Recent papers on clinical characterization targeting safety target

Sorted by publication year (newest first) via OpenAlex. List regenerates every 24h.

1. EPITOPE-EDITED HEMATOPOIETIC STEM CELLS & CAR T CELLS TARGETING PAN-HEMATOLOGIC ANTIGEN CD45 INDUCE CONFORMATIONAL CHANGES THAT AFFECT FLOW CYTOMETRY SPECIFICITY IN CLINICAL PRODUCT CHARACTERIZATION WITH SPECIFIC ANTIBODY PARATOPE

   2026 · Cytotherapy · Mackey, S., Dai, A., Herbst-Nowrouzi, F. et al.

   2026

2. Polymeric Nanoparticles for Targeted Anticancer Therapy: Advances, Characterization, and Clinical Translation

   2026 · International Journal of Pharmacy and Pharmaceutical Science · Kankate, Achal, Mandave, Prachi S., Barsagade, Anup et al.

   2026

3. Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis

   2026 · BMC Medicine · Sui, Xin-Yi, Song, Xiao-Qing, Liu, Xi-Yu et al.

   2026

4. Clinical Characterization and Molecular Profiling by Targeted Next‐Generation Sequencing in a Large Indian Cohort With 46,XY Differences in Sex Development

   2026 · Clinical Endocrinology · Jain, Vandana, Priyadarshini, Sukanya, Sharma, Rajni et al.

   2026

5. Characterizations, genomic analysis, and antibioflim efficacy study of novel broadspectrum virulent bacteriophages Sfin-3, Sfin-4, and Sfin-5 targeting MDR clinical isolates of Shigella spp

   2026 · Research Square · Guin, Chiranjib, Das, Bidisha, Rai, Srijana et al.

   2026

6. 1146 The Clinical, Immunophenotypic, and Genetic Characterization of Pediatric Acute Leukemia with CD70 Expression: A Potential Role for CD70-Targeted Therapy

   2026 · Laboratory Investigation · Adkins, Jesse, Gardner, Dominique, Wang, Wei et al.

   2026

7. Proteogenomic characterization of cervical cancer identifies molecular subtypes predictive of clinical outcomes and subtype-specific targets

   2026 · Journal of Clinical Investigation · Tian, Xun, Li, Mansheng, Wang, Zhi et al.

   2026

8. Clinical characterization and targeted genetic mutation profiling of autoimmune disease–associated B-cell lymphoma

   2026 · Discover Oncology · Di, Hongchen, Wang, Zixin, Ma, Rongjun et al.

   2026

9. Clinical characterization of Chlamydia psittaci infections detected by targeted next generation sequencing in a Chinese tertiary hospital

   2026 · Frontiers in Medicine · Song, Yu, Feng, Ruli, Sun, Liying et al.

   2026

10. Clinical PK characterization of EGT710, a novel coronavirus Mpro inhibitor, and simulation of target attainment rates for efficacious dose prediction

    2026 · Ghanshani, Swati, Gaudet, Suzanne, Bebrevska, Lidiya et al.

    2026

11. Food is a chemically complex matrix comprised of macronutrients, micronutrients, and thousands of small, bioactive metabolites. Emerging omics technologies have revealed that these metabolites influence flavor, nutritional quality, and human health. Yet, many bioactive small molecules associated with beneficial health outcomes are chemically labile, making appropriate sample preservation critical. Following existing standards from clinical research, storage at -80 C is widely used in foodomics to minimize enzymatic activity and metabolite degradation. Yet, the viability of these conditions to the biological and chemical diversity of food has yet to be rigorously evaluated. This study investigates how storage temperature affects the stability of metabolites in eleven different foods: cocoa powder, milk chocolate, ground beef, apple, carrot, beet leaf, beet root, potato, and both uncooked and cooked rice. Prepared food samples were divided for storage at 25 C, 4 C, and -20 C, with -80 C samples serving as a baseline. Samples were collected at three and six months from each storage condition to assess metabolite stability over time. Analysis of all samples was performed by nontargeted metabolomics and targeted LC-PDA analysis of carotenoids. Our results showed that metabolite stability was matrix dependent, with some foods (i.e. provide food names) showing significant variation in global metabolome profiles while others (i.e. provide food names) had no observable differences. Collectively, these findings suggest that sample preservation is essential for maintaining metabolite integrity in food matrices and must be carefully considered to ensure accurate characterization of food metabolic profiles.

    2026 · Open MIND · Prenni, Jessica

    2026

12. Performance and clinical utility of two targeted multigene panels for GIST molecular characterization

    2025 · Scientific Reports · Nannini, Margherita, Astolfi, Annalisa, Maloberti, Thais et al.

    2025

13. Table 1_Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.docx

    2025 · Figshare · (18883), Qian Chen, (13729363), Yifan Qiu, (846358), Jintao Zhang et al.

