Most-cited papers on patient treatment patients clinical wide

Ranked by citation count via OpenAlex. Citations update on a rolling basis; list regenerates every 24h.

1. Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial

   2019 · Circulation · Damask, Amy, Steg, Philippe Gabríel, Schwartz, Gregory G. et al.

   241 cited

2. The anti‐emetic efficacy of maropitant (Cerenia™) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe

   2007 · Journal of Small Animal Practice · Puente-Redondo, Victor A. de la, Siedek, E. M., Benchaoui, H. A. et al.

   70 cited

3. Effect of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study

   2016 · Heart Rhythm · Chan, Esther W., Lau, Wallis C. Y., Siu, Chung Wah et al.

   52 cited

4. The persistence of golimumab compared to other tumour necrosis factor-α inhibitors in daily clinical practice for the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis: observations from the Slovenian nation-wide longitudinal registry of patients treated with biologic disease-modifying antirheumatic drugs—BioRx.si

   2018 · Clinical Rheumatology · Rheumatologists, on behalf of the Slovenian, Rotar, Žiga, Tomšič, Matija et al.

   18 cited

5. Patient satisfaction with psychotropic drugs: sensitivity to change and relationship to clinical status, quality-of-life, compliance and effectiveness of treatment. Results from a nation-wide 6-month prospective study

   2006 · European Psychiatry · Gasquet, I., Tcherny‐Lessenot, Stéphanie, Lépine, Jean‐Pierre et al.

   17 cited

6. Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study

   2014 · Open Forum Infectious Diseases · Henrich, Timothy J., McLaren, Paul J., Rao, Suhas S.P. et al.

   8 cited

7. Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients

   2014 · Clinical Pharmacology & Therapeutics · Pinto, Navin, Gamazon, Eric R., Antao, Nirav et al.

   7 cited

8. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

   1998 · The Lancet

   20,015 cited

9. Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis

   1996 · New England Journal of Medicine · Mazzaferro, Vincenzo, Regalia, Enrico, Doci, Roberto et al.

   7,098 cited

10. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

    1998 · The Lancet · Hansson, Lennart, Zanchetti, Alberto, Carruthers, S. George et al.

    5,773 cited

11. Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

    2002 · JAMA · Group, The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research

    5,679 cited

12. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

    2012 · The Lancet Oncology · Rosell, Rafael, Carcereny, Enric, Gervais, Radj et al.

    5,514 cited

13. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

    2018 · The Lancet · Kudo, Masatoshi, Finn, Richard S., Qin, Shukui et al.

    5,379 cited

14. Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

    2005 · New England Journal of Medicine · Group, The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research

    5,131 cited

15. Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

    2017 · American Journal of Nephrology · Locatelli, Francesco, Fishbane, Steven, Block, Geoffrey A. et al.

    4,816 cited

16. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper

    2004 · European Respiratory Journal · Celli, Bartolomé R., MacNee, William, Agustí, Àlvar et al.

    4,427 cited

17. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

    2011 · The Lancet Oncology · Zhou, Caicun, Wu, Yi‐Long, Chen, Gongyan et al.

    4,090 cited

18. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

    2020 · Journal of Thrombosis and Haemostasis · Tang, Ning, Bai, Huan, Chen, Xing et al.

    3,736 cited

19. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

    2016 · The Lancet · Rosenberg, Jonathan E., Hoffman‐Censits, Jean, Powles, Tom et al.

    3,699 cited

20. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

    2016 · The Lancet · Bruix, Jordi, Qin, Shukui, Merle, Philippe et al.

    3,641 cited

21. Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients

    2001 · Journal of Clinical Oncology · Stein, John P., Lieskovsky, Gary, Cote, Rick et al.

    3,526 cited

22. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial

    2002 · The Lancet · Llovet, Josep M., Real, María Isabel, Montañá, Xavier et al.

    3,491 cited

23. Treatment of Hypertension in Patients 80 Years of Age or Older

    2008 · New England Journal of Medicine · Beckett, Nigel, Peters, Ruth, Fletcher, Astrid et al.

    3,084 cited

24. Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

    2002 · JAMA · Annane, Djillali

    3,072 cited

25. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

    2013 · The Lancet Neurology · Titulaer, Maarten J., McCracken, Lindsey, Gabilondo, Iñigo et al.

    3,069 cited

26. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension

    1997 · The Lancet · Staessen, Jan A., Fagard, Robert, Thijs, Lutgarde et al.

    3,000 cited

27. The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

    1987 · New England Journal of Medicine · Fischl, Margaret A., Richman, Douglas D., Grieco, Michael H. et al.

    2,986 cited

28. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators

    1995 · JAMA · Connors, Alfred F., Dawson, Neal V., Desbiens, Norman A. et al.

    2,778 cited

29. Effective treatment of severe COVID-19 patients with tocilizumab

    2020 · Proceedings of the National Academy of Sciences · Xu, Xiaoling, Han, Mingfeng, Li, Tiantian et al.

    2,773 cited

30. A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

    1987 · New England Journal of Medicine · Rosenberg, Steven A., Lotze, Michael T., Muul, Linda et al.

    2,763 cited