multiple individual pathways simultaneously talk
Research gap analysis derived from 2 biology papers in our local library.
The gap
While epistatic interactions and genetic interactions have been characterized in individual evolutionary repair experiments (e.g., reciprocal sign epistasis, diminishing returns epistasis), systematic mapping of epistatic architectures across multiple cellular pathways simultaneously during experimental evolution has not been conducted.; Most studies focus on individual signaling pathways (PI3K/AKT, NF-κB, MAPK/p38, etc.); comprehensive understanding of how osthole simultaneously modulates...
Research trend
Emerging — attention growing, methods still coalescing.
Supporting evidence — 2 representative gaps
- Osthole: A Coumarin with Dual Roles in Biology and Chemistry (2025) · doi
Most studies focus on individual signaling pathways (PI3K/AKT, NF-κB, MAPK/p38, etc.); comprehensive understanding of how osthole simultaneously modulates multiple pathways and their cross-talk is lacking.
Keywords: pathways focus individual signaling mapk comprehensive understanding osthole simultaneously modulates multiple cross talk lacking - Experimental evolution for cell biology (2023) · doi
While epistatic interactions and genetic interactions have been characterized in individual evolutionary repair experiments (e.g., reciprocal sign epistasis, diminishing returns epistasis), systematic mapping of epistatic architectures across multiple cellular pathways simultaneously during experimental evolution has not been conducted.
Keywords: epistasis genetic interactions reciprocal sign epistasis pathway mapping experimental evolution
Working on this gap? Publish with us.
Science AI Journal reviews manuscripts in under 15 minutes with 8 specialised AI reviewers calibrated on 23,000+ real peer reviews. Open access, CC BY 4.0.
Related gaps in biology
- predictive extreme value field externalFurther investigation is needed to replicate the model in larger, more diverse cohorts, including female athletes, young athle…
- site capture differences management trueWhile the paper references agricultural intensification and forest management as drivers of passerine population changes (citing Reif et al.…
- financial sector institution sectors managementThe paper documents that leverage (LEV) exhibits a positive coefficient (1.525-1.472) driven by tax shield benefits but issues a cautionary …
- excerpt discussion directions explicit withoutThe excerpt provided contains only supporting spectral information and DFT frequency calculations without explicit discussion of research ga…