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Most-cited papers on human clinical translatability relevance segments

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

Stem cells in human neurodegenerative disorders — time for clinical translation?
2010 · Journal of Clinical Investigation · Lindvall, Olle, Kokaia, Zaal
610 cited
Epigenetics and human disease: translating basic biology into clinical applications
2006 · Canadian Medical Association Journal · Rodenhiser, D.
472 cited
Dose translation between laboratory animals and human in preclinical and clinical phases of drug development
2018 · Drug Development Research · Nair, Anroop B., Morsy, Mohamed A., Jacob, Shery
444 cited
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
2018 · Pharmacological Reviews · Sieghart, Werner, Savić, Miroslav M.
215 cited
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation
2024 · Signal Transduction and Targeted Therapy · Ma, Ziqi, Zuo, Tao, Frey, Norbert et al.
174 cited
Translating dosages from animal models to human clinical trials—revisiting body surface area scaling
2015 · The FASEB Journal · Blanchard, Otis L., Smoliga, James M.
171 cited
Sympathetic nerve activity and neurotransmitter release in humans: translation from pathophysiology into clinical practice
2003 · Acta Physiologica Scandinavica · Esler, Murray, Lambert, Gavin, Rocca, Hans‐Peter Brunner‐La et al.
166 cited
Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation
2019 · International Journal of Molecular Sciences · Sagaradze, Georgy, Grigorieva, Olga, Nimiritsky, Peter et al.
160 cited
Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation
2012 · Regenerative Medicine · Gimble, Jeffrey M., Bunnell, Bruce A., Guilak, Farshid
158 cited
Hurdles to clinical translation of human induced pluripotent stem cells
2015 · Journal of Clinical Investigation · Neofytou, Evgenios, O’Brien, Connor, Couture, Larry A. et al.
158 cited
Clinical Translation and First In-Human Use of [<sup>44</sup>Sc]Sc-PSMA-617 for PET Imaging of Metastasized Castrate-Resistant Prostate Cancer
2017 · Theranostics · Eppard, Elisabeth, Fuente, Ana de la, Benešová, Martina et al.
140 cited
Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice
2016 · Journal of Proteomics · Azkargorta, Mikel, Soria, Javier Millán, Acera, Arantxa et al.
103 cited
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
2022 · Cell stem cell · Giacomelli, Elisa, Vahsen, Björn F., Calder, Elizabeth L. et al.
99 cited
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
2022 · EBioMedicine · Zhu, Yi, Prata, Larissa, Gerdes, Erin O. Wissler et al.
87 cited
Anti-Human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
2020 · Biomolecules · Bridoux, Jessica, Broos, Katrijn, Lecocq, Quentin et al.
73 cited
Gene therapy for human osteoarthritis: principles and clinical translation
2015 · Expert Opinion on Biological Therapy · Madry, Henning, Cucchiarini, Magali
64 cited
Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures
2018 · Scientific Reports · Ashrafi, Mohammed, Frazer, Lilyann Novak, Bates, Matthew et al.
64 cited
Robust Revascularization in Models of Limb Ischemia Using a Clinically Translatable Human Stem Cell-Derived Endothelial Cell Product
2018 · Molecular Therapy · MacAskill, Mark G., Saif, Jaimy, Condie, Alison et al.
62 cited
Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation
2020 · Stem Cells International · Rady, Dina, Abbass, Marwa M. S., El‐Rashidy, Aiah A. et al.
61 cited
Mimicking of Human Body Electrical Characteristic for Easier Translation of Plasma Biomedical Studies to Clinical Applications
2019 · IEEE Transactions on Radiation and Plasma Medical Sciences · Stancampiano, Augusto, Chung, Thai-Hoa, Dozias, Sébastien et al.
58 cited
3D-bioprinted human tissue and the path toward clinical translation
2022 · Science Translational Medicine · Bliley, Jacqueline M., Shiwarski, Daniel J., Feinberg, Adam W.
57 cited
Microelectrode recordings in human epilepsy: a case for clinical translation
2020 · Brain Communications · Chari, Ajai, Thornton, Rachel C, Tisdall, Martin et al.
56 cited
Clinical translation of human neural stem cells
2013 · Stem Cell Research & Therapy · Tsukamoto, Ann, Uchida, Nobuko, Capela, Alexandra et al.
53 cited
Dosimetry Prediction for Clinical Translation of 64Cu-Pembrolizumab ImmunoPET Targeting Human PD-1 Expression
2018 · Scientific Reports · Natarajan, Arutselvan, Patel, Chirag B., Habte, Frezghi et al.
52 cited
Cancer vaccines: translation from mice to human clinical trials
2018 · Current Opinion in Immunology · Maeng, Hoyoung, Terabe, Masaki, Berzofsky, Jay A.
51 cited
Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
2015 · EBioMedicine · Mendell, Jeanne, Freeman, Daniel J., Feng, Wenqin et al.
49 cited
Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation
2020 · Cancers · Soubéran, Aurélie, Tchoghandjian, Aurélie
46 cited
Inhaled efficacious dose translation from rodent to human: A retrospective analysis of clinical standards for respiratory diseases
2017 · Pharmacology & Therapeutics · Phillips, Jonathan E.
45 cited
Cancer vaccine strategies: translation from mice to human clinical trials
2017 · Cancer Immunology Immunotherapy · Berzofsky, Jay A., Terabe, Masaki, Trepel, Jane B. et al.
43 cited