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general3 papersavg year 2026quality 4/5moderate evidence

Clinical Research Gaps

Research gap analysis derived from 3 general papers in our local library.

The gap

There is a need for larger, multicenter studies to validate findings across diverse populations in clinical research.

Consensus across the literature

The papers collectively establish the importance of broader sample sizes and generalizability but leave open specific methodological details and population considerations.

Research trend

Emerging — attention growing, methods still coalescing.

Supporting evidence — 6 representative gaps

  • ORGAN-SAVING APPROACHES IN THE SURGICAL CORRECTION OF AESTHETIC DEFORMATIONS OF THE NOSE (2026) · doi

    The study was limited to 95 patients selected from 462 primary rhinoplasties performed during 2016-2020, which represents a relatively small sample size.

    Keywords: limited patients selected primary rhinoplasties performed represents relatively small sample size
  • RESULTS OF THE STUDY OF THERAPEUTIC PATHOMORPHOSIS OF MALIGNANT EPITHELIAL TUMORS IN PATIENTS WITH LOCALLY ADVANCED RESECTABLE COLON TUMORS UNDER PREOPERATIVE CHEMORADIATION INDUCTION (2026) · doi

    The study was limited to 90 patients with locally advanced colon cancer at a single center; larger multicenter studies are needed to validate the findings across diverse populations.

    Keywords: limited patients locally advanced colon cancer single center larger multicenter needed validate across diverse populations
  • ANALYSIS OF METACHRONOUS MALIGNANT DISEASES IN BREAST CANCER PATIENTS (2026) · doi

    A risk calculation algorithm for metachronous tumors in patients with primary diagnosed breast cancer should be developed, taking into account all key factors.

    Keywords: risk calculation algorithm metachronous tumors patients primary diagnosed breast cancer developed taking account factors
  • ANALYSIS OF METACHRONOUS MALIGNANT DISEASES IN BREAST CANCER PATIENTS (2026) · doi

    Statistically significant data on metachronous gastric cancer have not yet been obtained.

    Keywords: statistically significant metachronous gastric cancer obtained
  • ANALYSIS OF METACHRONOUS MALIGNANT DISEASES IN BREAST CANCER PATIENTS (2026) · doi

    Further study of the interrelationship between breast cancer and metachronous cancers of the uterus, ovary, colon and stomach is necessary.

    Keywords: further interrelationship breast cancer metachronous cancers uterus ovary colon stomach necessary
  • ANALYSIS OF METACHRONOUS MALIGNANT DISEASES IN BREAST CANCER PATIENTS (2026) · doi

    Knowledge obtained should be directed toward improving screening and early diagnosis programs for both breast cancer and polyneoplasias.

    Keywords: knowledge obtained directed toward improving screening early diagnosis programs breast cancer polyneoplasias

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