Most-cited papers on clinical therapy patient predictions synergistic

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

   1988 · PubMed · Bellamy, Nicholas, Buchanan, W. Watson, Goldsmith, Charles H. et al.

   7,827 cited

2. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

   1997 · Journal of Clinical Oncology · Burris, Howard A., Moore, Malcolm J., Andersen, John Sahl et al.

   5,871 cited

3. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline

   2018 · Journal of Clinical Oncology · Brahmer, Julie R., Lacchetti, Christina, Schneider, Bryan J. et al.

   3,654 cited

4. The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

   2005 · Arthritis & Rheumatism · Breedveld, Ferdinand C., Weisman, Michael H., Kavanaugh, Arthur F. et al.

   1,781 cited

5. Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction

   2003 · Circulation · Sweeney, Michael O., Hellkamp, Anne S., Ellenbogen, Kenneth A. et al.

   1,756 cited

6. 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention, 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease, 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction, 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes, and 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery

   2016 · Circulation · Levine, Glenn N., Bates, Eric, Bittl, John A. et al.

   1,324 cited

7. Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

   2020 · JAMA · Li, Ling, Zhang, Wei, Hu, Yu et al.

   1,311 cited

8. Clinical and echocardiographic disease in patients starting end-stage renal disease therapy

   1995 · Kidney International · Foley, Robert N., Parfrey, Patrick S., Harnett, John D. et al.

   1,294 cited

9. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

   2004 · Arthritis & Rheumatism · Keystone, Edward, Kavanaugh, Arthur F., Sharp, John T. et al.

   1,169 cited

10. American Society of Clinical Oncology Provisional Clinical Opinion: Testing for <i>KRAS</i> Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

    2009 · Journal of Clinical Oncology · Allegra, Carmen J., Jessup, J. Milburn, Somerfield, Mark R. et al.

    1,157 cited

11. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials

    2017 · The Lancet · Costa, Francesco, Klaveren, David van, James, Stefan et al.

    1,133 cited

12. long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay

    2002 · Journal of the American College of Cardiology · Auricchio, Angelo, Stellbrink, Christoph, Sack, Stefan et al.

    1,026 cited

13. Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/ <i>neu</i> –Positive Metastatic Breast Cancer

    2008 · Journal of Clinical Oncology · Musolino, Antonino, Naldi, Nadia, Bortesi, Beatrice et al.

    953 cited

14. Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study

    1999 · The Lancet · Ledergerber, Bruno, Egger, Matthias, Opravil, Milos et al.

    933 cited

15. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

    2009 · European Respiratory Journal · Brunelli, Alessandro, Charloux, Anne, Bolliger, Chris T. et al.

    919 cited

16. Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

    2018 · Cancer Discovery · Santomasso, Bianca, Park, Jae H., Salloum, Darin et al.

    910 cited

17. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study

    2000 · The Lancet · Greub, Gilbert, Ledergerber, B, Battegay, Manuel et al.

    902 cited

18. Abbreviated Course of Radiation Therapy in Older Patients With Glioblastoma Multiforme: A Prospective Randomized Clinical Trial

    2004 · Journal of Clinical Oncology · Roa, Wilson, Brasher, Penny, Bauman, Glenn et al.

    887 cited

19. Stereotactic High Dose Fraction Radiation Therapy of Extracranial Tumors Using An Accelerator: Clinical experience of the first thirty-one patients

    1995 · Acta Oncologica · Blomgren, Henric, Lax, Ingmar, Näslund, Ingemar et al.

    841 cited

20. Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes

    2017 · Cell stem cell · Coombs, Catherine C., Zehir, Ahmet, Devlin, Sean M. et al.

    838 cited

21. Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan

    2003 · The Annals of Thoracic Surgery · Kondo, Kazuya, Monden, Yasumasa

    798 cited

22. Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer

    2018 · JAMA Oncology · Emens, Leisha A., Cruz, Cristina, Eder, Joseph P. et al.

    785 cited

23. Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials

    2005 · The Journal of Trauma: Injury, Infection, and Critical Care · Boffard, Kenneth D, Riou, Bruno, Warren, Brian et al.

    783 cited

24. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

    2014 · The Lancet · MacLaren, Robert E., Groppe, Markus, Barnard, Alun R. et al.

    775 cited

25. 6-Month Androgen Suppression Plus Radiation Therapy vs Radiation Therapy Alone for Patients With Clinically Localized Prostate Cancer

    2004 · JAMA · D’Amico, Anthony V., Manola, Judith, Loffredo, Marian et al.

    769 cited

26. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”

    2020 · The Journal of Steroid Biochemistry and Molecular Biology · Castillo, Marta Entrenas, Costa, Luis Manuel Entrenas, Barrios, José Manuel Vaquero et al.

    760 cited

27. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis.

    2003 · PubMed · Linkins, Lori‐Ann, Choi, P., Douketis, James D.

    760 cited

28. Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38

    2008 · Circulation · Wiviott, Stephen D., Braunwald, Eugene, Angiolillo, Dominick J. et al.

    757 cited

29. Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

    1987 · New England Journal of Medicine · Group*, The Veterans Administration Systemic Sepsis Cooperative Study

    708 cited

30. Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group.

    1997 · Journal of Clinical Oncology · Glaspy, John A., Bukowski, Ronald, Steinberg, Douglas et al.

    705 cited