Recent papers on Developmental Stage Specificity
Sorted by publication year (newest first) via OpenAlex. List regenerates every 24h.
- 2026
2026 · Molecular Biology Reports · Singh, Devender, Sarwalia, Parul, Kumar, Manish et al.
- 2026
Developmental stage-specific disruption of iron allocation by a ZmYSL2 mutation in maize
2026 · Planta · Wang, Yikai, Zhang, Ke, An, Chuang et al.
- 2026
2026 · Milek, Joel Joshua, Koppensteiner, Lukas J., Bernardini, Luca Giuliano et al.
- 2026
2026 · Open MIND · Tripdatabase
- 2026
2026 · Journal of Affective Disorders · Li, Yichen, Li, Peng, Deng, Yanhe
- 2025
2025 · bioRxiv (Cold Spring Harbor Laboratory) · Satarkar, Devi, López‐Idiáquez, David, Sepil, Irem et al.
- 2026
2026 · Environment & Health · Cheng, Jiexia, Tang, Gang, Wang, Ziniu et al.
- 2026
Larval developmental histories shape phenotypes and stage‐specific fitness of a reef fish
2026 · Ecology · Shima, Jeffrey, Swearer, Stephen E.
- 2026
2026 · Molecular Biology Reports · Ganesh, Botta Thandava, Katral, Ashvinkumar, Muthusamy, Vignesh et al.
- 2026
2026 · Esipov, Sergei E., Krivolapov, Yu. А.
- 2026
Protein kinase N2 (PKN2) is essential for embryonic heart development, but the precise timing and cellular requirement in cardiomyocytes are not well understood. In a constitutive cardiomyocyte specific knockout (cKO) of PKN2, we observed partially penetrant early postnatal lethality, nonprogressive systolic dysfunction in survivors, and a distinctive coin pouch ventricular geometry resembling the embryonic shape, linking the phenotype to a developmental origin rather than ongoing pathology. By tracking heart morphogenesis, we found that mutant and control hearts were still grossly indistinguishable at E10.5, defining an unbiased stage for molecular profiling before secondary remodeling. Integrative RNAseq, proteomics, and phosphoproteomics at E10.5 revealed concurrent induction of actin cytoskeleton and motility programs and repression of chromosome condensation and mitotic modules in PKN2 cKO hearts. These molecular changes coincided with reduced cardiomyocyte proliferation at E10.5 E11.5 and early divergence in ventricular shape trajectories. Inducible cardiomyocyte specific PKN2 knockout hearts analyzed by quantitative light-sheet microscopy based morphometrics pinpointed the critical dependence window: recombination induced at E7.5 reproduced the ventricular geometry characteristic of constitutive PKN2 cKO hearts, whereas induction at E10.5 spared gross morphology. Together, these data show that cardiomyocytes depend on PKN2 during an early proliferative and migratory phase that drives ventricular wall formation, after which PKN2 becomes dispensable for heart morphogenesis. This temporally restricted requirement reconciles previous observations of PKN2s essential role in mesodermal and epithelial morphogenesis, suggesting a shared function in coordinating cytoskeletal remodeling with tissue expansion during organogenesis.
2026 · Open MIND · Chen, Ju
- 2025
2025 · Journal of Assisted Reproduction and Genetics · Roman, Iulian, Coull, Graham D., Michielsen, Adriana J. et al.
- 2025
2025 · Insect Molecular Biology · Pizarro, Tania Chavarria, Errbii, Mohammed, Rinke, Janina et al.
- 2025
2025 · Agronomy · Ba, Liangjie, Luo, Chenglin, Wang, Xiaogang et al.
- 2025
2025 · Brain Conflux · Liu, Nana, Liu, Yuting, Wang, Sijia et al.
- 2025
2025 · Frontiers in Plant Science · Liu, Xiulin, Wang, Xueyang, Zhang, Chunlei et al.
- 2025
2025 · Journal of the Advances in Agricultural Researches/Journal of the Advances in Agricultural Researches · Massoud, Magdy A., Mesbah, H. A., Bakr, Anar et al.
- 2025
Metabolites detected at specific developmental stages.
2025 · Figshare · (130663), Martin Sládek, (634836), Pavel Houdek, (18859002), Tomáš Čajka et al.
- 2025
2025 · Neurological Research · Nasiri, Mahdieh, Behrooz, Amir Barzegar, Adeli, Soheila et al.
- 2025
2025 · Current Biology · Gümüşderelioğlu, Selin, Sahabandu, Natalie, Elnatan, Daniel et al.
- 2025
2025 · Insect Science · Wu, Jiangli, Wei, Qiaohong, Sun, Jiajing et al.
- 2025
Developmental stage–specific expression and localization of p57Kip2 in the mouse placenta
2025 · Placenta · Tabuse, Mari, Nakamura, Hitomi, Tanaka, Yoshitomo et al.
- 2025
2025 · Poultry Science · Ouyang, Qingyuan, Li, Jing, Song, Yuanbo et al.
- 2025
2025 · Plant Biotechnology · Nakamura, Naoto, Sugiyama, Akifumi