Recent papers on exposure tissues microplastics metabolic disease

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Tissue-specific accumulation and human exposure risk of microplastics in the edible clam Meretrix petechialis
2026 · Journal of Food Composition and Analysis · Sun, Jiayi, Xuan, Sheng, Chen, Xiaomei et al.
2026
Combined exposure to microplastics and pesticides with endocrine-disrupting potential: evidence of interaction, reproductive biomarkers, and tissue bioaccumulation in humans and animal models
2026 · OSF Preprints (OSF Preprints) · Alcántara, Ruth López, Yabur, Adib Antonio Olvera, Yabur, Adib Antonio Olvera et al.
2026
In vitro effects of polystyrene microplastics exposure on adipose tissue dysfunction
2026 · Toxicology in Vitro · Molonia, Maria Sofia, Trischitta, Santi, Salamone, Federica Lina et al.
2026
Microplastic Accumulation and Tissue Translocation in Freshwater and Aquaculture fish: Environmental Distribution and Human Exposure Assessment
2026 · SSRN Electronic Journal · Lee, Ching-Chang, Lu, Quang-Oai, Jordaan, Adrian et al.
2026
Plastics and their products in our everyday environment have become a global problem and an integral part of life, and the extent of exposure and potential toxic effects of these pollutants on several human organs are becoming increasingly evident. We hypothesize that polyethylene terephthalate (PET) disrupts the function of the adrenal cortex in immature piglets. The study was approved by the Local Ethics Committee of the University of Warmia and Mazury in Olsztyn (decision No. 10/2020 of 26 February 2020) and conducted in accordance with the provisions of the European Union directive on the ethical use of experimental animals (EU Directive 2010/63/EU for animal experiments). All animals were housed in breeding pens under standard laboratory conditions (temperature was maintained at 20-22 degree Celsius, and humidity ranged from 55 % to 60 %) and were provided with free access to fresh water (ad libitum) and an age-appropriate feed mixture. All plastic items were removed from the animals environment. The equipment on the farm where the gilts were raised before the experiment was also made of stainless steel. The experiment lasted 4 weeks and was conducted on 8-week-old (Pietrain x Duroc) immature gilts (n = 15) with an estimated body weight of 20 kg. The animals were divided into three groups: 1) control group (CTRL; n = 5) which received empty gelatin capsules per os; 2) experimental group (LD; n = 5) which received a low dose of PET MPs (0.1 g/pig/day in gelatin capsules) per os; 3) experimental group (HD; n = 5) which received a high dose of PET MPs (1 g/pig/day in gelatin capsules) per os. The microplastics used for the experiment is a semi-crystalline polyethylene terephthalate powder (Goodfellow Cambridge Ltd., Huntingdon, England). The particles have different shapes (spherical, fibrous, irregular) with the average length of the larger side of the molecule 153.09 um. The applied doses were selected based on weekly human consumption of MPs reported in the literature (0.1-5 g of MPs per week) as well the previous toxicological studies of mice and aquatic organisms (Deng et al., 2017a, Senathirajah et al., 2021). The low dose was adjusted to the weight of gilts, whereas the high dose was 10 times higher than the low dose to determine the effect of MP accumulation (calculated on a logarithmic scale) (Yang et al., 2019). Immediately after euthanasia the adrenals were isolated and frozen in liquid nitrogen. In the laboratory of the Department of Animal Anatomy and Physiology, the adrenal cortex was mechanically separated from the medulla under a stereomicroscope and stored -80 degree Celsius for further analyses. Protein extraction was performed using T-PER Tissue Protein Extraction Reagent (Thermo Fisher Scientific, Waltham, MA, USA) supplemented with a protease inhibitor cocktail (Sigma-Aldrich, Merck Group, Darmstadt, Germany), according to the manufacturers instructions. Protein concentration was determined using the bicinchoninic acid (BCA) assay (Pierce BCA Protein Assay Kit, Thermo Fisher Scientific). Samples containing 150 ug of total protein were transported to the Department of Biochemistry and Molecular Biology, University of Southern Denmark. For proteomic analysis, 50 ug of protein per sample was reduced with dithiothreitol (DTT) and alkylated with iodoacetamide (IAA) (both from Sigma-Aldrich), followed by digestion with sequencing-grade modified trypsin (Sigma-Aldrich) at a dose of 2.5 ug. Digestion was performed overnight at 37 degree Celsius. The reaction was terminated by the addition of 20% trifluoroacetic acid (TFA) (Sigma-Aldrich), and the pH was adjusted to pH 3. Peptides were desalted using Evotips according to the manufacturers protocol. Peptide separation was performed using an Evosep One LC system (Evosep ApS, Odense, Denmark) coupled to an Orbitrap Astral mass spectrometer (Thermo Fisher Scientific). 0.1 ug of peptides was loaded per Evotip. LC MS/MS data acquisition was performed in data-independent acquisition (DIA) mode, and data analysis was conducted using the directDIA workflow implemented in Spectronaut software (Biognosys, Zurich, Switzerland). The MS RAW-files were analyzed using Spectronaut v20.3 (Biognosys AG, Schlieren) with directDIA using default search settings against a FAST file containing the pig proteome (UniProt, 22,804 sequences, downloaded November 2025).
