The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its

The gap

Consensus across the literature

Supporting evidence — 4 representative gaps

• Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment (2023) · doi

  The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.

  Keywords: tumor pdac microenvironment pancreatic ductal adenocarcinoma complex ecosystem drives progression depth single cell characterization role
• Diabetes-Driven Post-Translational Remodeling in Pancreatic Ductal Adenocarcinoma (2026) · doi

  Diabetes mellitus (DM), particularly Type 2 DM (T2DM), is increasingly recognized as both a risk factor and an early manifestation of pancreatic ductal adenocarcinoma (PDAC), yet the molecular mechanisms bridging these conditions remain poorly understood.

  Keywords: diabetes mellitus particularly type increasingly recognized risk factor early manifestation pancreatic ductal adenocarcinoma pdac molecular
• CXCL12 ⁺ pericytes as drivers of lymphatic dissemination in pancreatic cancer: Integrated single-cell and spatial analysis. (2026) · doi

  4126 Background: Pancreatic ductal adenocarcinoma (PDAC) exhibits poor prognosis largely due to early lymph node metastasis, yet the cellular and molecular mechanisms governing lymphatic dissemination remain incompletely understood.

  Keywords: background pancreatic ductal adenocarcinoma pdac exhibits poor prognosis largely early lymph node metastasis cellular molecular
• Cancer stem cells and mesenchymal stem cells in pancreatic ductal adenocarcinoma (2019) · doi

  Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and chemotherapy resistant cancer, in the development of which poorly studied cancer stem cells (CSC) and mesenchymal stem cells (MSC) are of great importance.

  Keywords: cancer stem cells pancreatic ductal adenocarcinoma pdac aggressive types chemotherapy resistant development poorly studied mesenchymal