Most-cited papers on patient treatment clinical follow progression

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II‐defined cohort of patients with progressive multiple sclerosis: results of a 24‐month double‐blind placebo‐controlled clinical trial and 5 years of follow‐up treatment

   2006 · European Journal of Neurology · Warren, Kenneth G., Catz, Ingrid, Ferenczi, L. Z. et al.

   147 cited

2. The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

   2005 · Arthritis & Rheumatism · Breedveld, Ferdinand C., Weisman, Michael H., Kavanaugh, Arthur F. et al.

   1,781 cited

3. Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline

   2008 · The Journal of Clinical Endocrinology & Metabolism · Funder, John W., Carey, Robert M., Fardella, Carlos et al.

   1,548 cited

4. A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

   1989 · New England Journal of Medicine · Fisher, B., Costantino, Joseph, Redmond, Carol et al.

   1,479 cited

5. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

   2005 · Arthritis & Rheumatism · Goekoop-Ruiterman, Y P M, Vries‐Bouwstra, Jeska K de, Allaart, Cornelia F et al.

   1,459 cited

6. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update

   2019 · Journal of Clinical Oncology · Key, Nigel S., Khorana, Alok A., Kuderer, Nicole M. et al.

   1,451 cited

7. Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

   1997 · Blood · Shen, Zhixiang, Chen, Guoqiang, Ni, Jian-Hua et al.

   1,430 cited

8. ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer

   2021 · Annals of Oncology · Gennari, Alessandra, André, Fabrice, Barrios, Carlos H. et al.

   1,323 cited

9. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

   2004 · Arthritis & Rheumatism · Keystone, Edward, Kavanaugh, Arthur F., Sharp, John T. et al.

   1,169 cited

10. Evidence-based treatment and practice: New opportunities to bridge clinical research and practice, enhance the knowledge base, and improve patient care.

    2008 · American Psychologist · Kazdin, Alan E.

    1,122 cited

11. Clinical features and treatment of COVID‐19 patients in northeast Chongqing

    2020 · Journal of Medical Virology · Wan, Suxin, Xiang, Yi, Fang, Wei et al.

    1,042 cited

12. Analysis and Interpretation of Treatment Effects in Subgroups of Patients in Randomized Clinical Trials

    1991 · JAMA · Yusuf, Salim

    973 cited

13. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer

    2007 · Journal of Clinical Oncology · Lyman, Gary H., Khorana, Alok A., Falanga, Anna et al.

    952 cited

14. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome

    2016 · Journal of Neuroinflammation · (NEMOS), in cooperation with the Neuromyelitis Optica Study Group, Jarius, Sven, Ruprecht, Klemens et al.

    889 cited

15. Helping patients follow prescribed treatment: clinical applications.

    2002 · PubMed · Haynes, R. Brian, McDonald, Heather, Garg, Amit X.

    857 cited

16. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”

    2020 · The Journal of Steroid Biochemistry and Molecular Biology · Castillo, Marta Entrenas, Costa, Luis Manuel Entrenas, Barrios, José Manuel Vaquero et al.

    760 cited

17. The MacCAT-T: a clinical tool to assess patients' capacities to make treatment decisions

    1997 · Psychiatric Services · Grisso, Thomas, Appelbaum, Paul S., Hill‐Fotouhi, Carolyn

    688 cited

18. National Clinical Guidelines for non-surgical treatment of patients with recent onset low back pain or lumbar radiculopathy

    2017 · European Spine Journal · Stochkendahl, Mette Jensen, Kjær, Per, Hartvigsen, Jan et al.

    682 cited

19. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes

    2006 · Neurology · Kappos, Ludwig, Polman, C. H., Freedman, Mark S. et al.

    677 cited

20. Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years

    2012 · Pediatric Blood & Cancer · Haupt, Riccardo, Minkov, Milen, Astigarraga, Itziar et al.

    676 cited

21. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID‐19

    2020 · Journal of Thrombosis and Haemostasis · Spyropoulos, Alex C., Levy, Jerrold H., Ageno, Walter et al.

    668 cited

22. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

    2009 · Clinical Immunology · Trzonkowski, Piotr, Bieniaszewska, Maria, Juścińska, Jolanta et al.

    661 cited

23. Behavioral Treatment of Depression in Dementia Patients: A Controlled Clinical Trial

    1997 · The Journals of Gerontology Series B · Teri, Linda, Logsdon, R. G., Uomoto, Jay M. et al.

    653 cited

24. Clinical Effectiveness and Cost-Effectiveness of Treatments for Patients With Chronic Pain

    2002 · Clinical Journal of Pain · Turk, Dennis C.

    648 cited

25. 2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer

    2019 · The Lancet Oncology · Farge, Dominique, Frère, Corinne, Connors, Jean M. et al.

    648 cited

26. EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours

    2017 · Annals of Oncology · Rhun, Émilie Le, Weller, Michael, Brandsma, Dieta et al.

    632 cited

27. Clinical picture and treatment of 2212 patients with common variable immunodeficiency

    2014 · Journal of Allergy and Clinical Immunology · Gathmann, Benjamin, Mahlaoui, Nizar, Gérard, Laurence et al.

    629 cited

28. Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study

    2019 · The Lancet · Carrat, Fabrice, Fontaine, Hélène, Dorival, Céline et al.

    622 cited

29. Benign Paragangliomas: Clinical Presentation and Treatment Outcomes in 236 Patients

    2001 · The Journal of Clinical Endocrinology & Metabolism · Erickson, Dana, Kudva, Yogish C., Ebersold, Michael J. et al.

    605 cited