CONCLUSIONS: Together, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still

The gap

Consensus across the literature

Supporting evidence — 3 representative gaps

• Mesolimbic and mesocortical pathways differentially support fentanyl-context associations (2026) · doi

  The ventral tegmental area (VTA) projects to both the nucleus accumbens (NAc) and prefrontal cortex (PFC), forming distinct pathways that are implicated in drug-cue associations, though their specific roles in fentanyl-context encoding are not well defined.

  Keywords: ventral tegmental area projects nucleus accumbens prefrontal cortex forming distinct pathways implicated drug associations though
• Genetic influences on the dynamics of pain and affect in fibromyalgia. (2010) · doi

  CONCLUSIONS: Together, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.

  Keywords: conclusions together offer researchers ample reason further investigate contribution catecholamine opioid systems associated genomic variants
• Uncovering phenotypic diversity and cell-type-specific prefrontal cortex calcium dynamics in rat fentanyl self-administration (2026) · doi

  BACKGROUNDThe proliferation of the potent synthetic opioid fentanyl has exacerbated the ongoing crisis of substance use disorder and associated overdose deaths, yet the neurobiological mechanisms that underlie individual vulnerability to addiction and relapse remain poorly understood, particularly in the context of fentanyl use.

  Keywords: fentanyl backgroundthe proliferation potent synthetic opioid exacerbated ongoing crisis substance disorder associated overdose deaths neurobiological