Although their regulatory mechanisms in chronic infection are not understood, further study would provide insight not only into the role of these antibodies in the pathogenesis of periodontitis but al

The gap

Consensus across the literature

Supporting evidence — 4 representative gaps

• Ethics in Academe--Afton Dekanal. (1984) · doi

  Although their regulatory mechanisms in chronic infection are not understood, further study would provide insight not only into the role of these antibodies in the pathogenesis of periodontitis but also into the possible link between periodontitis and systemic diseases such as coronary heart disease.

  Keywords: periodontitis regulatory mechanisms chronic infection understood further provide insight role antibodies pathogenesis possible link systemic
• Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions (2021) · doi

  Although the association between herpesviruses and periodontitis and the degree to which these viruses directly aggravate periodontal tissue damage remain unclear, the benefits to periodontal health found from prolonged administration of antivirals in immunocompromised or immunodeficient individuals demonstrates that specific populations are possibly more susceptible to viral periodontopathogens.

  Keywords: periodontal association herpesviruses periodontitis degree viruses directly aggravate tissue damage remain unclear benefits health found
• Impact of SARS-CoV-2 on periodontal tissue manifestation (2020) · doi

  Although COVID-19 might manifest in periodontal tissues, presence of periodontal pathogen could pose a risk of superinfection, and periodontal pocket could be a favorable anatomical niche for the virus, the literature is still lacking to conclude that COVID-19 has an impact on periodontal tissues and more studies are needed.

  Keywords: periodontal covid tissues manifest presence pathogen pose risk superinfection pocket favorable anatomical niche virus literature
• Current evidence and biological plausibility linking periodontitis to atherosclerotic cardiovascular disease (2014) · doi

  Although the causal mechanisms by which periodontitis accelerates ACVD have not been fully elucidated, plausible evidence regarding the inflammatory response due to inflammatory mediators and bacterial etiologies, and the recognition of altered lipid metabolism in patients with periodontitis suggest that infection with periodontopathic bacteria can influence atherogenesis in vitro and in vivo.

  Keywords: periodontitis inflammatory causal mechanisms accelerates acvd fully elucidated plausible evidence regarding response mediators bacterial etiologies