wide confidence intervals regarding estimates

The gap

Supporting evidence — 4 representative gaps

• Effects of noninvasive brain stimulation in the treatment of poststroke depression: an overview of systematic reviews (2026) · doi

  The GRADE system indicated that the quality of evidence was moderate, low, or very low, mainly due to flaws in the original RCTs regarding randomization, allocation concealment, and blinding, along with high heterogeneity, small sample sizes, and wide confidence intervals.

  Keywords: grade system quality evidence moderate mainly flaws original rcts regarding randomization allocation concealment blinding along
• Association between corticosteroid dosage and symptoms of depression and anxiety in patients with systemic lupus erythematosus (2025) · doi

  Some results showed wide confidence intervals (CIs), which could indicate instability in the model, especially for the anxiety variable, suggesting the need for further refinement of the model to improve accuracy and stability of estimates.

  Keywords: model wide confidence intervals indicate instability especially anxiety variable suggesting need further refinement improve accuracy
• Interaction between high-sensitivity C-reactive protein and mean platelet volume for 1-year major adverse cardiovascular events in stable coronary artery disease (2026) · doi

  Interaction estimates may be unstable with wide confidence intervals in the setting of few events; therefore, findings regarding interaction should be interpreted cautiously and warrant external validation.

  Keywords: interaction estimates unstable wide confidence intervals setting events regarding interpreted cautiously warrant external validation
• Machine Learning Prediction of Prevertebral Soft Tissue Swelling after Single-Level Anterior Cervical Surgery : A Proof-of-Concept Study (2026) · doi

  Several metrics are limited by wide confidence intervals, possibly due to limited sample size.

  Keywords: limited several metrics wide confidence intervals possibly sample size