    2025

14. Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance

    2025 · Frontiers in Cellular and Infection Microbiology · Chen, Qian, Qiu, Yifan, Zhang, Jintao et al.

    2025

15. Table 2_Nanopore targeted sequencing in lower respiratory infections: a retrospective study on diagnostic applications, clinical characterization, and antimicrobial guidance.docx

    2025 · Figshare · (18883), Qian Chen, (13729363), Yifan Qiu, (846358), Jintao Zhang et al.

    2025

16. 346 Pre-clinical characterization of AZD0240, a CRISPR-engineered autologous TCR-T cell product targeting KRAS-G12D/HLA-A*11:01 that is multi-armored to increase epitope sensitivity

    2025 · Regular and Young Investigator Award Abstracts · Kok, Lianne, Eshuis, Sander, Kong, Xiangjun et al.

    2025

17. Biological characterization and stability of three lytic wastewater-derived bacteriophages targeting multidrug-resistant Acinetobacter baumannii and A. johnsonii clinical strains

    2025 · Microbiological Research · Cieślik, Martyna, Bajrak, Olaf, Wójcicki, Michał et al.

    2025

18. Formulation, Phytochemical Characterization, and Clinical Assessment of a Novel Natural Supplement Targeting Body Composition in Physically Active Individuals: A Randomized Clinical Trial

    2025 · Kurdistan Journal of Applied Research · salih, Tablo Azad Hama, Farag, Halgord Ali M.

    2025

19. 25P Comprehensive clinical and molecular characterization of triple-positive breast cancer: Refining criteria for FGFR-targeted therapy with PAM50 intrinsic subtyping

    2025 · ESMO Open · Braun, Marcin, Galikowska, B., Tomasik, Bartłomiej et al.

    2025

20. Abstract 3478: Pre-clinical characterization of AZD0240, a CRISPR-engineered autologous TCR-T cell product targeting KRAS-G12D/HLA-A*11:01 that is multi-armored to increase epitope sensitivity

    2025 · Cancer Research · Kok, Lianne, Eshuis, Sander, Kong, Xiangjun et al.

    2025

21. Analytical and Real‐World Clinical Characterization of S2,3PSA% Test in MRI Fusion Targeted Prostate Biopsy Population

    2025 · The Prostate · Miura, Yuki, Yoneyama, Tohru, Yamamoto, Hayato et al.

    2025

22. Clinical characterization and therapeutic targeting of fusion genes in oncology

    2025 · Future Oncology · Morand, Susan, Rager, Lauren Elizabeth, Craig, Daniel J. et al.

    2025

23. Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4

    2025 · Molecular Pharmacology · Pan, Kylie S., Wang, Ziming, Pfeil, Cy et al.

    2025

24. Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma

    2025 · Biomedicines · Long, Hezhou, Zhou, Jiafu, Zhou, Changxia et al.

    2025

25. High-resolution targeted mass spectrometry for comprehensive quantification of sphingolipids: clinical applications and characterization of extracellular vesicles

    2024 · Analytical Biochemistry · Defelippo-Felippe, Thiago V., Toro, Diana Mota, Carvalho, Jonatan C. S. de et al.

    2024

26. A Comprehensive Whole Genome Sequencing Assay Provides Robust Characterization of Clinically Relevant Genomic Alterations across Myeloid Malignancies Concordant with Matched Results from Targeted DNA, Whole Transcriptome RNA and Cytogenetic Profiling

    2024 · Blood · Huether, Robert, Hoskinson, Derick, Anur, Pavana et al.

    2024

27. Nano-vesicular systems for melanocytes targeting and melasma treatment: In-vitro characterization, ex-vivo skin retention, and preliminary clinical appraisal

    2024 · International Journal of Pharmaceutics · Hatem, Shymaa, Kamel, Amany O., Elkheshen, Seham A. et al.

    2024

28. Synthesis, Photo-Characterizations, and Pre-Clinical Studies on Advanced Cellular and Animal Models of Zinc(II) and Platinum(II) Sulfonyl-Substituted Phthalocyanines for Enhanced Vascular-Targeted Photodynamic Therapy

    2024 · ACS Applied Materials & Interfaces · Repetowski, Paweł, Warszyńska, Marta, Kostecka, Anna et al.

    2024

29. Nonclinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1

    2024 · American Journal of Transplantation · Abend, Johanna R., Sathe, Atul, Wrobel, Matthias B. et al.

    2024

30. Pre-clinical Pharmacology and Tolerability Characterization of a Novel KIRxICOS Targeting Bispecific CD8 Treg Modulator

    2024 · The Journal of Immunology · Pham, Thi Minh Nguyet, Bogatzki, Lisa, Boster, Dan et al.

    2024