While the potential of serotonergic psychedelics and related substances as adjuncts in substance-assisted psychotherapy (SAPT) has been investigated for the treatment of several disorders, evidence fo

The gap

Consensus across the literature

Supporting evidence — 3 representative gaps

• Dosing and Therapeutic Conduct in Administration Sessions in Substance-Assisted Psychotherapy: A Systematized Review (2023) · doi

  While the potential of serotonergic psychedelics and related substances as adjuncts in substance-assisted psychotherapy (SAPT) has been investigated for the treatment of several disorders, evidence for the appropriate therapeutic conduct in administration sessions is sparse.

  Keywords: potential serotonergic psychedelics related substances adjuncts substance assisted psychotherapy sapt investigated treatment several disorders evidence
• Citalopram Combined with Behavioral Therapy Reduces Cocaine Use: A Double-Blind, Placebo-Controlled Trial (2007) · doi

  Promising findings from preclinical research on the effects of cocaine on serotonin lead to examination of selective serotonin reuptake inhibitors (SSRIs) as potential treatments for cocaine dependence with mixed results, possibly due to drug interactions or specifics of concomitant behavioral therapy.

  Keywords: cocaine serotonin promising preclinical effects lead examination selective reuptake inhibitors ssris potential treatments dependence mixed
• Selective Serotonin Reuptake Inhibitor-Induced Serotonin Syndrome (1997) · doi

  There are important pharmacokinetic interactions between SSRIs and other serotonergic drugs due principally to their effects on the cytochrome P450(CYP) isoenzymes, the potential for which varies widely amongst the SSRI group, which may increase the likelihood of a pharmacodynamic interaction.

  Keywords: there important pharmacokinetic interactions ssris serotonergic drugs principally effects cytochrome isoenzymes potential varies widely amongst