The relationship between frailty and cognition in different populations

The gap

Evidence profile

Sourced from the future work and inline gaps and future-work section and stated research gap of the source papers, classified as general, spanning 3 journals. Those papers have been cited 2 times in total.

Supporting evidence — 4 representative gaps

• Gender differences in the association between physical frailty and cognitive function among older adults: A cross-sectional study in rural Guizhou, China (2026) · Scientific Reports · doi

  should incorporate multi-domain neuropsychological batteries, alongside imaging and biomarker approaches, to provide a more granular characterization of cognitive function. Despite these limitations, the present study offers preliminary evidence that may inform future sex-specific, precision-oriented interventions. In conclusion, there exist gender differences in the relationship between physical frailty and cognitive function in rural China, with women showing a stronger association. The results indicate that women's cognitive function is more vulnerable to the effects of frailty; however, future prospective studies are needed to confirm this conclusion. Y.H., J.T., and J.Y. conceived the study and analyzed the data. J.T. and H.Q. conducted the experiments and performed sample collection. Y.H. and W.L. wrote the manuscript. J.Y. and W.L. designed the project and acquired funding. All authors reviewed and approved the manuscript. All authors ensure the accuracy and integrity of all aspects of the work.

  generalfuture work
  Keywords: cognitive function future conclusion frailty women manuscript authors incorporate multi domain neuropsychological batteries alongside imaging
• Long-Term Flywheel Resistance Training Enhances Cognitive Flexibility in Older Women: A 36-Week Randomized Controlled Trial (2026) · Journal of Functional Morphology and Kinesiology · doi

  The exclusive inclusion of community-dwelling older women limits generalizability to men, younger adults, or clinical populations such as those with mild cognitive impairment or dementia, and whether the observed superiority of FRT for cognitive flexibility would be replicated in other groups remains unclear.

  generalinline gaps
  Keywords: cognitive exclusive inclusion community dwelling older women limits generalizability younger adults clinical populations mild impairment
• Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction (2026) · Frontiers in Aging Neuroscience · cited 1× · doi

  further studies are needed to investigate the relationship between frailty and cognition in different populations, - longitudinal studies are needed to examine the temporal relationship between frailty and CI, - research on modifiable lifestyle factors and their impact on post-stroke cognitive vulnerability is needed

  generalfuture-work sectionevidence 5/5
  Keywords: further studies needed investigate relationship between frailty cognition
• Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction (2026) · Frontiers in Aging Neuroscience · cited 1× · doi

  The interaction between frailty and cognition in elderly patients with acute cerebral infarction is not well understood. There is a lack of studies investigating the relationship between frailty and cognitive impairment in this population. Prior studies have not adequately addressed the impact of lifestyle factors on cognitive impairment after stroke.

  generalstated research gapevidence 4/5
  Keywords: interaction between frailty cognition elderly patients acute cerebral

Questions about this gap