Increasing evidence suggests that the tumor immune

The gap

Evidence profile

Sourced from the limitations section and abstract and stated challenges of the source papers, classified as general, spanning 4 journals.

Supporting evidence — 4 representative gaps

• CD200–CD200R as a myeloid immune checkpoint in solid tumors: mechanisms, context-dependent functions, and therapeutic opportunities (2026) · Frontiers in Immunology · doi

  Most patients either fail to respond or eventually develop disease progression to current immune checkpoint blockade therapies, - Direct functional studies of CD200-CD200R signaling in the NSCLC tumor microenvironment remain limited, - Tissue-based CD200/CD200R assessment alone may not fully capture pathway activity that is relevant to therapeutic responses

  generallimitations section
  Keywords: patients either fail respond eventually develop disease progression
• IFI44L modulates chemoradiotherapy sensitivity and CD8+ T cell infiltration in colorectal cancer (2026) · Frontiers in Oncology · doi

  Increasing evidence suggests that the tumor immune microenvironment (TME) especially intratumoral CD8 + T cells plays an important role in determining CRT efficacy; however, the molecular mechanisms linking tumor-derived factors to immune-mediated treatment sensitivity remain poorly understood.

  generalabstractevidence 5/5
  Keywords: tumor immune increasing evidence suggests microenvironment especially intratumoral cells plays important role determining efficacy molecular
• FOXP1 transcriptionally activates NUSAP1 to induce M2 polarization of tumor-associated macrophages via glycolysis in hepatocellular carcinoma (2026) · Frontiers in Genetics · doi

  High HCC mortality is closely linked to high metastasis rates and therapy resistance, largely due to the immunosuppressive state of the tumor microenvironment. The complex interactions between tumor cells, immune cells, and the microenvironment pose a significant challenge to understanding HCC progression. The development of effective therapeutic strategies for HCC is hindered by the limited understanding of the molecular mechanisms underlying the disease.

  generalstated challengesevidence 5/5
  Keywords: high hcc mortality closely linked metastasis rates therapy
• DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma (2026) · Cancers · doi

  Immune exclusion is a major resistance mechanism to immunotherapy in HNSCC. The complex interactions between malignant epithelial cells, cancer-associated fibroblasts (CAFs), and infiltrating immune cells in the tumor microenvironment (TME) pose a challenge to understanding the molecular programs driving immune exclusion. The limited durable responses to immune checkpoint inhibitors in HNSCC patients pose a challenge to the development of effective therapies.

  generalstated challengesevidence 5/5
  Keywords: immune exclusion major resistance mechanism immunotherapy hnscc complex

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