Histologic transformation to lung squamous cell carcinoma (LUSC) is an underrecognized mechanism of resistance in epidermal growth factor receptor ( EGFR )–mutant lung adenocarcinoma (LUAD).
Research gap analysis derived from 3 biology papers in our local library.
The gap
Histologic transformation to lung squamous cell carcinoma (LUSC) is an underrecognized mechanism of resistance in epidermal growth factor receptor ( EGFR )–mutant lung adenocarcinoma (LUAD).
Consensus across the literature
Clustered from 3 gap mentions across 3 papers via embedding cosine ≥ 0.62.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- Histological transformation in lung cancer: a single-arm meta-analysis and systematic review (2026) · doi
Abstract Background Histological transformation represents an important mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant lung cancer; however, its incidence, timing, and post-transformation outcomes remain incompletely characterized.
Keywords: transformation egfr abstract background histological represents important mechanism acquired resistance epidermal growth factor receptor tyrosine - Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR (2010) · doi
BACKGROUND: Non-small-cell lung cancer with sensitive mutations of the epidermal growth factor receptor (EGFR) is highly responsive to EGFR tyrosine kinase inhibitors such as gefitinib, but little is known about how its efficacy and safety profile compares with that of standard chemotherapy.
Keywords: egfr background small cell lung cancer sensitive mutations epidermal growth factor receptor highly responsive tyrosine - Clinicogenomic analysis of <i>EGFR</i> -mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation (2026) · doi
Histologic transformation to lung squamous cell carcinoma (LUSC) is an underrecognized mechanism of resistance in epidermal growth factor receptor ( EGFR )–mutant lung adenocarcinoma (LUAD).
Keywords: lung histologic transformation squamous cell carcinoma lusc underrecognized mechanism resistance epidermal growth factor receptor egfr
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