong et al.

    35 cited

12. Change detection in urban and rural driving scenes: Effects of target type and safety relevance on change blindness

    2017 · Accident Analysis & Prevention · Beanland, Vanessa, Filtness, Ashleigh, Jeans, Rhiannon

    31 cited

13. Effects of a Safety-Awareness–Promoting Program Targeting Mothers of Children Aged 0–6 Years to Prevent Pediatric Injuries in the Home Environment: Implications for Nurses

    2018 · Journal of Trauma Nursing · Kahrıman, İlknur, Karadeniz, Havva

    30 cited

14. Safety Effects of Targeted Program to Improve Skid Resistance

    2008 · Transportation Research Record Journal of the Transportation Research Board · Lyon, Craig, Persaud, Bhagwant

    27 cited

15. Vibrio cholerae CVD103-HgR live oral attenuated vaccine: construction, safety, immunogenicity, excretion and non-target effects.

    1995 · PubMed · Cryz, Stanley J., Kaper, James B., Tacket, Carol O. et al.

    25 cited

16. Holes in the safety net? Assessing the effects of targeted benefits upon the health care utilization of poor New Zealanders

    2000 · Health & Social Care in the Community · Barnett, John, Coyle, Philip, Kearns, Robin

    23 cited

17. Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies

    2022 · Alzheimer s & Dementia Translational Research & Clinical Interventions · Pagán, Fernando, Torres‐Yaghi, Yasar, Hebron, Michaeline et al.

    19 cited

18. Effects of Propofol Target-Controlled Infusion on Haemodynamic and Respiratory Changes with Regard to Safety

    2004 · Journal of International Medical Research · Lee, Yong Sup

    18 cited

19. Using transcriptome Shannon entropy to evaluate the off-target effects and safety of insecticidal siRNAs

    2022 · Journal of Integrative Agriculture · Ma, Weihua, Wu, Tong, ZHANG, Zan et al.

    18 cited

20. Environmental safety of entomopathogenic nematodes – Effects on abundance, diversity and community structure of non-target beetles in a forest ecosystem

    2012 · Biological Control · Dillon, Aoife B., Foster, Aileen, Williams, Christopher D. et al.

    17 cited

21. Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats

    2015 · Lab Animal · Cowan, Alan, Sarabia-Estrada, Rachel, Wilkerson, Gina et al.

    12 cited

22. Handling side-effects of targeted therapies: safety of targeted therapies in solid tumours

    2008 · Annals of Oncology · Elez, Élena, Macarulla, Teresa, Tabernero, Josep

    12 cited

23. Off-Target Effects and Safety Aspects of Phosphorothioate Oligonucleotides

    2012 · RNA technologies · Stessl, Martina, Noe, Christian R., Winkler, Johannes

    11 cited

24. C-X-C Motif Chemokine Receptor 4–Targeted Radioligand Therapy in Hematological Malignancies—Myeloablative Effects, Antilymphoma Activity, and Safety Profile

    2023 · Clinical Nuclear Medicine · Dreher, Niklas, Dörrler, Anna-Lena, Kraus, Sabrina et al.

    11 cited

25. Effects of the CMS’ Public Reporting Program for Inpatient Psychiatric Facilities on Targeted and Nontargeted Safety: Differences Between For-Profits and Nonprofits

    2021 · Medical Care Research and Review · Shields, Morgan C.

    10 cited

26. Assessment of Hsp90β-selective inhibitor safety and on-target effects

    2025 · Scientific Reports · Reynolds, Tyelor S., Mishra, Sanket J., Blagg, Brian S. J.

    10 cited

27. The Effects of Behavior-based Safety Techniques on Behavior Variation, Targeted and Non-Targeted Safe Behaviors, and Productivity and Quality in Manufacturing Facilities

    2006 · Godbey, Jessie

    8 cited

28. Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies

    2025 · OncoImmunology · Schindler-Wnek, Katharina, Stahringer, Anika, Heimer, Nadine et al.

    7 cited