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Agricultural and Biological Sciences · Research topic

Open research questions in Medicinal Plant Research

48 unresolved questions extracted from the limitations and future-work sections of 527 Medicinal Plant Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Oxidative stress is a major cause of non-communicable diseases. There is a need for natural antioxidants with reduced side effects. The study faced limitations in evaluating the antioxidant activity and analyzing individual flavonoid compounds.

    Analysis of Antioxidants and Flavonoid Compounds of Ethanol Extract of Starfruit Leaves (Averrhoa Bilimbi L) Using the DPPH Method · 2026 · DOI

  • The identification of potential therapeutic targets for idiopathic intestinal inflammation. The development of effective treatments for the disease. The need for further research to develop potentially curative pharmacotherapy.

    Potenciální terapeutické cíle v léčbě idiopatických střevních zánětů · 2026 · DOI

  • Vitamin D is sensitive to light, oxygen, and high temperatures. The study needed to develop a formulation that could stabilize vitamin D₂. The study needed to evaluate the physical properties and vitamin D₂ content of the capsules.

    FORMULASI DAN EVALUASI KAPSUL VITAMIN D2 DARI EKSTRAK ETANOL 96% JAMUR SAWIT (<i>Volvariella volvacea</i>) DENGAN MENGGUNAKAN METODE GRANULASI BASAH · 2026 · DOI

  • Further studies on the antioxidant activity of Illicium verum. Investigation of the potential use of Illicium verum in the treatment of chronic diseases.

    EKSPLORASI KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA LAWANG (ILLICIUM VERUM) · 2026 · DOI

  • Limited information on the phytochemical content and antioxidant activity of Illicium verum.

    EKSPLORASI KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA LAWANG (ILLICIUM VERUM) · 2026 · DOI

  • The ointment formulation uses only three extract concentrations (200, 400, 600 mg/kg BW); dose-response relationship across a wider range of concentrations requires investigation.

    Velvet bean (Mucuna pruriens L. (DC.)) leaf ointment: candidate for standardized natural anti-inflammatory drug ingredients based on local wisdom · 2026 · DOI

  • The study is based on an in silico approach and requires further experimental validation. The study only analyzes the potential of phytochemical compounds against the VP1 protein of Rhinovirus 2R06.

    Analisis Docking Molekuler Senyawa Fitokimia Indonesia terhadap Protein Rhinovirus 2R06 · 2026 · DOI

  • Further experimental validation is required to confirm the effectiveness and biological mechanisms of phytochemical compounds. The development of plant-based therapeutic candidates could be a future research direction.

    Analisis Docking Molekuler Senyawa Fitokimia Indonesia terhadap Protein Rhinovirus 2R06 · 2026 · DOI

  • Penelitian lebih lanjut diperlukan untuk mengetahui mekanisme efek nefroprotektif ekstrak bunga telang. Penelitian pada manusia diperlukan untuk mengkonfirmasi hasil penelitian ini.

    Efek Nefroprotektif Ekstrak Bunga Telang (Clitoria ternatea L.) Pada Tikus Model Nefrotoksisitas: Analisis Biokimia, Histopatologi, Antioksidan, dan Sitokin · 2026 · DOI

  • There is a need for alternative natural ingredients for oral health. There is a lack of knowledge on the antibacterial activity of cinnamon bark extract against Streptococcus mutans bacteria.

    Aktivitas Antibakteri Ekstrak Kulit Kayu Manis (Cinnamomum burmannii) terhadap Bakteri Streptococcus Mutans · 2026 · DOI

  • There is a lack of studies on the antioxidant activity and total flavonoid content of starfruit leaves extract. The study aims to fill this gap by evaluating the antioxidant activity and total flavonoid content of the extract.

    Analysis of Antioxidants and Flavonoid Compounds of Ethanol Extract of Starfruit Leaves (Averrhoa Bilimbi L) Using the DPPH Method · 2026 · DOI

  • The study found that further stability improvement is required. The cycling test showed changes in viscosity, spreadability, and adhesiveness. The study did not investigate the long-term stability of the serum.

    Optimization of Green Tea Leaf Extract Serum Using Xanthan Gum and Carbopol · 2026 · DOI

  • There is a need to optimize the combination of xanthan gum and carbopol in green tea leaf ethanol extract serum. There is a lack of studies on the physical stability of green tea extract serum formulations.

