Investigation into the synergistic interactions between the core factors that influence the performance of elite endurance athletes

The gap

Evidence profile

Sourced from the recommendations and limitations section and future-work section of the source papers, classified as general, spanning 3 journals. Those papers have been cited 47 times in total.

Supporting evidence — 3 representative gaps

• Precision nutrition in sports science: an opinion on omics-based personalization and athletic outcomes (2025) · Frontiers in Nutrition · cited 12× · doi

  and 115. Bailey RL, Dog TL, Smith-Ryan AE, Das SK, Baker FC, Madak-Erdogan Z, et al. Sex differences across the life course: a focus on unique nutritional and health considerations among women. J Nutr. (2022) 152:1597–610. doi: 10.1093/jn/ nxac059 118. Jaguri A, Al Thani AA, Elrayess MA. Exercise metabolome: insights for health and performance. Metabolites. (2023) 13:694. doi: 10.3390/metabo13060694 119. Glass KA, Germain A, Huang YV, Hanson MR. Urine metabolomics exposes anomalous recovery after maximal exertion in female ME/CFS patients. Int J Mol Sci. (2023) 24:3685. doi: 10.3390/ijms24043685 120. Appel M, Zentgraf K, Krüger K, Alack K. Effects of genetic variation on endurance performance, muscle strength, and injury susceptibility in sports: a systematic review. Front Physiol. (2021) 12:694411. doi: 10.3389/fphys.2021.694411 121. Varillas-Delgado D, Del Coso J, Gutiérrez-Hellín J, Aguilar-Navarro M, Muñoz A, Maestro A, et al. Genetics and sports performance: the present and future in the identification of talent for sports based on DNA testing. Eur J Appl Physiol. (2022) 122:1811–30. doi: 10.1007/s00421-022-04945-z 122. Shang Z, Pai L, Patil S. Unveiling the dynamics of gut microbial interactions: a review of dietary impact and precision nutrition in gastrointestinal health. Front Nutr. (2024) 11:1395664. doi: 10.3389/fnut.2024.1395664 116. Ceylan H. Nutritional for fueling 8. doi: 10.61838/kman.hn.1.4.11 athletes’ optimal strategies and recovery. Health Nexus. for peak performance: guidelines 1:90– (2023) 123. Hayes CN, Nakahara H, Ono A, Tsuge M, Oka S. From omics (2024) advantages tradeoffs. Genes. review of and a to multi-omics: 15:1551. doi: 10.20944/preprints202411.0882.v1

  generalrecommendationsevidence 5/5
  Keywords: health performance sports review nutritional nutr recovery front physiol omics bailey smith ryan baker madak
• DXA-Measured Total and Regional Body Composition in Female Athletes with a Physical Impairment (2025) · Journal of Functional Morphology and Kinesiology · cited 4× · doi

  the relatively limited number of female athletes with a physical impairment in this study prevented the investigation of body composition according to the type of physical impairment - we were unable to assess the dietary habits and basal metabolism of the participants, which could have affected their body composition - we were unable to assess the participants' dietary habits, basal metabolism, or menstrual cycle, or the presence of menstrual dysfunctions, which could have affected their body composition

  generallimitations sectionevidence 5/5
  Keywords: relatively limited number female athletes physical impairment study
• A Review of Carbohydrate Supplementation Approaches and Strategies for Optimizing Performance in Elite Long-Distance Endurance (2025) · Nutrients · cited 31× · doi

  investigation into the synergistic interactions between the core factors that influence the performance of elite endurance athletes - study of the causal and dose-response relationships between factors, such as altitude, temperature, gastrointestinal function, and the menstrual cycle, and carbohydrate metabolism - development of predictive models for glycogen deficiency - further research into strategies, such as the 'sleep low, train low' approach and the 'glycogen threshold' hypothesis

  generalfuture-work sectionevidence 5/5
  Keywords: investigation synergistic interactions between core factors influence performance

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