No study in this set prospectively compares
Research gap analysis derived from 3 medicine papers in our local library.
The gap
No study in this set prospectively compares the diagnostic accuracy of a combined ultrasound-Doppler-serum panel against liver biopsy (the reference standard) in a single tertiary-care cohort of adults with chronic hepatitis C. Prior valida
Evidence profile
Sourced from the synthesized of the source papers, classified as general, spanning 2 journals.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- Liver stiffness at baseline as a marker of hepatocellular carcinoma in cirrhosis: A matched analysis (2026) · World Journal of Gastrointestinal Pathophysiology · doi
Across this set, ultrasound-based fibrosis assessment is evaluated only in retrospective or cross-sectional designs (transient elastography in papers 3, 4, 5, 7, 11, 12) and in post-SVR or cirrhotic populations; no prospective validation of a multiparametric ultrasound-Doppler panel (combining B-mode, elastography, and Doppler flow parameters) exists in adults with active chronic hepatitis C prior to or independent of antiviral treatment response.
generalsynthesizedevidence 5/5Keywords: across set ultrasound-based fibrosis assessment evaluated only retrospective - Clinicopathological characteristics and risk factors in nonalcoholic steatohepatitis patients with different stages of liver fibrosis (2026) · World Journal of Hepatology · doi
No study in this set prospectively compares the diagnostic accuracy of a combined ultrasound-Doppler-serum panel against liver biopsy (the reference standard) in a single tertiary-care cohort of adults with chronic hepatitis C. Prior validation studies use either biopsy alone (paper 5, 6) or transient elastography without biopsy correlation (papers 3, 4, 7), and none integrate Doppler vascular parameters into the assessment.
generalsynthesizedevidence 5/5Keywords: study set prospectively compares diagnostic accuracy combined ultrasound-doppler-serum - Age-male-albumin-bilirubin-platelet score stratifies hepatocellular carcinoma risk after sustained virological response in hepatitis C-related compensated advanced chronic liver disease (2026) · World Journal of Hepatology · doi
Across this set, the diagnostic performance of ultrasound-based and serum-based fibrosis assessment is reported for cirrhosis and HCC prediction (papers 1, 3, 9, 10) or for advanced fibrosis in NASH and CHB (papers 4, 5, 7), but no prospective study stratifies fibrosis stages (F0–F4 by METAVIR or Ishak) in chronic hepatitis C using a combined ultrasound-Doppler-serum panel at a tertiary center, limiting evidence for stage-specific accuracy in this population.
generalsynthesizedevidence 5/5Keywords: across set diagnostic performance ultrasound-based serum-based fibrosis assessment
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