The diagnostic results from ultrasound examinations

The gap

Evidence profile

Stated in the future work and cells research gap sections of the source papers, classified as general, spanning 3 journals.

Supporting evidence — 3 representative gaps

• CACA technical guidelines for ultrasound imaging diagnosis of thyroid tumors (2026) · Holistic Integrative Oncology · doi

  This guideline establishes a standardized and integra- tive framework for the ultrasound-based management of thyroid tumors. It encompasses conventional imag- ing, refined TI-RADS stratification, advanced techniques such as contrast-enhanced ultrasound and elastography, and evidence-based recommendations for ultrasound- guided fine-needle aspiration biopsy. By harmoniz- ing imaging protocols and decision-making pathways, the guideline aims to enhance diagnostic consistency, optimize risk assessment, and promote precise clinical management. Wei et al. Holistic Integrative Oncology (2026) 5:51 Page 7 of 8 Looking ahead, the integration of artificial intelligence for automated nodule detection and characterization, the development of molecular and contrast-enhanced ultrasound biomarkers for noninvasive risk prediction, and the refinement of elastographic and fusion imaging techniques hold promise for further improving diag- nostic accuracy and personalizing therapeutic strategies [19–21]. The continuous evolution of these technologies, coupled with multi-institutional validation and guideline updates, will support more proactive, individualized, and minimally invasive approaches to thyroid nodule evalua- tion and care. These advances are expected to strengthen the role of ultrasound in thyroid tumor management and contribute to better patient outcomes. Authors’ contributions XW: Conceptualized and designed the study, led the literature retrieval and analysis, drafted the manuscript, critically reviewed the intellectual content, oversaw overall project management and coordination, critically reviewed the intellectual content, acquired funding, provided administrative, technical, or material support. AL, WW, XJ, JW, ML, WC, PL, QL, YW, JZ, JZ: Contributed to the conception and design of the study, critically reviewed the intellectual content, assisted in literature retrieval, provided valuable suggestions on the article structure, and contributed to multiple revisions and editing of the manuscript. All authors have read and approved the manuscript.

  generalstated in future workevidence 5/5
  Keywords: ultrasound management guideline thyroid manuscript critically reviewed intellectual content based techniques contrast enhanced imaging risk
• Development and clinical validation of an artificial intelligence based model for thyroid nodule malignancy risk assessment using C-TIRADS guidelines (2026) · Frontiers in Medicine · doi

  The diagnostic results from ultrasound examinations are often subjective, labor-intensive, and highly dependent on the clinical experience of the ultrasound physician. - There is a need for a standardized and accurate method for assessing the benign or malignant nature of thyroid nodules. - The proposed model aims to address this gap by providing a C-TIRADS-guided computer-aided diagnostic framework.

  generalstated in cells research gapevidence 5/5
  Keywords: diagnostic results ultrasound examinations often subjective labor-intensive highly
• Development and validation of a multimodal predictive model based on clinical, biochemical, and quantitative dual-energy CT parameters: for predicting the benignity and malignancy of thyroid nodules (2026) · Frontiers in Endocrinology · doi

  There is a need for a more accurate diagnostic approach to differentiate benign from malignant thyroid nodules. - The current diagnostic approach has limitations, including the use of fine-needle aspiration biopsy (FNAB) with indeterminate results. - There is a gap in the literature regarding the integration of clinical, biochemical, and quantitative dual-energy CT parameters for thyroid cancer diagnosis.

  generalstated in cells research gapevidence 5/5
  Keywords: there need accurate diagnostic approach differentiate benign malignant

Questions about this gap