No integrated pipeline exists for natural product-based antibiotic discovery that combines crude extract screening

The gap

Evidence profile

Sourced from the future work and synthesized of the source papers, classified as general, drawn from work published between 2023 and 2026, spanning 3 journals. Those papers have been cited 113 times in total.

Supporting evidence — 3 representative gaps

• Exploring the probiotic landscape in understanding postbiotics from indigenous bacteria isolated from the stool samples of a tribal population at Mulluvadi village, Tamil Nadu, India (2026) · Frontiers in Pharmacology · doi

  in the preparation of Additional research efforts should be directed toward extracting and solving the structures of the most important cellular metabolites, such as SCFAs, EPSs, and proteolytic enzymes, along with exploring their effects in appropriate animal models of inflammation, metabolic disorders, and gut microbiota imbalance. At the same time, changes in large-scale fermentation processes are indispensable for promoting their utilisation foods, nutraceuticals, or disease treatments. Moreover, clinical evaluations at identifying new biosynthetic gene clusters will be necessary before such tribal-derived microbial resources can be used as precision these therapeutics. considerations, our study provides a firm basis for the in next-generation efficient use of native microbiomes management of gut health. We suggest that future studies should focus on whole-genome sequencing of the selected strains, detailed metabolomic profiling of the postbiotic genome-resolved functional postbiotic studies aimed

  generalfuture work
  Keywords: genome postbiotic preparation additional efforts directed toward extracting solving structures important cellular metabolites scfas epss
• Microbiota, natural products, and human health: exploring interactions for therapeutic insights (2024) · Frontiers in Cellular and Infection Microbiology · cited 27× · doi

  Looking ahead, the field stands at the precipice of unprecedented discoveries and applications. Delving into the study of gut microbes and their role in the synthesis of bioactive compounds on a larger scale presents an exciting avenue for future research. The untapped potential of harnessing the therapeutic benefits of these interactions holds promise for innovative approaches to medicine and therapeutics. The multifaceted relationships between natural products and gut microbiota open new doors for drug discovery, as the microbiome becomes a potential source of novel compounds with therapeutic applications. Future research should focus on elucidating the specific mechanisms by which these microbiome-derived naturally occurring compounds exert their effects on the well-being of humans. This involves a deeper understanding of the metabolic pathways involved, the pharmacological activities of these compounds, and their potential applications in treating various diseases. Moreover, the development of technologies and methodologies for the systematic characterization of small molecules generated by human-associated microorganisms is crucial. Advancements in analytical techniques and high-throughput screening methods will facilitate the identification and isolation of novel microbiome- derived natural products. Collaborations between microbiologists, pharmacologists, and clinicians will be essential in translating these discoveries into practical applications. The integration of microbiome-based therapies into personalized medicine holds the potential to revolutionize healthcare, offering tailored treatments based on an individual’s unique microbiome profile. In a nutshell, the intersection of natural products, bacteria, and human health represents a frontier of scientific exploration with profound implications for medicine and therapeutics. As we navigate this Frontiers in Cellular and Infection Microbiology 13 frontiersin.org Qadri et al. 10.3389/fcimb.2024.1371312 FIGURE 5 Depicts diverse elements influencing gut microbiota modulation, encompassing lifestyle, age, medication, genetics, geography, and dietary factors. This comprehensive overview highlights the multifaceted nature of gut microbiota dynamics. By highlighting these intricate relationships, this visual representation enhances our understanding of the dynamic interplay between external influences and internal microbial ecosystems, ultimately informing personalized approaches to gut health management.” (Created with Biorender). dynamic field, the collaborative efforts of researchers across disciplines will be instrumental in unlocking the full potential of microbiome-derived natural products and ushering in a new era of innovative healthcare solutions.

  generalfuture work
  Keywords: microbiome potential applications compounds natural products medicine microbiota derived discoveries future therapeutic holds innovative approaches
• Applications of molecular docking in natural products-based drug discovery (2023) · Scientific African · cited 86× · doi

  No integrated pipeline exists for natural product-based antibiotic discovery that combines crude extract screening, active principle isolation, structure elucidation, and molecular docking-guided target validation. Current practice separates crude extract assays from pure compound characterization, and studies isolating secondary metabolites have limited bioactivity evaluations.

  generalsynthesizedevidence 5/5
  Keywords: integrated pipeline exists natural product-based antibiotic discovery combines

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