Most-cited papers on kinetics binding rates compare ambient

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

   1994 · Proceedings of the National Academy of Sciences · Matsui, Kouhei, Boniface, J. Jay, Steffner, P et al.

   421 cited

2. Interpreting Complex Binding Kinetics from Optical Biosensors: A Comparison of Analysis by Linearization, the Integrated Rate Equation, and Numerical Integration

   1995 · Analytical Biochemistry · Morton, Thomas A., Myszka, David G., Chaiken, Irwin

   332 cited

3. Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

   1986 · Proceedings of the National Academy of Sciences · Saluz, H. P., Jiricny, Josef, Jost, J P

   223 cited

4. Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site.

   1985 · Molecular Pharmacology · Rhodes, David G., Sarmiento, J. George, Herbette, Leo G.

   152 cited

5. Combined Affinity and Rate Constant Distributions of Ligand Populations from Experimental Surface Binding Kinetics and Equilibria

   2003 · Biophysical Journal · Švitel, Juraj, Balbo, Andrea, Mariuzza, Roy A. et al.

   128 cited

6. Yeast TATA binding protein interaction with DNA: fluorescence determination of oligomeric state, equilibrium binding, on-rate, and dissociation kinetics

   1995 · Biochemistry · Perez-Howard, Gina M., Weil, P. Anthony, Beechem, Joseph

   122 cited

7. SEEKR: Simulation Enabled Estimation of Kinetic Rates, A Computational Tool to Estimate Molecular Kinetics and Its Application to Trypsin–Benzamidine Binding

   2017 · The Journal of Physical Chemistry B · Votapka, Lane, Jagger, Benjamin R., Heyneman, Alexandra L. et al.

   100 cited

8. Mechanical Measurement of Single-molecule Binding Rates: Kinetics of DNA Helix-destabilization by T4 Gene 32 Protein

   2003 · Journal of Molecular Biology · Pant, Kiran, Karpel, Richard L., Rouzina, Ioulia et al.

   97 cited

9. The binding of antigen by immobilized antibody: Influence of a variable adsorption rate coefficient on external diffusion limited kinetics

   1992 · Journal of Colloid and Interface Science · Sadana, Ajit, Sii, David

   95 cited

10. Kinetics of deoxyhemoglobin subunit dissociation determined by haptoglobin binding: estimation of the equilibrium constant from forward and reverse rates

    1976 · Biochemistry · Ip, S H, Johnson, Michael L., Ackers, Gary K.

    91 cited

11. Transient Kinetics and Rate-Limiting Steps for the Processive Cellobiohydrolase Cel7A: Effects of Substrate Structure and Carbohydrate Binding Domain

    2013 · Biochemistry · Cruys‐Bagger, Nicolaj, Tatsumi, Hirosuke, Ren, Guilin et al.

    91 cited

12. Kinetics of binding of [3H]acetylcholine to Torpedo postsynaptic membranes: association and dissociation rate constants by rapid mixing and ultrafiltration

    1980 · Biochemistry · Boyd, Norman D., Cohen, Jonathan B.

    67 cited

13. Kinetics of H+ ion binding by the P+QA-state of bacterial photosynthetic reaction centers: rate limitation within the protein

    1997 · Biophysical Journal · Maróti, Péter, Wraight, Colin A.

    67 cited

14. Kinetics of binding and hydrolysis of a series of nucleoside triphosphates by actomyosin-S1. Relationship between solution rate constants and properties of muscle fibers

    1993 · Journal of Biological Chemistry · White, Howard D., Belknap, Betty, Jiang, Wei

    60 cited

15. Platelet Transport Rates and Binding Kinetics at High Shear over a Thrombus

    2013 · Biophysical Journal · Bark, David, Ku, David N.

    53 cited

16. Kinetics of protein binding determine rates of uptake of drugs by brain

    1986 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · Robinson, Philip J., Рапопорт, С. И.

    51 cited

17. Binding Kinetics of Antigen by Immobilized Antibody or of Antibody by Immobilized Antigen: Influence of Lateral Interactions and Variable Rate Coefficients

    1993 · Biotechnology Progress · Sadana, Ajit, Madugula, A.

    45 cited

18. Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels

    2013 · Journal of Biomechanics · Nims, Robert J., Cigáň, A., Albro, Michael B. et al.

    38 cited

19. Competitive binding kinetics in ligand-receptor-competitor systems. Rate parameters for unlabeled ligands for the formyl peptide receptor.

    1985 · Molecular Pharmacology · Sklar, L A, Sayre, J, McNeil, V.M. et al.

    35 cited

20. Antigen‐Antibody Binding Kinetics for Biosensors: The Fractal Dimension and the Binding Rate Coefficient

    1995 · Biotechnology Progress · Sadana, Ajit

    34 cited

21. Inhalation by Design: Novel Tertiary Amine Muscarinic M₃Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

    2011 · Journal of Medicinal Chemistry · Glossop, Paul A., Watson, Christine, Price, David et al.

    33 cited

22. Dissection of the Physiological Interconversion of 5α-DHT and 3α-Diol by Rat 3α-HSD via Transient Kinetics Shows That the Chemical Step Is Rate-Determining:  Effect of Mutating Cofactor and Substrate-Binding Pocket Residues on Catalysis

    2004 · Biochemistry · Heredia, Vladi V., Penning, T.M.

    26 cited

23. Rate constants of agonist binding to muscarinic receptors in rat brain medulla. Evaluation by competition kinetics.

    1985 · Journal of Biological Chemistry · Schreiber, Gabriel, Henis, Yoav I., Sokolovsky, Mordechai

    25 cited

24. Kinetics of Gelsolin Interaction with Phalloidin-Stabilized F-Actin. Rate Constants for Binding and Severing

    1996 · Biochemistry · Kinosian, Henry J., Selden, Lynn A., Estes, James E. et al.

    24 cited

25. Comparison between the unfolding rate and structural fluctuations in native lysozyme—effects of denaturants, ligand binding, and intrachain cross‐linking on hydrogen exchange and unfolding kinetics

    1986 · Biopolymers · Segawa, Shin-ichi, Kume, Katsuya

    16 cited

26. Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter

    2022 · Biochemistry · Wernersson, Sven, Birgersson, Simon, Akke, Mikael

    12 cited

27. Analysis of analyte–receptor binding kinetics for biosensor applications: an overview of the influence of the fractal dimension on the surface on the binding rate coefficient

    1999 · Biotechnology and Applied Biochemistry · Ramakrishnan, Anand, Sadana, Ajit

    9 cited

28. Kinlsq: A Program for Fitting Kinetics Data with Numerically Integrated Rate Equations and Its Application to the Analysis of Slow, Tight-Binding Inhibition Data

    1994 · Analytical Biochemistry · Gutheil, William G., Kettner, Carsten, Bachovchin, William W.

    8 cited

29. An Analysis of Analyte–Receptor Binding Kinetics for Biosensor Applications: Influence of the Fractal Dimension on the Binding Rate Coefficient

    1998 · Journal of Colloid and Interface Science · Sadana, Ajit

    8 cited