Intraoperative hypotension is common in noncardiac

The gap

Evidence profile

Sourced from the stated challenges and limitations and inline gaps of the source papers, classified as general, drawn from work published between 2024 and 2026, spanning 3 journals. Those papers have been cited 55 times in total.

Supporting evidence — 3 representative gaps

• Association of intraoperative hypotension and cumulative norepinephrine dose with postoperative acute kidney injury in patients having noncardiac surgery: a retrospective cohort analysis (2024) · British Journal of Anaesthesia · cited 55× · doi

  Intraoperative hypotension is common in noncardiac surgery patients and is associated with acute kidney injury. The use of vasopressors like norepinephrine is common, but their effects on acute kidney injury are unclear. The study requires careful consideration of confounding factors and the development of strategies to reduce the risk of postoperative acute kidney injury.

  generalstated challenges
  Keywords: intraoperative hypotension common noncardiac surgery patients associated acute
• Effect of vasopressor catecholamines on tissue perfusion and mortality in patients with septic shock in ICU (2026) · International Journal of Drug Delivery Technology · doi

  injury allowed independently associated with Third, the results support catecholamine-sparing strategies in patients with increasing doses of norepinephrine. Although vasopressin use was not lower mortality in this analysis, its higher use in the high-exposure group the common practice of adding nonadrenergic vasopressors in refractory shock. Future studies should assess whether earlier introduction of vasopressin reduces catecholaminergic load and improves tissue perfusion. 5.5. Strengths of the study A relevant strength is the integration of clinical, hemodynamic, and metabolic variables. Unlike studies focusing only on mortality or lactate, this lactate included vasopressor dose, analysis clearance, capillary refilling, diuresis, SOFA, and mortality. This approach better reflects the pathophysiological complexity of septic shock. Another strength is the multivariate analysis adjusted for basal gravity. The inclusion of APACHE II, SOFA, initial lactate, and acute kidney to partially reduce confounding by indication. In addition, the comparison of predictive models showed that the incorporation of vasopressor load and tissue perfusion improves mortality discrimination. 5.6.

  generallimitationsevidence 5/5
  Keywords: mortality lactate vasopressin shock load improves tissue perfusion strength vasopressor sofa injury allowed independently associated
• Hemodynamic Impact of Vasopressor Therapy in Critically Ill Patients with Septic Shock in the Intensive Care Unit (2026) · IECCMEXICO · doi

  Future research should focus on personalized hemodynamic management, advanced monitoring technologies, and precision-based therapeutic approaches capable of further improving survival, reducing organ dysfunction, and enhancing the quality of critical care delivered to patients with septic shock throughout the American continent. Nevertheless, further research is required to clarify its long-term effects on survival and organ function. Although additional research is needed to further clarify their long-term impact on survival and organ preservation, these agents represent important therapeutic options that may enhance individualized hemodynamic management. Although evidence regarding mortality benefits remains inconclusive, vasopressin may reduce catecholamine exposure and contribute to improved vascular responsiveness through alternative physiological pathways (Russell et al.

  generalinline gapsevidence 5/5
  Keywords: further survival organ hemodynamic management therapeutic clarify long term future focus personalized advanced monitoring technologies

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