Most-cited papers on dose trials doses superior variations

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

   1998 · The Lancet · Hansson, Lennart, Zanchetti, Alberto, Carruthers, S. George et al.

   5,773 cited

2. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

   2017 · The Lancet · El-Khoueiry, Anthony B., Sangro, Bruno, Yau, Thomas et al.

   4,287 cited

3. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

   2001 · Archives of Ophthalmology · Group, Age-Related Eye Disease Study Research

   3,240 cited

4. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

   2014 · The Lancet · Lee, Daniel W, Kochenderfer, James N., Stetler‐Stevenson, Maryalice et al.

   2,928 cited

5. A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women

   2005 · New England Journal of Medicine · Ridker, Paul M., Cook, Nancy R., Lee, I‐Min et al.

   1,950 cited

6. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

   2014 · The Lancet · Robert, Caroline, Ribas, Antoni, Wolchok, Jedd D. et al.

   1,758 cited

7. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial

   2004 · The Lancet · Verweij, Jaap, Casali, Paolo G., Zalcberg, John et al.

   1,667 cited

8. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial

   1999 · The Lancet · Guay, Laura, Musoke, Philippa, Fleming, Thomas R. et al.

   1,647 cited

9. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial

   2000 · The Lancet · Ronco, Claudio, Bellomo, Rinaldo, Homel, Peter et al.

   1,587 cited

10. Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741

    2003 · Journal of Clinical Oncology · Citron, Marc L., Berry, Donald A., Cirrincione, Constance et al.

    1,560 cited

11. High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention After Myocardial Infarction<SUBTITLE>The IDEAL Study: A Randomized Controlled Trial</SUBTITLE>

    2005 · JAMA · Pedersen, Terje R.

    1,551 cited

12. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

    2015 · The Lancet

    1,472 cited

13. Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

    2020 · The Lancet · Zhu, Fengcai, Li, Yu-Hua, Guan, Xu-Hua et al.

    1,452 cited

14. A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

    1987 · New England Journal of Medicine · Bone, Roger C., Fisher, Charles J., Clemmer, Terry P. et al.

    1,450 cited

15. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR**STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)

    2003 · The American Journal of Cardiology · Jones, Peter H., Davidson, Michael H., Stein, Evan A. et al.

    1,399 cited

16. INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation Therapy

    2002 · Journal of Clinical Oncology · Minsky, Bruce D.

    1,351 cited

17. Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial

    2002 · International Journal of Radiation Oncology*Biology*Physics · Pollack, Alan, Zagars, Gunar K., Starkschall, George et al.

    1,337 cited

18. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial

    2016 · The Lancet Oncology · Dearnaley, David P., Syndikus, Isabel, Mossop, Helen et al.

    1,309 cited

19. Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer

    2007 · International Journal of Radiation Oncology*Biology*Physics · Kuban, Deborah A., Tucker, Susan L., Dong, Lei et al.

    1,245 cited

20. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials

    2003 · BMJ · Law, Michael, Wald, N J, Morris, J K et al.

    1,225 cited

21. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

    2021 · The Lancet · Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A. et al.

    1,205 cited

22. Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

    2012 · Journal of Clinical Oncology · Kantarjian, Hagop M., Thomas, Xavier, Dmoszyńska, Anna et al.

    1,169 cited

23. A Randomized Trial of Induction Chemotherapy plus High-Dose Radiation versus Radiation Alone in Stage III Non-Small-Cell Lung Cancer

    1990 · New England Journal of Medicine · Dillman, Robert O., Seagren, Stephen L., Propert, Kathleen J. et al.

    1,157 cited

24. A Controlled Trial of High-Dose Intravenous Immune Globulin Infusions as Treatment for Dermatomyositis

    1993 · New England Journal of Medicine · Dalakas, Marinos C., Illa, Isabel, Dambrosia, James M. et al.

    1,134 cited

25. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial

    2002 · The Lancet · Schmitz, Norbert, Pfistner, Beate, Sextro, M. et al.

    1,124 cited

26. Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial

    1996 · The Lancet

    1,097 cited

27. Phase III Trial of Standard-Dose Intravenous Cisplatin Plus Paclitaxel Versus Moderately High-Dose Carboplatin Followed by Intravenous Paclitaxel and Intraperitoneal Cisplatin in Small-Volume Stage III Ovarian Carcinoma: An Intergroup Study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group

    2001 · Journal of Clinical Oncology · Markman, Maurie, Bundy, Brian N., Alberts, David S. et al.

    1,087 cited

28. Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033

    2008 · Journal of Clinical Oncology · Blanke, Charles D., Rankin, Cathryn, Demetri, George D. et al.

    1,075 cited

29. Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

    2013 · Journal of Clinical Oncology · Gilbert, Mark R., Wang, Meihua, Aldape, Kenneth et al.

    1,072 cited