Background Exercise alters intestinal microbiota composition; however, it remains unclear whether these alterations induced by long-term endurance exercise can be transferred by fecal microbiota trans

The gap

Consensus across the literature

Supporting evidence — 4 representative gaps

• Long-term endurance exercise influences exercise capacity in mice through modulation of the intestinal microbiota by fecal microbiota transplantation (2026) · doi

  Background Exercise alters intestinal microbiota composition; however, it remains unclear whether these alterations induced by long-term endurance exercise can be transferred by fecal microbiota transplantation (FMT) to improve recipient exercise capacity.

  Keywords: exercise microbiota background alters intestinal composition remains unclear whether alterations induced long term endurance transferred
• Reconsidering Obesity in India Through a Gut–Metabolic Lens: Mechanistic Insights and the Emerging Role of Synbiotics in Individuals with the Thin–Fat Phenotype (2026) · doi

  Despite growing enthusiasm, several challenges must be addressed before synbiotics can be fully integrated into obesity management frame- works. First, strain specificity is critical. Not all probiotics exert metabolic effects, and benefits depend on precise strain selection, dosing, and formulation. Second, interindividual variability in baseline microbiome composition influences responsiveness, necessitating personalized—or stratified—approaches. Third, most available studies are short-term, and long-term data on weight maintenance, durability of glycemic improvements, and cardiovascular outcomes remain limited. Regulatory standardization, quality control, and transparent reporting of microbial content and viability remain essential to ensure repro- ducibility and credibility. Importantly, micro- biome-modulating interventions should not be

  Keywords: strain term remain despite growing enthusiasm several challenges must addressed synbiotics fully integrated obesity management
• Exploring the probiotic landscape in understanding postbiotics from indigenous bacteria isolated from the stool samples of a tribal population at Mulluvadi village, Tamil Nadu, India (2026) · doi

  The present study is primarily limited by its exclusively in vitro the absence of comprehensive metabolomic design and characterisation of the postbiotic compounds. The SCFA detection in this work was of a preliminary nature and not fully validated quantitatively. Additionally, the taxonomic identification based on 16S rRNA gene sequencing may not provide strain-level resolution. The potential influences of age-related variability on the composition of the gut microbiome were not specifically controlled and represent another limitation of this study. Future studies involving whole-genome sequencing, metabolomic profiling, and in vivo validations are therefore necessary to confirm the functional and therapeutic potential of the identified isolates. Notwithstanding these limitations, our study offers important preliminary insights into the functional potential of probiotic isolates derived from a traditionally underexplored population. The integration of culture- based isolation with multi-parameter functional screening provides a useful framework for identifying candidate strains with desirable properties. From a translational perspective, such strains may serve the development of postbiotic-based as a formulations or next-generation probiotics pending rigorous validation. foundation for

  Keywords: based potential functional metabolomic postbiotic preliminary sequencing isolates strains present primarily limited exclusively vitro absence
• Gut-muscle axis (2026) · doi

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  Keywords: https microbiota exercise systematic review performance nutrients sport nutr athletic composition probiotics physical individuals athletes