Most-cited papers on patient controlled clinical trials randomized

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

   2005 · Arthritis & Rheumatism · Goekoop-Ruiterman, Y P M, Vries‐Bouwstra, Jeska K de, Allaart, Cornelia F et al.

   1,459 cited

2. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

   2004 · Arthritis & Rheumatism · Keystone, Edward, Kavanaugh, Arthur F., Sharp, John T. et al.

   1,169 cited

3. Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

   2006 · Arthritis & Rheumatism · Maini, Ravinder N., Taylor, Peter C., Szechiński, Jacek et al.

   792 cited

4. Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials

   2005 · The Journal of Trauma: Injury, Infection, and Critical Care · Boffard, Kenneth D, Riou, Bruno, Warren, Brian et al.

   783 cited

5. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial

   2015 · Nutrition · Akkasheh, Ghodarz, Kashani-Poor, Zahra, Ebrahimi, Maryam et al.

   749 cited

6. Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

   2008 · Journal of Clinical Psychopharmacology · Baum, Larry, Lam, Christopher Wai Kei, Cheung, Stanley K. K. et al.

   584 cited

7. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients

   1999 · Critical Care Medicine · Brower, Roy G., Shanholtz, Carl, Fessler, H et al.

   577 cited

8. Physical Exercise in Cancer Patients During and After Medical Treatment: A Systematic Review of Randomized and Controlled Clinical Trials

   2005 · Journal of Clinical Oncology · Knols, Ruud H., Aaronson, Neil K., Uebelhart, Daniel et al.

   576 cited

9. Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: Double-blind, randomized controlled trial and open-label extension study

   2006 · Journal of the American Academy of Dermatology · Gordon, Kenneth B., Langley, Richard G., Leonardi, Craig L. et al.

   506 cited

10. Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    2002 · Annals of Internal Medicine · Everdingen, Amalia A. van, Jacobs, Johannes W. G., Reesema, Dirk R. Siewertsz van et al.

    488 cited

11. WellDoc ^™ Mobile Diabetes Management Randomized Controlled Trial: Change in Clinical and Behavioral Outcomes and Patient and Physician Satisfaction

    2008 · Diabetes Technology & Therapeutics · Quinn, Charlene C., Clough, Suzanne Sysko, Minor, James M. et al.

    424 cited

12. Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group

    2006 · Journal of Clinical Oncology · Strasser, Florian, Lüftner, Diana, Possinger, Kurt et al.

    409 cited

13. Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury

    1999 · Critical Care Medicine · Taylor, Stephen J., Fettes, S. B., Jewkes, Claire et al.

    407 cited

14. Clinical trial: lubiprostone in patients with constipation‐associated irritable bowel syndrome – results of two randomized, placebo‐controlled studies

    2008 · Alimentary Pharmacology & Therapeutics · Drossman, Douglas A., Chey, William D., Johanson, John F. et al.

    394 cited

15. Randomized Controlled Clinical Effectiveness Trial of Cognitive Behavior Therapy Compared With Treatment As Usual for Persistent Insomnia in Patients With Cancer

    2008 · Journal of Clinical Oncology · Espie, Colin A., Fleming, Leanne, Cassidy, James T. et al.

    389 cited

16. Patient morbidity and root coverage outcome after subepithelial connective tissue and de‐epithelialized grafts: a comparative randomized‐controlled clinical trial

    2010 · Journal Of Clinical Periodontology · Zucchelli, Giovanni, Mele, M. Fernández Lorenzo de, Stefanini, Martina et al.

    387 cited

17. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy

    2013 · European Spine Journal · Albert, H, Sørensen, Joan Solgaard, Christensen, Berit Schiott et al.

    384 cited

18. Randomized Controlled Clinical Trial of Surgery<i>Versus</i>No Surgery in Patients with Mild Asymptomatic Primary Hyperparathyroidism

    2004 · The Journal of Clinical Endocrinology & Metabolism · Rao, D. Sudhaker, Phillips, Evelyn R., Divine, George et al.

    375 cited

19. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six‐month, multicenter, randomized, double‐blind, controlled, phase IV trial

    2007 · Arthritis & Rheumatism · Braun, Jürgen, Kastner, Philipp, Flaxenberg, P. et al.

    345 cited

20. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study

    2019 · Journal of Psychiatric Research · Greden, John F., Parikh, Sagar V., Rothschild, Anthony J. et al.

    335 cited

21. Safety and efficacy of a <scp>CXCR</scp>2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo‐controlled clinical trial

    2012 · Clinical & Experimental Allergy · Nair, Parameswaran, Gaga, Mina, Ζervas, Εleftherios et al.

    330 cited

22. Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial

    2006 · Human Reproduction · Andersen, Anders Nyboe, Devroey, Paul, Arce, Joan‐Carles

    323 cited

23. RETRACTED: Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled trial

    2016 · Clinical Nutrition · Kouchaki, Ebrahim, Tamtaji, Omid Reza, Salami, Mahmoud et al.

    311 cited

24. Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial

    2008 · American Journal of Clinical Nutrition · Gisondi, Paolo, Giglio, Micol Del, Francesco, Vincenzo Di et al.

    305 cited

25. Influence of Combined Intravenous and Topical Antibiotic Prophylaxis on the Incidence of Infections, Organ Dysfunctions, and Mortality in Critically Ill Surgical Patients: A Prospective, Stratified, Randomized, Double-Blind, Placebo-controlled Clinical Trial

    2002 · American Journal of Respiratory and Critical Care Medicine · Krueger, Wolfgang A., Lenhart, Franz-Peter, Neeser, G. et al.

    301 cited

26. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*

    2003 · Critical Care Medicine · Garrel, Dominique R., Patenaude, Julie, Nedelec, Bernadette et al.

    295 cited

27. A Randomized Clinical Trial of a Brief Hypnosis Intervention to Control Side Effects in Breast Surgery Patients

    2007 · JNCI Journal of the National Cancer Institute · Montgomery, Guy H., Bovbjerg, Dana H., Schnur, Julie B. et al.

    292 cited

28. Investigation of Clinical Effects of High- and Low-Resistance Training for Patients With Knee Osteoarthritis: A Randomized Controlled Trial

    2008 · Physical Therapy · Jan, Mei‐Hwa, Lin, Jiu‐Jenq, Liau, Jiann‐Jong et al.

    292 cited

29. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials

    2014 · Biological Psychiatry · Herring, W. Joseph, Connor, Kathryn M., Ivgy-May, Neely et al.

    289 cited

30. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial

    2004 · Phytomedicine · Herrera-Arellano, Armando, Flores-Romero, S, Chávez-Soto, Marco Antonio et al.

    284 cited