    Optimization of Green Tea Leaf Extract Serum Using Xanthan Gum and Carbopol · 2026 · DOI

  • Penelitian lebih lanjut tentang efek ekstrak kental daun jambu air pada manusia. Penelitian tentang kombinasi ekstrak kental daun jambu air dengan obat lain untuk pengobatan hipertensi.

    Standarisasi Ekstrak Daun Jambu Air sebagai Bahan Baku Obat Herbal Terstandar pada Pengobatan Hipertensi · 2026 · DOI

  • Kurangnya penelitian tentang ekstrak kental daun jambu air sebagai bahan baku obat herbal terstandar. Kurangnya informasi tentang aktivitas diuretik ekstrak kental daun jambu air.

    Standarisasi Ekstrak Daun Jambu Air sebagai Bahan Baku Obat Herbal Terstandar pada Pengobatan Hipertensi · 2026 · DOI

  • There is a lack of scientific data regarding the safety of Gedi leaf decoction, particularly its effects on liver and kidney function. The study aims to address this gap by evaluating the effects of fresh Gedi leaf decoction on liver and kidney function in female white rats.

    EVALUATION OF THE EFFECTS OF FRESH GEDI LEAF (ABELMOSCHUS MANIHOT (L.) MEDIK.) DECOCTION ON LIVER AND KIDNEY FUNCTION IN FEMALE WHITE RATS (RATTUS NORVEGICUS) · 2026 · DOI

  • The study had a limited sample size. The follow-up period was relatively short. The study did not investigate the combination of amivantamab and lazertinib in other types of cancer.

    Amivantamabo ir lazertinibo derinys – pirmos eilės terapija pažengusiam, EGFR geno mutacijomis pasižyminčiu nesmulkiųjų ląstelių plaučių vėžiui gydyti · 2026 · DOI

  • There is a need for new and effective treatments for NSCLC with EGFR gene mutations. Previous treatments have limitations, including the development of resistance.

    Amivantamabo ir lazertinibo derinys – pirmos eilės terapija pažengusiam, EGFR geno mutacijomis pasižyminčiu nesmulkiųjų ląstelių plaučių vėžiui gydyti · 2026 · DOI

  • Further studies can investigate the stability and toxicity of Kelakai root extract. Future research can explore the development of natural skincare products using Kelakai root extract.

    Antioxidant Activity and Sun Protection Factor (SPF) of Various Fractions of Ethanol Extract of Kelakai Roots (Stenochlaena palustris Bedd) · 2026 · DOI

  • There is a need for natural photoprotective agents that can prevent direct UV exposure and neutralize free radicals. Prior studies have not investigated the antioxidant and SPF properties of Kelakai root extract.

    Antioxidant Activity and Sun Protection Factor (SPF) of Various Fractions of Ethanol Extract of Kelakai Roots (Stenochlaena palustris Bedd) · 2026 · DOI

  • The study identifies a gap in the understanding of the effectiveness of ethanol extract from sea pandan on hydroxyproline levels in wound healing in male rats. The study highlights the need for further research on the optimal concentration of sea pandan ethanol extract gel for wound healing.

    Effectiveness of Ethanol Extract From Sea Pandan (Pandanus Tectorius) on Hydroxyproline Levels as A Parameter For Collagen Formation in The Healing Process of Incision Wounds in Male Rattus Norvegicus · 2026 · DOI

  • Therefore, further research is needed with a larger sample size, assessment at several points in time, and variations of several concentrations of sea pandan fruit extract to find out other concentrations that are more optimal and safe. In addition, the results of the study were limited to the incision wound model with the use of Bioplacenton® as the only positive control.

    Effectiveness of Ethanol Extract From Sea Pandan (Pandanus Tectorius) on Hydroxyproline Levels as A Parameter For Collagen Formation in The Healing Process of Incision Wounds in Male Rattus Norvegicus · 2026 · DOI

  • The mechanisms of interactions between herbal preparations and anesthetic drugs are not well understood. There is a need for further research on the interactions between herbal preparations and anesthetic drugs.

    Herbal Preparations Interactions with Drugs Used in Anesthesiological Practice · 2026 · DOI

  • The need for a comprehensive understanding of microbiome-pharmacotherapy interactions. The lack of personalized medicine approaches based on microbiome analysis.

    The microbiome and pharmacotherapy: from mechanisms to consequences · 2026 · DOI

  • The interactions between ARTA drugs and anticoagulants are not fully understood. There is a need for individualized management of these interactions.

    Interactions between ARTA drugs and orally administered anticoagulants · 2026 · DOI

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48 open questions have been extracted from the limitations and future-work passages of 527 Medicinal Plant Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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