Most-cited papers on clinical characterization targeting safety target

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

   2009 · Proceedings of the National Academy of Sciences · Chan, Keith Syson, Espinosa, Íñigo, Chao, Mark P. et al.

   678 cited

2. Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

   2014 · Cancer · Bastien, Jayson, McNeill, Katharine, Fine, Howard A.

   136 cited

3. Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation: clinical and genetic characterization and target for therapy

   2014 · Brain · Berge, Laura van, Hamilton, Eline M., Linnankivi, Tarja et al.

   105 cited

4. Characterization of HLA class I specific antibodies by ELISA using solubilized antigen targets: II. clinical relevance

   2001 · Human Immunology · Zachary, Andrea A., Ratner, Lloyd E., Graziani, Julie A. et al.

   64 cited

5. Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells

   2017 · Cancer Research · Sukumar, Selvakumar, Wilson, Douglas C., Yu, Ying et al.

   63 cited

6. Development of a dual target-PCR for detection and characterization of measles virus in clinical specimens

   1996 · Molecular and Cellular Probes · Jin, Li, Richards, Alexsia, Brown, David

   60 cited

7. Enhanced skin targeting of retinoic acid spanlastics:<i>in vitro</i>characterization and clinical evaluation in acne patients

   2018 · Journal of Liposome Research · Shamma, Rehab Nabil, Sayed, Sinar, Sabry, Nirmeen A. et al.

   51 cited

8. Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy

   2009 · Blood · Samarasinghe, Sujith, Mancao, Christoph, Pulé, Martin et al.

   50 cited

9. Phenotypic Characterization of Circulating Lung Cancer Cells for Clinically Actionable Targets

   2019 · Cancers · Kulasinghe, Arutha, Kapeleris, Joanna, Cooper, Carolina et al.

   46 cited

10. Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis

    2011 · Journal of Medical Microbiology · Kommedal, Øyvind, Lekang, Katrine, Langeland, Nina et al.

    42 cited

11. Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical Applications

    2019 · Cancers · Reyes-Garau, Diana, Ribeiro, Marcelo Lima, Roué, Gaël

    41 cited

12. Characterization of transcriptome profile and clinical features of a novel immunotherapy target CD204 in diffuse glioma

    2019 · Cancer Medicine · Yuan, Yongliang, Zhao, Qitai, Zhao, Songfeng et al.

    37 cited

13. Clinical Candidate VT-1161's Antiparasitic Effect<i>In Vitro</i>, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

    2015 · Antimicrobial Agents and Chemotherapy · Hoekstra, William J., Hargrove, Tatiana Y., Wawrzak, Z. et al.

    37 cited

14. Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates

    2022 · iScience · Nordstrom, Hayley R., Evans, Daniel R., Finney, Amanda et al.

    36 cited

15. Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target

    2020 · CNS Neuroscience & Therapeutics · Xu, Hao, Chai, Songshan, Wang, Yihao et al.

    27 cited

16. Lacrimal gland ductal carcinomas: Clinical, Morphological and Genetic characterization and implications for targeted treatment

    2016 · Acta Ophthalmologica · Andreasen, Simon, Grauslund, Morten, Heegaard, Steffen

    26 cited

17. Clinical and metabolic characterization of obese subjects without non-alcoholic fatty liver: A targeted metabolomics approach

    2018 · Diabetes & Metabolism · Feldman, Alexandra, Eder, Sebastian K., Felder, Thomas K. et al.

    24 cited

18. Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy

    2011 · Neuro-Oncology · Guan, Su, Shen, Rulong, LaFortune, Tiffany A. et al.

    23 cited

19. Microdosimetric characterization of a clinical proton therapy beam: comparison between simulated lineal energy distributions in spherical water targets and experimental measurements with a silicon detector

    2021 · Physics in Medicine and Biology · Parisi, Alessio, Olko, P., Swakoń, Jan et al.

    22 cited

20. Extensive Histopathological Characterization of Inflamed Bowel in the Dextran Sulfate Sodium Mouse Model with Emphasis on Clinically Relevant Biomarkers and Targets for Drug Development

    2021 · International Journal of Molecular Sciences · Bonfiglio, Rita, Galli, Filippo, Varani, Michela et al.

    21 cited

21. Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates <i>CXCR4</i> mRNA Expression Levels to Potential Clinical Targets

    2022 · Clinical Cancer Research · Kocher, Florian, Puccini, Alberto, Untergasser, Gerold et al.

    19 cited

22. An Overview on Molecular Characterization of Thymic Tumors: Old and New Targets for Clinical Advances

    2021 · Pharmaceuticals · Tateo, Valentina, Manuzzi, Lisa, Parisi, Claudia et al.

    19 cited

23. The pre-clinical characterization of an alpha-emitting sigma-2 receptor targeted radiotherapeutic

    2015 · Nuclear Medicine and Biology · Makvandi, Mehran, Lieberman, Brian P., LeGeyt, B C. et al.

    19 cited

24. Nonclinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1

    2024 · American Journal of Transplantation · Abend, Johanna R., Sathe, Atul, Wrobel, Matthias B. et al.

    17 cited

25. Synthesis, Photo-Characterizations, and Pre-Clinical Studies on Advanced Cellular and Animal Models of Zinc(II) and Platinum(II) Sulfonyl-Substituted Phthalocyanines for Enhanced Vascular-Targeted Photodynamic Therapy

    2024 · ACS Applied Materials & Interfaces · Repetowski, Paweł, Warszyńska, Marta, Kostecka, Anna et al.

    16 cited

26. ClinSeK: a targeted variant characterization framework for clinical sequencing

    2015 · Genome Medicine · Zhou, Wanding, Zhao, Hao, Chong, Zechen et al.

    15 cited

27. Preclinical characterization and phase I clinical trial of CT053PTSA targets MET, AXL, and VEGFR2 in patients with advanced solid tumors

    2022 · Frontiers in Immunology · Ma, Yuxiang, Liu, Furong, Zhang, Yang et al.

    14 cited

28. Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute Leukemia

    2022 · Frontiers in Molecular Biosciences · Vicente‐Garcés, Clara, Esperanza‐Cebollada, Elena, Montesdeoca, Sara et al.

    13 cited

29. Clinical Characterization of Targetable Mutations (BRAF V600E and KRAS G12C) in Advanced Colorectal Cancer—A Nation-Wide Study

    2023 · International Journal of Molecular Sciences · Potocki, Paweł, Wójcik, Piotr, Chmura, Łukasz et al.

    13 cited

30. Nano-vesicular systems for melanocytes targeting and melasma treatment: In-vitro characterization, ex-vivo skin retention, and preliminary clinical appraisal

    2024 · International Journal of Pharmaceutics · Hatem, Shymaa, Kamel, Amany O., Elkheshen, Seham A. et al.

    13 cited