Translational Research Gaps

The gap

Consensus across the literature

Supporting evidence — 3 representative gaps

• From plant to gut: ussing chamber as a method for studying natural SGLT1 inhibitors in murine models (2026) · doi

  The studies reviewed include experiments in both mouse and rat models with varying intestinal segments (distal ileum, jejunum, proximal jejunum), but the translatability of these findings to human intestinal physiology and clinical applications requires further investigation.

  Keywords: intestinal jejunum reviewed include experiments mouse models varying segments distal ileum proximal translatability human physiology
• Fumarate inhibits the formation of neutrophil extracellular traps (NETs) in a Nrf2-controlled and Annexin-A1-dependent manner associated with mitochondrial fusion (2026) · doi

  The relevance of these findings to human pathological conditions such as sepsis requires validation in clinical or advanced in vivo models beyond the current experimental systems.

  Keywords: relevance human pathological conditions sepsis requires validation clinical advanced vivo models beyond current experimental systems
• Comparative effect of Kolaviron and Bryophyllum pinnatum extract on apoptotic biomarker in aluminium chloride-induced neurotoxicity in rats (2026) · doi

  Testing translatability to human populations is required to determine clinical relevance of these preclinical findings.

  Keywords: testing translatability human populations required determine clinical relevance preclinical