Recent papers on Safety and Off target Effects

Sorted by publication year (newest first) via OpenAlex. List regenerates every 24h.

1. Abstract 3150: InVEST44™ is a cost-effective <i>in vitro</i> safety panel that identifies off-target effects in early-stage drug discovery

   2026 · Cancer Research · Wooltorton, Julian R. A., Ahona, Afsara, Barbacane, Nicole et al.

   2026

2. 26-A-12106-ACC LIPOPROTEIN(A)-TARGETED THERAPIES VERSUS PLACEBO/STANDARD CARE IN ASCVD: EFFECTS ON MACE, LP(A) REDUCTION AND SAFETY — SYSTEMATIC REVIEW AND META-ANALYSIS OF RCTS

   2026 · Journal of the American College of Cardiology · Onadipe, Oluwasolabomi, Yüce, Servet, Lanka, Nidhi et al.

   2026

3. Low-intensity focused ultrasound targeting striatal circuits in schizophrenia: feasibility, safety, and effects on hallucinations and striatal-temporal functional connectivity

   2026 · Brain stimulation · Subramaniam, Karuna, Attalla, Grace, Mathew, Miriam et al.

   2026

4. De-TarDis: Decoy-Target Discovery Database Integrating Off-Targets, Promiscuity, Adverse/Side-Effects, and Screening Panels via Reciprocal Rank Fusion for Safety Assessment

   2026 · International Journal of Advances in Engineering and Pure Sciences · Ugurlu, Sadettin Y.

   2026

5. First-in-human low-intensity focused ultrasound targeting striatal circuits in schizophrenia: feasibility, safety, and effects on hallucinations and striatal-temporal functional connectivity

   2026 · medRxiv · Subramaniam, Karuna, Attalla, Grace, Mathew, Miriam et al.

   2026

6. KT-621, an Oral, Once Daily, Targeted STAT6 Degrader: First-in-Human Phase 1a Safety, Pharmacokinetics, Pharmacodynamics and Th2 Biomarker Effects

   2025 · SKIN The Journal of Cutaneous Medicine · Shabbir, Arsalan, Agarwal, Sagar, McDonald, Alice et al.

   2025

7. Operational Methyl Bromide Fumigation Trials and Residue Assessment in Sukkur and Khairpur Date Godowns: Efficacy Against Saw-toothed Grain Beetle (Oryzaephilus surinamensis), Non-Target Effects, and Worker Safety

   2025 · Indus journal of bioscience research. · Kousar, Tasneem, Memon, Zaibun-Nisa, Gul, H. et al.

   2025

8. What are the effects of treatment interruption and resumption on the efficacy and safety of targeted therapies like apalutamide in oncology patients?

   2025 · Zenodo (CERN European Organization for Nuclear Research) · Tripdatabase

   2025

9. Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies

   2025 · OncoImmunology · Schindler-Wnek, Katharina, Stahringer, Anika, Heimer, Nadine et al.

   2025

10. LB0008 SAP-001, A FIRST –IN-CLASS COMPOUND TARGETING A RENAL URATE TRANSPORTER, SHOWS POTENT SERUM URATE-LOWERING EFFECTS AND FAVORABLE SAFETY PROFILE IN A US PHASE 2b STUDY IN PATIENTS WITH REFRACTORY GOUT WITH OR WITHOUT PALPABLE TOPHI

    2025 · Annals of the Rheumatic Diseases · Cui, Shujuan, Arencibia, C. González, Li, Li et al.

    2025

11. hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels

    2025 · Journal of Pharmacological and Toxicological Methods · Gordon, Earl, Cato, Matthew J., Chaudhary, Khuram W.

    2025

12. Assessment of Hsp90β-selective inhibitor safety and on-target effects

    2025 · Scientific Reports · Reynolds, Tyelor S., Mishra, Sanket J., Blagg, Brian S. J.

    2025

13. Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial

    2025 · Drug Design Development and Therapy · Liu, Yixian, Li, Xiaoyu, Zhang, Mengyu et al.

    2025

14. Without Progress, There Is Only Regression: A Study of the Spatial Spillover Effects of Work Safety Target Assessments

    2024 · China Public Administration Review · WANG, Fanfan

    2024

15. Environmental safety assessment of cumic acid: A comprehensive study on environmental behaviours and toxicological effects on non-target organisms

    2024 · The Science of The Total Environment · Yue, Mingxing, Li, Ting, Huang, Yuan et al.

    2024

16. Target Position and Safety Margin Effects on Path Planning in Obstacle Avoidance

    2024 · SSRN Electronic Journal · Saeedpour-Parizi, Mohammad R., Hassan, Shirin E., Azad, Ariful et al.

    2024

17. C-X-C Motif Chemokine Receptor 4–Targeted Radioligand Therapy in Hematological Malignancies—Myeloablative Effects, Antilymphoma Activity, and Safety Profile

    2023 · Clinical Nuclear Medicine · Dreher, Niklas, Dörrler, Anna-Lena, Kraus, Sabrina et al.

    2023

18. Abstract 12564: Safety, Pharmacokinetics, and Lipid Lowering Effects of the Oral, Liver-Targeted Liver X Receptor (LXR) Inverse Agonist TLC-2716 in Healthy Volunteers

    2023 · Circulation · Gane, Edward, Huss, Ryan S., Sur, Jane et al.

    2023

19. Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

    2023 · Journal of the American Chemical Society · Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu et al.

    2023

20. Effects of different targeted therapies associated with adjuvant chemotherapy on clinical remission, survival and safety in patients with triple-negative breast cancer: a systematic review and meta-analysis.

    2023 · PubMed · Li, J-G, Zhao, A-X, Tan, Z-Q et al.

    2023

21. Extent of safety database in pediatric drug development: types of assessment, analytical precision, and pathway for extrapolation through on-target effects

    2023 · Journal of Biopharmaceutical Statistics · Gamalo, Margaret, Zhao, Yihua, Gao, Aijun et al.

    2023

22. Targeting adverse effects of antiseizure medication on offspring: current evidence and new strategies for safety

    2023 · Expert Review of Neurotherapeutics · Sha, Leihao, Yong, Xihao, Shao, Zhenhua et al.

    2023

23. The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia

    2022 · International Journal of Molecular Sciences · Jastrzębska‐Więsek, Magdalena, Kotańska, Magdalena, Grzeszczak, A. et al.

    2022

24. Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers

    2022 · Current Opinion in Food Science · Wang, Dongxu, Wang, Taotao, Zhang, Zhihong et al.

    2022

25. Safety, Target Engagement and Effects of Bosutinib in Dementia with Lewy Bodies (S20.010)

    2022 · Neurology · Pagán, Fernando, Torres‐Yaghi, Yasar, Hebron, Michaeline et al.

    2022

26. Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies

    2022 · Alzheimer s & Dementia Translational Research & Clinical Interventions · Pagán, Fernando, Torres‐Yaghi, Yasar, Hebron, Michaeline et al.

    2022

27. Using transcriptome Shannon entropy to evaluate the off-target effects and safety of insecticidal siRNAs

    2022 · Journal of Integrative Agriculture · Ma, Weihua, Wu, Tong, ZHANG, Zan et al.

    2022

28. GENERAL SAFETY ISSUES SURROUNDING B-CELL TARGETED THERAPIES, UNDESIRABLE EFFECTS OF THERAPIES, AND TREATMENT CONSIDERATIONS

    2022 · Turkiye Klinikleri eBooks · TAŞTEKİN, FATİH, Aksu, Kenan

    2022