To date, the sources, the release form and environmental fate and exposure of nano-enabled medical products have not been investigated and little or no data exists, although there are a small number o

The gap

Consensus across the literature

Supporting evidence — 3 representative gaps

• Nanotechnology-Driven Drug Delivery System: Recent Advances, Applications and Future Perspectives (2026) · doi

  Management: in Stability and Preservative Nano-sized colloidal suspension particles can undergo chemical degradation or aggregation during product preservation, which may also change their size and effectiveness of the product9. 4. Compliance and Ethical Barriers: As nanotechnology-based drugs are recently developed, compliance requirements their authorisation, evaluation, and safety assessment are still progressing. This endures their path from laboratory research to medicinal use6. for ISSN: 2250-1177 [188] CODEN (USA): JDDTAO Chandola et al. Journal of Drug Delivery & Therapeutics. 2026; 16(4):185-194 5. Restricted Follow-up Data: Mostly, the nano-scale based medical procedures are still initial clinical studies. Their under evaluation or prolonged effects on organs, biotransformation, and the immunological system are not yet clearly understood7. Table 2: Advantages and limitations of Nanotechnology ADVANTAGES

  Keywords: nano product compliance nanotechnology based evaluation still advantages management stability preservative sized colloidal suspension particles
• Overcoming barriers: mechanisms and strategies of nanoparticles in overcoming the blood-brain barrier and drug resistance in glioblastomas (2026) · doi

  Future research should focus on the development of multifunctional and personalized nanomedicine strategies, integration with multimodal therapies, and rigorous evaluation of long-term safety and clinical efficacy, in order to facilitate the successful translation of these technologies into clinical practice.

  Keywords: clinical future focus development multifunctional personalized nanomedicine strategies integration multimodal therapies rigorous evaluation long term
• Potential environmental implications of nano-enabled medical applications: critical review (2012) · doi

  To date, the sources, the release form and environmental fate and exposure of nano-enabled medical products have not been investigated and little or no data exists, although there are a small number of currently approved medical applications and a number in clinical trials.

  Keywords: medical number date sources release form environmental fate exposure nano enabled products investigated little exists