Derived from large-scale data analyses (18)

The gap

Evidence profile

Stated in the limitations and recommendations and discussion and cells limitations sections of the source papers, classified as general, drawn from work published between 2024 and 2026, spanning 6 journals.

Supporting evidence — 8 representative gaps

• Comparison of Four Different Block Techniques for Postoperative Analgesia in Thoracotomy (2024) · Journal Of Cardıo-Vascular-Thoracıc Anaesthesıa And Intensıve Care Socıety · doi

  Our study had several limitations. First, it was a single- center study with a limited sample size, enrolling only 100 patients. Secondly, the analgesic effect was evaluated using a subjective indicator, as there was no objective indicator measuring the pain index. Third, some of the patients continued to experience pain for a long time after the operation. Therefore, the patients needed to be followed up for a longer period of time. However, this could help us better evaluate and compare the analgesic effects.

  generalstated in limitationsevidence 5/5
  Keywords: patients analgesic indicator pain time several limitations first single center limited sample size enrolling secondly
• Ultrasound-Guided Peripheral Nerve Block as the Sole Anesthetic for Above-Knee Amputation in a Patient With Severe Cardiopulmonary Comorbidities (2026) · Cureus · doi

  The principal limitations of this report are its single-case design and the clinical rather than dermatomal assessment of block completeness. Postoperative analgesia required repeat block performance on day 1 as single-injection coverage resolved; prospective consideration of perineural catheter placement for continuous local anesthetic infusion may provide more durable analgesia in future cases of comparable complexity.

  generalstated in limitationsevidence 5/5
  Keywords: single block analgesia principal limitations report case design clinical rather dermatomal assessment completeness postoperative required
• Effectiveness of Kinesio Taping and Proper Body Mechanics on Low Back Pain in Pregnancy (2026) · Jurnal Manajemen Informasi Kesehatan (Health Information Management) · doi

  The limitations of this study its quasi-experimental design without full randomization, which may have introduced selection bias. In addition, the study was conducted within a single healthcare service area, which limits the generalizability of the findings. Pain assessment relied on self-reported NRS scores, which may be influenced by subjective perception. The intervention duration was short-term, so long-term effects were not assessed.

  generalstated in limitationsevidence 5/5
  Keywords: term limitations quasi experimental design without full randomization introduced selection bias addition conducted within single
• Effectiveness of Kinesio Taping and Proper Body Mechanics on Low Back Pain in Pregnancy (2026) · Jurnal Manajemen Informasi Kesehatan (Health Information Management) · doi

  its quasi-experimental design without full randomization, which may have introduced selection bias. In addition, the study was conducted within a single healthcare service area, which limits the generalizability of the findings. Pain assessment relied on self-reported NRS scores, which may be influenced by subjective perception. The intervention duration was short-term, so long-term effects were not assessed.

  generalstated in limitationsevidence 5/5
  Keywords: term quasi experimental design without full randomization introduced selection bias addition conducted within single healthcare
• Postoperative Pain Assessment: Emerging Technologies and Clinical Implications (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi

  derived from large-scale data analyses (18). Collectively, these technological advancements not only improve the effectiveness of pain management and the efficiency of clinical processes but also enhance patients’ treatment experiences and quality of life, supporting the emergence of personalized, technology-driven next-generation pain management paradigms.

  generalstated in recommendationsevidence 5/5
  Keywords: pain management treatment derived large scale analyses collectively technological advancements improve effectiveness efficiency clinical processes
• Chronic postoperative inguinal pain after open inguinal hernioplasty: prevalence and clinical characteristics in a Mexican secondary care hospital (2026) · International Surgery Journal · doi

  Despite these limitations, this study provides valuable local epidemiological data regarding chronic postoperative inguinal pain in a Mexican secondary care setting, an area in which published evidence remains limited. Future multicenter studies with larger sample sizes and longer follow-up periods are warranted to better characterize risk factors associated with chronic postoperative inguinal pain and to evaluate strategies aimed at preventing this complication.

  generalstated in discussionevidence 5/5
  Keywords: chronic postoperative inguinal pain despite limitations provides valuable local epidemiological regarding mexican secondary care setting
• Factors influencing optimal postoperative pain management: a systematic scoping review (2026) · Frontiers in Pain Research · doi

  On the other hand, limited knowledge and misconceptions about pain, fear and negative perceptions of pain medication, expression challenges, individual and contextual limitations, knowledge and competency and collaboration challenges, professional constraints, organizational and policy deficiencies, resource and workforce constraints, and care coordination and continuity challenges, were key barriers to optimal postoperative pain management.

  generalstated in discussionevidence 5/5
  Keywords: pain challenges knowledge constraints hand limited misconceptions fear negative perceptions medication expression individual contextual limitations
• Factors influencing optimal postoperative pain management: a systematic scoping review (2026) · Frontiers in Pain Research · doi

  The review is limited by the quality and availability of the existing literature on postoperative pain management. - The review may be subject to biases in the included studies, including publication bias and selective reporting. - The review does not provide a quantitative synthesis of the included studies, limiting the ability to draw definitive conclusions about the effectiveness of specific interventions.

  generalstated in cells limitationsevidence 5/5
  Keywords: review limited quality availability existing literature postoperative pain

Questions about this gap