Most-cited papers on dysfunction endothelial signaling vascular generation

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

   2008 · Cell and Tissue Research · Bakker, Wineke, Eringa, Etto C., Sipkema, Pieter et al.

   327 cited

2. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis

   2010 · Critical Care · Shapiro, Nathan I., Schüetz, Philipp, Yano, Kiichiro et al.

   266 cited

3. Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

   2000 · Circulation Research · Oelze, Matthias, Mollnau, Hanke, Hoffmann, Nina et al.

   257 cited

4. Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

   2015 · International Journal of Nanomedicine · Guo, Caixia, Xia, Yinye, Niu, Piye et al.

   242 cited

5. Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

   2014 · International Journal of Nanomedicine · Duan, Yu, Yongbo, Yu, Yang et al.

   179 cited

6. Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway

   2017 · BioMed Research International · Cai, Wei, Duan, Xi-Mei, Liu, Ying et al.

   175 cited

7. Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction

   2005 · American Journal of Physiology-Heart and Circulatory Physiology · Varma, Shubha, Lal, Brajesh K., Zheng, Ruifang et al.

   142 cited

8. Angiotensin II Regulates Vascular and Endothelial Dysfunction: Recent Topics of Angiotensin II Type-1 Receptor Signaling in the Vasculature

   2005 · Current Vascular Pharmacology · Nakashima, H., Suzuki, Hiroyuki, Ohtsu, Haruhiko et al.

   138 cited

9. Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

   2018 · Molecules · Hu, Shaonan, Wu, Yali, Zhao, Bo et al.

   136 cited

10. Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2/HO-1 signaling pathway

    2023 · Phytomedicine · Sha, Wenjun, Zhao, Bei, Wei, Huizhen et al.

    136 cited

11. Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction

    2012 · Medicinal Research Reviews · Rigor, Robert R., Shen, Qiang, Pivetti, Christopher D. et al.

    127 cited

12. Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia

    1997 · Experimental Physiology · Sobrevía, Luis, Mann, Giovanni E.

    124 cited

13. Hydrogen Sulfide Attenuated Tumor Necrosis Factor-α-Induced Inflammatory Signaling and Dysfunction in Vascular Endothelial Cells

    2011 · PLoS ONE · Pan, Li‐Long, Liu, Xinhua, Gong, Qihai et al.

    120 cited

14. Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a–JNK Signaling

    2016 · Arteriosclerosis Thrombosis and Vascular Biology · Bretón‐Romero, Rosa, Feng, Bihua, Holbrook, Monika et al.

    118 cited

15. Cyanidin-3-<i>O</i>-glucoside Protection against TNF-α-Induced Endothelial Dysfunction: Involvement of Nuclear Factor-κB Signaling

    2010 · Journal of Agricultural and Food Chemistry · Speciale, Antonio, Canali, Raffaella, Chirafisi, Joselita et al.

    116 cited

16. Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

    2007 · British Journal of Pharmacology · Chung, A.W., Yeung, Karen Au, Côrtes, Steyner F. et al.

    113 cited

17. Oxidative stress, redox signalling and endothelial dysfunction in ageing‐related neurodegenerative diseases: a role of <scp>NADPH</scp> oxidase 2

    2014 · British Journal of Clinical Pharmacology · Cahill‐Smith, Sarah, Li, Jian‐Mei

    105 cited

18. Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

    2017 · Inflammation · Deng, Xian, Huang, Wei, Peng, Juan et al.

    98 cited

19. Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia

    2016 · Scientific Reports · McCarthy, Cathal, Kenny, Louise C.

    97 cited

20. A Pivotal Role of Endothelial-Specific NF-κB Signaling in the Pathogenesis of Septic Shock and Septic Vascular Dysfunction

    2009 · The Journal of Immunology · Ding, Jianqiang, Song, Dongmei, Ye, Xiaobing et al.

    95 cited

21. Endothelial Cell Signaling and Endothelial Dysfunction

    1995 · American Journal of Hypertension · Flavahan, Nicholas A.

    94 cited

22. Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis

    2016 · Diabetes and Vascular Disease Research · Dong, Yunzhou, Fernandes, Conrad J., Liu, Yanjun et al.

    93 cited

23. Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling

    2017 · Cellular Physiology and Biochemistry · Hou, Biyu, Qiang, Guifen, Zhao, Yuerong et al.

    91 cited

24. Inflammation dysregulates Notch signaling in endothelial cells: Implication of Notch2 and Notch4 to endothelial dysfunction

    2010 · Biochemical Pharmacology · Quillard, Thibaut, Devallière, Julie, Coupel, Stéphanie et al.

    90 cited

25. Ca2+ signaling mechanisms of vascular endothelial cells and their role in oxidant-induced endothelial cell dysfunction

    1992 · American Journal of Physiology-Heart and Circulatory Physiology · Schilling, William P., Elliott, Stephen N.

    87 cited

26. Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway

    2018 · Life Sciences · Leng, Bin, Tang, Futian, Lü, Meili et al.

    84 cited

27. Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway

    2015 · International Immunopharmacology · Chen, Hongguang, Xie, Keliang, Han, Huan-zhi et al.

    83 cited

28. RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction

    2011 · Arteriosclerosis Thrombosis and Vascular Biology · Venkatesh, Deepak, Fredette, Natalie C., Rostama, Bahman et al.

    80 cited

29. Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways

    2014 · Biochemical Pharmacology · Tang, Yubo, Jacobi, Angela, Vater, Corina et al.

    80 cited

30. Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes

    2010 · International Journal of Diabetes Mellitus · Popov, Doina

    79 cited