Investigating the combination of different natural bioactive compounds

The gap

Evidence profile

Sourced from the stated research gap and future-work section of the source papers, classified as general, drawn from work published between 2024 and 2026, spanning 4 journals. Those papers have been cited 62 times in total.

Supporting evidence — 6 representative gaps

• Antimicrobial activity of an ellagic acid-incorporated iron oxide nanocomposite hydrogel derived from herbal formulations against wound pathogens (2026) · Plant Science Today · doi

  Current treatments for wound infections have limitations, including toxicity and limited efficacy. There is a need for novel antimicrobial materials with high efficacy and low toxicity. Herbal formulations have been shown to have antimicrobial properties, but their efficacy is limited.

  generalstated research gapevidence 5/5
  Keywords: current treatments wound infections have limitations including toxicity
• Study on Berberine/Glycyrrhizic Acid Monoammonium Salt Self-Assembled Hydrogel for Diabetic Wound Healing (2026) · Gels · doi

  Current dressings fail to relieve all pathological defects of diabetic wounds simultaneously. Most reported berberine-loaded wound dressings rely on exogenous polymer matrices for drug encapsulation, which may bring potential biocompatibility risks and burst drug release.

  generalstated research gapevidence 5/5
  Keywords: current dressings fail relieve all pathological defects diabetic
• Biobased composite fibrous membrane using PLA and lignin carbon dots fabricated via solution blow spinning for wound dressing application (2024) · Materials Today Communications · cited 9× · doi

  There is a need for improved wound dressings that can promote faster healing and reduce the risk of infection. Current wound dressings have limitations, including lack of antimicrobial activity and controlled release of therapeutic compounds. The paper identifies a gap in the development of multi-functional wound dressings that can combine conventional properties with advanced functions.

  generalstated research gapevidence 5/5
  Keywords: there need improved wound dressings promote faster healing
• Bacterial Cellulose-Based Superabsorbent Hydrogel for Wet Wound Dressing (2025) · Molecules · cited 20× · doi

  Current gel-based wound dressings have challenges such as the risk of bacterial infection. The need for a dressing that can maintain a moist environment on the surface of the wound and prevent excessive saturation of exudates. The lack of a suitable hydrogel with medium permeability and high water absorption capacity.

  generalstated research gapevidence 5/5
  Keywords: current gel-based wound dressings have challenges risk bacterial
• Natural Bioactive Compound-Integrated Nanomaterials for Diabetic Wound Healing: Synergistic Effects, Multifunctional Designs, and Challenges (2025) · Molecules · cited 24× · doi

  Investigating the combination of different natural bioactive compounds, - Developing innovative nanoformulations to improve the delivery of natural bioactive compounds, - Exploring the potential of nanomaterials in regulating immunity and promoting wound healing

  generalfuture-work sectionevidence 5/5
  Keywords: investigating combination different natural bioactive compounds developing innovative
• Biobased composite fibrous membrane using PLA and lignin carbon dots fabricated via solution blow spinning for wound dressing application (2024) · Materials Today Communications · cited 9× · doi

  Further studies are needed to evaluate the in vivo performance of the developed wound dressings, - The effects of LCdots and Curcumin on wound healing processes should be investigated, - The scalability and cost-effectiveness of the solution blow spinning technique should be assessed

  generalfuture-work sectionevidence 3/5
  Keywords: further studies needed evaluate vivo performance developed wound

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