Understand the molecular mechanisms underlying disease

The gap

Evidence profile

Sourced from the future-work section and future work of the source papers, classified as general, drawn from work published between 2024 and 2026, spanning 3 journals. Those papers have been cited 78 times in total.

Supporting evidence — 3 representative gaps

• Pathogenesis of Endometriosis and Endometriosis-Associated Cancers (2024) · International Journal of Molecular Sciences · cited 78× · doi

  further studies are needed to understand the molecular mechanisms underlying disease etiology, - the application of single-cell and spatial genomics, along with the development of organoid models, may illuminate the molecular mechanisms of endometriosis, - novel approaches and in vitro models may offer new avenues for improving our understanding of disease pathology and for developing new targeted therapies

  generalfuture-work section
  Keywords: further studies needed understand molecular mechanisms underlying disease
• Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management (2026) · Frontiers in Reproductive Health · doi

  Drug repurposing strategies Based on transcriptome-drug feature matching, alreadyapproved drugs such as genistein, pioglitazone, and alprostadil are predicted to improve endometrial function, although clinical validation is pending (39). 6.6.2 Induced pluripotent stem cells (iPSCs) Differentiation into oocyte-like cells has been achieved in animal models, but remains at the preclinical stage (105, 106). 6.6.3 Personalized treatment selection Individualization of endometrial preparation based on patient characteristics has been proposed as a strategy to optimize reproductive outcomes (107). Precision therapy based on dysbiotic, inflammatory, or mixed endometrial dysfunction) represents a future direction, although rapid point-of-care testing tools are currently lacking (42).

  generalfuture workevidence 5/5
  Keywords: endometrial based drug cells repurposing strategies transcriptome feature matching already approved drugs genistein pioglitazone alprostadil
• ENDOMETRIAL RECEPTIVITY: MOLECULAR MECHANISMS, THIN ENDOMETRIUM SUBTYPES, AND MECHANISM-BASED THERAPEUTIC APPROACHES (2026) · Kocaeli Üniversitesi Sağlık Bilimleri Dergisi · doi

  Advancing the field of endometrial receptivity requires a shift from morphology-based assessment toward molecularly defined, phenotype-oriented diagnostic frameworks. Future research should focus on identifying and validating standardized, clinically applicable molecular signatures capable of distinguishing functional from non-functional endometrium, independent of endometrial thickness. High-resolution single-cell approaches transcriptomics, spatial proteomics, and metabolomic profiling are expected to refine mechanistic subtyping and reveal actionable therapeutic targets. In parallel, well- designed prospective and multicenter clinical trials are needed to evaluate pathway-specific interventions, including regenerative, immune-targeted, and metabolic strategies, within clearly defined biological phenotypes.

  generalfuture workevidence 5/5
  Keywords: endometrial defined functional advancing field receptivity requires shift morphology based assessment toward molecularly phenotype oriented

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