Most-cited papers on cell lines cells cancer primary

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

   2014 · Cancer Research · Mouradov, Dmitri, Sloggett, Clare, Jorissen, Robert N. et al.

   397 cited

2. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

   2003 · PubMed · Reisman, David, Sciarrotta, Janiece, Wang, Weidong et al.

   390 cited

3. Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature

   2009 · BMC Cancer · Köhrmann, Andrea, Kämmerer, Ulrike, Kapp, Michaela et al.

   389 cited

4. Identification of Putative Stem Cell Markers, CD133 and CXCR4, in hTERT–Immortalized Primary Nonmalignant and Malignant Tumor-Derived Human Prostate Epithelial Cell Lines and in Prostate Cancer Specimens

   2007 · Cancer Research · Miki, Jun, Furusato, Bungo, Li, Hongzhen et al.

   364 cited

5. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

   1995 · PubMed · Shapiro, Geoffrey I., Edwards, Christian D., Kobzik, Lester et al.

   346 cited

6. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

   2001 · Human Molecular Genetics · Smiraglia, Dominic J.

   239 cited

7. Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.

   1990 · PubMed · Watson, Joanna M., Sensintaffar, John, Berek, Jonathan S. et al.

   224 cited

8. Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas

   2004 · Cancer Research · Douglas, Eleanor, Fiegler, Heike, Rowan, Andrew et al.

   192 cited

9. Growth‐inhibitory effect of quercetin and presence of type‐II estrogen‐binding sites in human colon‐cancer cell lines and primary colorectal tumors

   1992 · International Journal of Cancer · Ranelletti, Franco O., Ricci, Riccardo, Larocca, Luigi Maria et al.

   171 cited

10. Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

    2010 · Journal of Histochemistry & Cytochemistry · Yuan, Kun, Frolova, Natalya, Xie, Yi et al.

    159 cited

11. A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.

    2004 · Molecular Cancer · Lind, Guro E., Thorstensen, Lin, Løvig, T. et al.

    156 cited

12. Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors

    2000 · International Journal of Cancer · Ranelletti, Franco O., Maggiano, Nicola, Serra, Fabio et al.

    156 cited

13. Generation and genetic characterization of immortal human prostate epithelial cell lines derived from primary cancer specimens.

    1997 · PubMed · Bright, Robert K., Vocke, Cathy D., Emmert-Buck, M R et al.

    136 cited

14. Identification and Characterization of Cells with Cancer Stem Cell Properties in Human Primary Lung Cancer Cell Lines

    2013 · PLoS ONE · Wang, Ping, Gao, Quanli, Suo, Zhenhe et al.

    133 cited

15. Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines.

    1993 · PubMed · Hamaguchi, K, Godwin, Andrew K., Yakushiji, M et al.

    132 cited

16. Autocrine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro

    2005 · Angiogenesis · Weigand, Melanie, Hantel, Pia, Kreienberg, R. et al.

    132 cited

17. Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) type II receptor, bind, and are responsive to MIS.

    1999 · PubMed · Masiakos, Peter T., MacLaughlin, David T., Maheswaran, Shyamala et al.

    122 cited

18. Spermine Oxidase SMO(PAOh1), Not N1-Acetylpolyamine Oxidase PAO, Is the Primary Source of Cytotoxic H2O2 in Polyamine Analogue-treated Human Breast Cancer Cell Lines

    2005 · Journal of Biological Chemistry · Pledgie, Allison, Huang, Yi, Hacker, Amy et al.

    119 cited

19. Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.

    1993 · PubMed · Smith, K., Houlbrook, S, Greenall, Michael J. et al.

    112 cited

20. ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.

    2000 · PubMed · You, Liang, Yang, Cheng‐Ta, Jablons, David M.

    112 cited

21. Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue

    2010 · Current Opinion in Pharmacology · Cree, Ian A., Glaysher, Sharon, Harvey, Alan L.

    109 cited

22. Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors

    1998 · Breast Cancer Research and Treatment · Zapata, Juan M., Krajewska, Maryla, Krajewski, Stanisław et al.

    107 cited

23. Drug screening of cancer cell lines and human primary tumors using droplet microfluidics

    2017 · Scientific Reports · Wong, Ada Hang‐Heng, Li, Haoran, Jia, Yanwei et al.

    105 cited

24. The NK-1 Receptor Is Expressed in Human Primary Gastric and Colon Adenocarcinomas and Is Involved in the Antitumor Action of L-733,060 and the Mitogenic Action of Substance P on Human Gastrointestinal Cancer Cell Lines

    2008 · Tumor Biology · Rosso, Marisa, as, Mar iacute a Jose Robles-Fr iacute, as, Rafael Cove ntilde et al.

    99 cited

25. Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors

    1999 · Oncogene · Bilanges, Benoît, Varrault, Annie, Basyuk, Eugénia et al.

    99 cited

26. <i>BEX2</i> Is Overexpressed in a Subset of Primary Breast Cancers and Mediates Nerve Growth Factor/Nuclear Factor-κB Inhibition of Apoptosis in Breast Cancer Cell Lines

    2007 · Cancer Research · Naderi, Ali, Teschendorff, Andrew E., Beigel, Juergen et al.

    97 cited

27. Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines

    1999 · British Journal of Cancer · Sartor, Maria Cristina, Steingrimsdottir, Herdis, Elamin, F et al.

    91 cited

28. Correlations of partial and extensive methylation at the p14ARF locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors

    2000 · Carcinogenesis · Zheng, Shichun

    89 cited

29. Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas.

    1996 · PubMed · Huang, Lingyi, Goodrow, Tamra, Zhang, S Y et al.

    86 cited

30. Comparison of mammosphere formation from breast cancer cell lines and primary breast tumors.

    2014 · PubMed · Wang, Rong, Lv, Qing, Meng, Wentong et al.

    84 cited