2026 · Open MIND · Iwona, Bogacka
2026
Co-exposure to Hexavalent Chromium and Polyamide Microplastics Alters Growth, Hematology, Histopathology of Tissues and Immune Genes Expression in Striped Catfish (Pangasianodon hypophthalmus)
2025 · Biological Trace Element Research · Shahriar, Sheik Istiak Md, Zannat, Md Meftahul, Zahangir, Md. Mahiuddin et al.
2025
Polystyrene microplastics (PS-MPs) disturb skeleto-muscular energy metabolism and tissue architecture following sub-acute exposure: A dose-responsive study
2025 · Journal of Muscle Research and Cell Motility · Chakraborty, Susmita, Pal, Sudipta
2025
Microplastic exposure induces structural hyperplasia in the gill tissue of grass carp (Ctenopharyngodon idellus) through immunosuppression, metabolic disruption, and structural damage
2025 · Aquatic Toxicology · Zhang, Fubin, Chen, Xueting, Huang, Shuting et al.
2025
[Effects of microplastics exposure in development of mineralized tissues].
2025 · PubMed · Yu, Si-Han, Zheng, Liwei, Wan, Mian
2025
Co-exposure toxicity of microplastic and sumithion in Nile tilapia – changes in growth, hematology, histopathology of internal tissues and immune-antioxidant genes expression
2025 · Journal of Hazardous Materials Advances · Haque, Md Ahsanul, Anwar, M. Choiroel, Hossain, AKM Afzal et al.
2025
Alteration of growth, hematology, histopathology of tissues and immune-antioxidant genes expression in Nile tilapia following co-exposure of hexavalent chromium and polyamide microplastics
2025 · Ecotoxicology · Islam, Naimul, Shahriar, Sheik Istiak Md, Noor, Shifat Ara et al.
2025
Distribution and Tissue Damage After a Single Microplastic Exposure in Mice
2025 · Egyptian Academic Journal of Biological Sciences. D, Histology and Histochemistry · Chen, Xinyuan, Wang, Chenxiao, Shen, Yongyi et al.
2025
Dietary exposure to microplastic via shellfish and the importance of the edible shellfish tissue measurements
2025 · Vankoningsloo, M., Andjelković, Mirjana, Stanić-Vučinić, Dragana et al.
2025
Plastic exposure may be associated with the deposition of microplastics in reproductive tissues and adverse clinical outcomes
2024 · Evidence-Based Nursing · Phillipi, Michael, Caughey, Aaron B.
2024
Effect of Polystyrene Microplastic Exposure on Individual, Tissue, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)
2024 · Fishes · Huang, Yuequn, Li, Wenjing, Li, Wenjing et al.
2024
An Analysis of Suspected Microplastics in the Muscle and Gastrointestinal Tissues of Fish from Sarasota Bay, FL: Exposure and Implications for Apex Predators and Seafood Consumers
2024 · Environments · Conger, Eric, Dziobak, Miranda, McCabe, Elizabeth J. Berens et al.
2024
Microplastic exposure reduced the defecation rate, altered digestive enzyme activities, and caused histological and ultracellular changes in the midgut tissues of the ground beetle (Blaps polychresta)
2024 · Journal of Insect Physiology · Kholy, Samar El, Ayorinde, Taiwo, Sayes, Christie M. et al.
2024
Microplastic co-exposure elevates cadmium accumulation in mouse tissue after rice consumption: Mechanisms and health implications
2024 · Journal of Hazardous Materials · Chen, Shan, Gan, H.P., Lin, Xin-Ying et al.
2024
Microplastics in different tissues of historical and live samples of endangered mega-fish (Acipenser sinensis) and their potential relevance to exposure pathways
2024 · Aquatic Toxicology · Zheng, Yueping, Huang, Sirui, Fan, Houyong et al.
2024
In Vivo Tissue Distribution of Microplastics and the Systemic Metabolic Changes After Gastrointestinal Exposure in Mice
2024 · Physiology · Romero, Aaron S.
2024
Chronic exposure to low concentrations of microplastics causing gut tissue damage but non-significant changes in the microbiota of marine medaka larvae (Oryzias melastigma)
2024 · Marine Environmental Research · Wen, Shaobai, Yin, Xiuran, Zhang, Yankun et al.
2024
Bioaccumulation of microplastics in the edible tissues of fish collected from urban lakes of Bangladesh: a potential exposure to public health
2023 · Environmental Science and Pollution Research · Nath, Jayasree, Parvin, Fahmida, Tareq, Shafi M.
2023
In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure
2023 · bioRxiv (Cold Spring Harbor Laboratory) · Garcia, Marcus, Romero, Aaron S., Merkley, Seth D. et al.
2023
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
2022 · PubMed · Yang, Zuo Sen, Bai, Ying Long, Jin, Cui Hong et al.
2022
Corrigendum to “Occurrence and exposure analysis of microplastic in the gut and muscle tissue of riverine fish in Kermanshah province of Iran” [Mar. Pollut. Bull. 173 (2021) 112915]
2022 · Marine Pollution Bulletin · Makhdoumi, Pouran, Hossini, Hooshyar, Nazmara, Zohreh et al.
2022
Toxicity and Functional Tissue Responses of Two Freshwater Fish after Exposure to Polystyrene Microplastics
2021 · Toxics · Kaloyianni, Martha, Bobori, Dimitra, Xanthopoulou, Despoina et al.
2021
Occurrence and exposure analysis of microplastic in the gut and muscle tissue of riverine fish in Kermanshah province of Iran
2021 · Marine Pollution Bulletin · Makhdoumi, Pouran, Hossini, Hooshyar, Nazmara, Zohreh et al.
2021
Toxic effects of exposure to microplastics with environmentally relevant shapes and concentrations: Accumulation, energy metabolism and tissue damage in oyster Crassostrea gigas
2020 · Environmental Pollution · Teng, Jia, Zhao, Jianmin, Zhu, Xiaopeng et al.
2020

Recent papers on exposure tissues microplastics metabolic disease

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