However, the evidence remains limited to observational studies; therefore, protocol standardization and controlled clinical trials are required to increase the level of evidence and allow this sequent

The gap

Consensus across the literature

Supporting evidence — 3 representative gaps

• Botulinum toxin type A and progressive pneumoperitoneum for loss-of-domain hernia: a narrative review (2026) · doi

  However, the evidence remains limited to observational studies; therefore, protocol standardization and controlled clinical trials are required to increase the level of evidence and allow this sequential therapeutic method to become a standard of care in routine clinical practice.

  Keywords: evidence clinical remains limited observational protocol standardization controlled trials required increase level allow sequential therapeutic
• The Utility and Validity of Current Diagnostic Procedures for Defining Temporomandibular Disorder Patients (1993) · doi

  The presented view is that many of these procedures have not been validated, that there is a lack of standardization in the use of the procedures themselves, and that an ideal method of classifying this broad group of patients into better-defined subgroups has not yet been developed.

  Keywords: procedures presented view validated there lack standardization themselves ideal classifying broad group patients better defined
• Ethanol Infusion into the Vein of Marshall Enhances Mitral Isthmus Block and Reduces Atrial Fibrillation Recurrence: A Comprehensive Meta-Analysis (2026) · doi

  Therefore, interpretation of the present findings should remain cautious, and future investigations should focus on defining clear patient selection strategies and procedural standardization to ensure consistent outcomes. It is also important to acknowledge that the current evidence base is limited by the 180 lack of standardized criteria for patient selection and variations in procedural techniques among studies.

  Keywords: patient selection procedural interpretation present remain cautious future investigations focus defining clear strategies standardization ensure