medicine35 papersavg year 2025quality 5/5

establish relationships infection functional demographic

Research gap analysis derived from 35 medicine papers in our local library.

The gap

The study population and demographic characteristics (age range, comorbidities, race/ethnicity, geographic origin) are not described in the provided excerpt. Validation of the serum uric acid-heart failure severity relationship across diverse populations (African, Asian, Caucasian cohorts) and different geographic settings is required to establish generalizability beyond the original Kufa University cohort.; The lack of placental pathological examination constitutes a major methodological...

Research trend

Emerging — attention growing, methods still coalescing.

Supporting evidence — 8 representative gaps

  • Fibroepithelial lesions: assessing the risk of malignant phyllodes tumors in the breast (2025) · doi

    Further evaluation by MRI is sometimes required to establish correct differentiation between phyllodes tumors and fibroadenomas, but the optimal criteria for when MRI should be used remain unclear.

    Keywords: further evaluation sometimes required establish correct differentiation phyllodes tumors fibroadenomas optimal criteria used remain unclear
  • Fibroepithelial lesions: assessing the risk of malignant phyllodes tumors in the breast (2025) · doi

    Sonoelastography has shown promising results for tumors less than 3 cm, but further investigation is needed to establish its broader applicability and standardization.

    Keywords: sonoelastography promising tumors less further investigation needed establish broader applicability standardization
  • A rare case of multiple autoimmune syndrome after sars-cov2 infection (2022) · doi

    Further research is needed to establish the relationship between COVID-19 infection and rheumatic autoimmune diseases such as SLE and MCTD, as current documentation is limited.

    Keywords: further needed establish relationship covid infection rheumatic autoimmune diseases mctd current documentation limited
  • Thymus pathology in myasthenia gravis with anti-acetylcholine receptor antibodies and concomitant Hashimoto’s thyroiditis. A four-case series and literature review (2021) · doi

    The heterogeneous pattern of thymic lesions across different MG subtypes suggests the need for larger sample sizes to establish consistent morphological patterns.

    Keywords: heterogeneous pattern thymic lesions across different subtypes suggests need larger sample sizes establish consistent morphological
  • Elevated growth differentiation factor-15 in sepsis: clinical associations and immune cell context (2026) · doi

    The results are most consistent with the interpretation that circulating GDF-15 tracks integrated physiological stress, but the study does not establish a causal or predictive role for GDF-15 in sepsis.

    Keywords: consistent interpretation circulating tracks integrated physiological stress establish causal predictive role sepsis
  • Photodynamic Therapy in Otorhinolaryngology: Current Evidence, Clinical Applications and Future Perspectives (2026) · doi

    While PDT shows promising antiviral effects for conditions like SARS-CoV-2, further research is needed to establish its role in infection control during viral epidemics in community ENT practice.

    Keywords: shows promising antiviral effects conditions like sars further needed establish role infection control viral epidemics
  • The impact of adenomyosis localization in myometrium on fertility and pregnancy outcomes: a narrative systematic review of the literature (2026) · doi

    Further research is needed to establish clear predictors of adenomyosis subtypes beyond the factors identified (DIE/SUP, OMA, and prior abortion history) in limited studies.

    Keywords: further needed establish clear predictors adenomyosis subtypes beyond factors identified prior abortion history limited
  • Successful azithromycin treatment of Chlamydia psittaci pneumonia in second-trimester pregnancy resulting in term delivery: a case report (2026) · doi

    The lack of placental pathological examination constitutes a major methodological limitation. Despite the favorable neonatal outcome, the absence of pathological evidence precluded confirmation of placental involvement, which limited the ability to establish a definitive causal relationship between perinatal infection routes and maternal-fetal outcomes.

    Keywords: placental pathological lack examination constitutes major methodological limitation despite favorable neonatal outcome absence evidence precluded

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