Further exploration of the green synthesis method
Research gap analysis derived from 5 chemistry papers in our local library.
The gap
Further exploration of the green synthesis method for mixed ligand metal complexes. Investigation of the potential for mixed ligand metal complexes as antimicrobial agents in various applications.
Evidence profile
Sourced from the future-work section and inline gaps and abstract of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 5 journals. Those papers have been cited 5 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 5 representative gaps
- Fe(II), Cu(II), Ni(II) and Co(II) metal complexes of sulfonamide ligand derived from sulfadiazine: synthesis, characterization, cytotoxic activity and DNA/BSA binding properties (2026) · Journal of the Iranian Chemical Society · doi
To study the in vivo activity of the ligand and its metal complexes. To study the toxicity of the ligand and its metal complexes. To develop new drugs for cancer treatment using the ligand and its metal complexes.
generalfuture-work sectionevidence 5/5Keywords: study vivo activity ligand metal complexes toxicity develop - Green Synthesis and Biological Evaluation of Mixed Ligand Metal Complexes for Enhanced Antimicrobial Potential (2026) · Modern Dynamics Journal of Chemistry (MDJC) · doi
Further exploration of the green synthesis method for mixed ligand metal complexes. Investigation of the potential for mixed ligand metal complexes as antimicrobial agents in various applications.
generalfuture-work sectionevidence 5/5Keywords: further exploration green synthesis method mixed ligand metal - Synthesis and Biological Screening of Novel Pyrazole-Based Isoxazoline Derivatives as Antibacterial and Antioxidant Agents (2026) · International Journal of Drug Delivery Technology · doi
Future investigations may focus on molecular in vivo docking studies, pharmacological structural optimization these compounds as potential therapeutic candidates for infectious and oxidative stress-related diseases.
generalinline gapsevidence 4/5Keywords: future investigations focus molecular vivo docking pharmacological structural optimization compounds potential therapeutic candidates infectious oxidative - Synthesis, characterization, and antibacterial activity of Ni(II) complex bearing salen ligand (2025) · Pharmacia · cited 5× · doi
The findings demonstrate that metal complexation significantly improves antimicrobial potency compared to the free ligand and support further investigation of these compounds for pharmaceutical and industrial antimicrobial applications.
generalabstractevidence 4/5Keywords: antimicrobial demonstrate metal complexation improves potency compared free ligand support further investigation compounds pharmaceutical industrial - Synthesis, Spectroscopic Characterization, Antioxidant Activity, and Molecular Docking Studies of Novel Ceftiofur-Based Metal Complexes (2026) · Journal of the Turkish Chemical Society Section A Chemistry · doi
Further studies are needed to fully elucidate the biological activity of the synthesized metal complexes. The potential toxicity of the synthesized metal complexes should be evaluated. The use of molecular docking simulations can be explored further in the development of new antimicrobial drugs.
generalfuture-work sectionevidence 3/5Keywords: further studies needed fully elucidate biological activity synthesized
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