Further understanding of how genetic risk and environmental stressors inter-relate in the etiology of MD and AUD

The gap

Evidence profile

Sourced from the future work and inline gaps and future-work section of the source papers, classified as general, drawn from work published between 1986 and 2026, spanning 5 journals. Those papers have been cited 12 times in total.

Supporting evidence — 6 representative gaps

• The dual structure of anxiety: reconciling general and specific approaches (2026) · Frontiers in Psychology · doi

  and interactions should examine multiple domain-specific anxieties alongside trait anxiety using longitudinal designs the to track their development lifespan. Studies of brain dynamics could clarify whether different anxiety domains share underlying neural networks. Methodologically, there is a clear need for an integrative tool that assesses both trait and specific anxiety simultaneously. between

  generalfuture work
  Keywords: anxiety speci trait interactions examine multiple domain anxieties alongside using longitudinal designs track development lifespan
• Heritability of generalized anxiety stability: a longitudinal twin study among young adults (2025) · Psychological Medicine · cited 1× · doi

  The current findings suggest that extracting temporal stability of anxiety could substantially increase power for genomic studies of anxiety. In addition, we found that environmental factors have persistent effects on generalized anxiety in young adulthood, which has implications for investigating how environmental risks shape anxiety during this period. Exploring whether putative environ- mental risk factors have short- or long-term effects or differentially impact symptom dimensions could bring new insights into the etiology of generalized anxiety in young adulthood and ultimately inform treatment development. Supplementary material. The supplementary material for this article can be found at http://doi.org/10.1017/S0033291725100640. Acknowledgments. We gratefully acknowledge the ongoing contribution of the participants in the Twins Early Development Study (TEDS) and their families. TEDS is supported by the UK Medical Research Council (MR/V012878/1 and previously MR/M021475/1). This study presents independent research part- funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author and not necessarily those of the NHS, the NIHR, or the Department of Health. G.M.-V. was supported by a postdoctoral fellowship from the Social Sciences and Humanities Research Council of Canada (756-2021-0516) and Fonds de recherche du Quebec Societe et Culture (2022-B3Z-297753). J.F. was supported by a PhD fellowship from the Studienstiftung des deutschen Volkes. Competing interests. The authors have no conflict of interest to disclose.

  generalfuture work
  Keywords: anxiety supported found environmental factors effects generalized young adulthood development supplementary material teds council health
• Anxiety and Problem-solving Ability in Mothers of Premature Infants (1986) · Journal of Obstetric, Gynecologic & Neonatal Nursing · cited 9× · doi

  Further research is needed to determine if the lack of a relationship between anxiety and previous adverse pregnancy outcome can be gener- alized to all mothers of premature infants in neonatal intensive care units. Certainly this descriptive study is limited both by the fact that no attempt was made to control for intervening variables such as age or parity that might have influ- enced anxiety and problem-solving ability scores and by the fact that no data were obtained on mothers before the birth of their premature infants.

  generalinline gaps
  Keywords: anxiety mothers premature infants fact further needed determine lack relationship previous adverse pregnancy outcome gener
• The joint effects of genetic liability and the death of close relatives on risk for major depression and alcohol use disorder in a Swedish national sample (2024) · Psychological Medicine · cited 2× · doi

  Further understanding of how genetic risk and environmental stressors inter-relate in the etiology of MD and AUD, - Examination of the association between stressful life events and risk for episode onset or recurrence of a range of psychiatric disorders, - Investigation of the molecular genetic data

  generalfuture-work sectionevidence 5/5
  Keywords: further understanding genetic risk environmental stressors inter-relate etiology
• RDoC-informed research on the anxiety disorders: best practices and future directions (2026) · The British Journal of Psychiatry · doi

  examining interactions between biobehavioural dysfunctions, environmental factors and developmental trajectories, - incorporating environmental and developmental factors into research questions, - adopting dimensional approaches when investigating mechanisms associated with specific types of anxiety, - using multidimensional approaches to examine mechanisms in relation to multiple clinical spectra

  generalfuture-work sectionevidence 5/5
  Keywords: examining interactions between biobehavioural dysfunctions environmental factors developmental
• Parental Threats and Anxiety Severity in Trauma-Exposed Adolescents: The Role of Anxiety Sensitivity (2026) · Journal of Child & Adolescent Trauma · doi

  Further research is needed to explore the facets of anxiety sensitivity in the association between parental threatening behaviors and anxiety symptom severity - Longitudinal studies could examine the developmental trajectory of anxiety sensitivity and its relationship to parental threatening behaviors

  generalfuture-work sectionevidence 5/5
  Keywords: further research needed explore facets anxiety sensitivity association

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