The absence of a practical, versatile radical glycosyl donor suitable for modular cross-coupling

The gap

Evidence profile

Sourced from the stated research gap and limitations section and abstract of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 4 representative gaps

• C-glycoside synthesis via radical cross-coupling of glycohydrazides (2026) · Nature · doi

  the absence of a practical, versatile radical glycosyl donor suitable for modular cross-coupling. the need for efficient and scalable synthetic strategies to access diverse C-aryl glycoside architectures. the lack of a general, programmable approach to stereoselective RCC.

  generalstated research gapevidence 5/5
  Keywords: absence practical versatile radical glycosyl donor suitable modular
• Stirring glycopeptides away from the constraints of solid-phase synthesis misconceptions (2026) · Frontiers in Molecular Biosciences · doi

  The inability to efficiently synthesize glycopeptides using state-of-the-art solid-phase peptide synthesis. The lack of a method that can accelerate the synthesis of glycopeptides while maintaining good crude purity. The need for a new approach that can overcome the limitations of traditional solid-phase peptide synthesis.

  generalstated research gapevidence 5/5
  Keywords: inability efficiently synthesize glycopeptides using state-of-the-art solid-phase peptide
• Stirring glycopeptides away from the constraints of solid-phase synthesis misconceptions (2026) · Frontiers in Molecular Biosciences · doi

  Obtaining GP libraries is limited by the inherent synthetic difficulties, - The assembly of glycopeptide libraries that manifest the variety of glycosylation is required, - The type of the core, the specific extension and modification of the glycan combines with the multiple glycosylations sites, their heterogeneity and the co-existence with other PTMs to set a vast synthetic challenge

  generallimitations sectionevidence 5/5
  Keywords: obtaining libraries limited inherent synthetic difficulties assembly glycopeptide
• Stereodivergent C ‐(Hetero)Aryl Glycosylation by Nickel‐Catalyzed Redox‐Neutral Cross‐Coupling of Glycosyl Sulfonyl Hydrazides (2026) · Angewandte Chemie International Edition · doi

  Despite past advances in C ‐glycosylation, methods that provide selective access to both α and β anomers are scarce due to the challenge of controlling stereoselectivity.

  generalabstractevidence 4/5
  Keywords: despite past advances glycosylation provide selective access anomers scarce challenge controlling stereoselectivity

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