Overcoming the highly organized structure of the stratum

The gap

Evidence profile

Sourced from the stated challenges and stated research gap of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 3 representative gaps

• Fabrication and Characterization of Benzhydroxamic Acid-Loaded Dissolving Microneedles Using a 3D-Printing-Assisted Mold Fabrication Approach (2026) · Micromachines · doi

  Overcoming the highly organized structure of the stratum corneum for transdermal drug delivery. Achieving sufficient needle length and tip sharpness for insertion. Providing adequate structural support for the microneedles.

  generalstated challenges
  Keywords: overcoming highly organized structure stratum corneum transdermal drug
• DESIGN AND OPTIMIZATION OF TRANSDERMAL PATCHES OF TELMISARTAN USING FACTORIAL DESIGN FOR SUSTAINED DRUG RELEASE: A REVIEW (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi

  Conventional oral dosage forms may exhibit limitations such as variable gastrointestinal absorption and hepatic first-pass metabolism. The skin presents a significant barrier to drug permeation, particularly due to the stratum corneum.

  generalstated research gapevidence 5/5
  Keywords: conventional oral dosage forms exhibit limitations variable gastrointestinal
• In vivo spatiotemporal fate of nanoparticle-incorporated dissolving microneedles: nanoparticle size effects (2026) · Drug Delivery and Translational Research · doi

  The lack of efficient transdermal drug delivery methods that can overcome the stratum corneum barrier. The need for novel approaches that can provide improved transdermal drug delivery efficiency. The limitations of traditional TDDs, including skin irritation and equipment dependence.

  generalstated research gapevidence 5/5
  Keywords: lack efficient transdermal drug delivery methods overcome stratum

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