How many papers support this gap analysis?

3 papers from our local library contribute to this synthesis, with an average publication year of 2026.

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biology3 papersavg year 2026weak evidence

Phage resistance systems and immunogenicity are obstacles

Research gap analysis derived from 3 biology papers in our local library.

The gap

Phage resistance systems and immunogenicity are obstacles to clinical implementation. The regulatory problem of using genetically modified phages in a therapeutic way needs closer examination. The study does not provide a comprehensive anal

Evidence profile

Sourced from the future-work section and limitations section of the source papers, classified as general, spanning 3 journals.

Research trend

Established — well-defined area with open sub-problems.

Supporting evidence — 4 representative gaps

Engineering CRISPR-Cas13 Armed Bacteriophages to Combat Carbapenem Resistant Klebsiella pneumonia: A Targeted Antimicrobial Approach for Pakistan (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
Future studies should focus on creating enhanced delivery systems for CRISPR-Cas13 armed bacteriophages. Future studies should evaluate the synergistic action of phages and CRISPR-Cas13 systems in clinical trials. Future studies should overcome the question of the safety and effectiveness of phage CRISPR therapies.
generalfuture-work section
Keywords: future studies focus creating enhanced delivery systems crispr-cas13
Engineering CRISPR-Cas13 Armed Bacteriophages to Combat Carbapenem Resistant Klebsiella pneumonia: A Targeted Antimicrobial Approach for Pakistan (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
Phage resistance systems and immunogenicity are obstacles to clinical implementation. The regulatory problem of using genetically modified phages in a therapeutic way needs closer examination. The study does not provide a comprehensive analysis of the safety and effectiveness of phage CRISPR therapies.
generallimitations section
Keywords: phage resistance systems immunogenicity obstacles clinical implementation regulatory
CRISPR-based screening of host factors in veterinary viral infections: from target discovery to host-directed antiviral strategies (2026) · Frontiers in Veterinary Science · doi
Further studies are needed to establish the physiological relevance of CRISPR screening findings to infection in primary porcine macrophages. The development of host-directed antiviral strategies using CRISPR/Cas9-based screening. The generation of disease-resistant livestock through precise genome editing.
generalfuture-work sectionevidence 5/5
Keywords: further studies needed establish physiological relevance crispr screening
Antimicrobial Resistance: The Silent Evolution of Superbugs and the Microbial Technologies Fighting Back (2026) · Vigyaksha · doi
The development of new antimicrobial compounds and therapies, - The exploration of new approaches such as bacteriophage therapy and CRISPR-based antimicrobials, - The promotion of responsible prescribing and sustainable antimicrobial stewardship, - The emphasis on the One Health approach to control resistance
generalfuture-work sectionevidence 5/5
Keywords: development new antimicrobial compounds therapies exploration approaches bacteriophage

Questions about this gap

Phage resistance systems and immunogenicity are obstacles to clinical implementation. The regulatory problem of using genetically modified phages in a therapeutic way needs closer… This is supported by 4 representative gap statements extracted from 3 papers, rated weak evidence.

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