The effect of specific probiotic strains should be investigated to understand better the influence the have on the gut microbiota

The gap

Evidence profile

Sourced from the conclusions and recommendations and inline gaps of the source papers, classified as general, drawn from work published between 2025 and 2026, spanning 2 journals. Those papers have been cited 7 times in total.

Supporting evidence — 4 representative gaps

• The impact of exercise and probiotic supplementation on the gut microbiota and management of gestational diabetes mellitus: a critical review (2026) · Critical Reviews in Food Science and Nutrition · doi

  The effect of specific probiotic strains should be investigated to under- stand better the influence the have on the gut microbiota. The relationship between the gut microbiota, exercise, probi- otics and glycemic control also needs to be explored in depth. In particular the mechanisms whereby Bifidobacterium, Lactobacillus, and Bacteroides influence the gut microbiota warrant further investigation as these have been found to be reduced during pregnancy (Chen et  al.

  generalconclusions
  Keywords: microbiota influence effect specific probiotic strains investigated stand better relationship exercise probi otics glycemic control
• The impact of exercise and probiotic supplementation on the gut microbiota and management of gestational diabetes mellitus: a critical review (2026) · Critical Reviews in Food Science and Nutrition · doi

  The potential health benefits of probiotics and exercise can- not be overlooked in the management and prevention of Amirani E, Asemi Z, Taghizadeh M. 2022. The effects of selenium plus probiotics supplementation on glycemic status and serum lipopro- teins in patients with gestational diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Clin Nutr ESPEN. 48:56–62. https://doi.org/10.1016/j.clnesp.2022.02.010 Artal R, Catanzaro RB, Gavard JA, Mostello DJ, Friganza JC. 2007. A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus. Appl Physiol Nutr Metab. 32(3):596–601. https://doi.org/10.1139/H07-024 Asgharian H, Homayouni-Rad A, Mirghafourvand M, Mohammad- Alizadeh-Charandabi S. 2020. Effect of probiotic yoghurt on plasma glucose in overweight and obese pregnant women: a randomized controlled clinical trial. Eur J Nutr. 59(1):205–215. https://doi.org/ 10.1007/s00394-019-01900-1 Barakat R, Cordero Y, Coteron J, Luaces M, Montejo R. 2012. Exercise during pregnancy improves maternal glucose screen at 24–28 weeks: a randomised controlled trial. Br J Sports Med. 46(9):656–661. https://doi.org/10.1136/bjsports-2011-090009 Barakat R, Refoyo I, Coteron J, Franco E. 2019. Exercise during preg- nancy has a preventative effect on excessive maternal weight gain and gestational diabetes. A randomized controlled trial. Braz J Phys Ther. 23(2):148–155. https://doi.org/10.1016/j.bjpt.2018.11.005 Callaway LK et al. 2019. Probiotics for the prevention of gestational diabetes mellitus in overweight and obese women: findings from the SPRING double-blind randomized controlled trial. Diabetes Care. 42(3):364–371. https://doi.org/10.2337/dc18-2248 Campaniello D et al. 2022. How diet and physical activity modulate gut microbiota: evidence, and perspectives. Nutrients. 14(12):2456. https://doi.org/10.3390/nu14122456 8 M. c. GRANt Chen J et al. 2022. Relationship between gut microbiome characteristics and the effect of nutritional therapy on glycemic control in pregnant women with gestational diabetes mellitus. PLoS One. 17(4):e0267045. https://doi.org/10.1371/journal.pone.0267045 Colberg SR, Castorino K, Jovanovič L. 2013. Prescribing physical activ- ity to prevent and manage gestational diabetes. World J Diab. 4(6):256–262. https://doi.org/10.4239/wjd.v4.i6.256 Cordero Y, Mottola MF, Vargas J, Blanco M, Barakat R. 2015. Exercise is associated with a reduction in gestational diabetes mellitus. Med Sci Sports Exerc. 47(7):1328–1333. https://doi.org/ 10.1249/MSS.0000000000000547 de Barros MC, Lopes MA, Francisco RP, Sapienza AD, Zugaib M. 2010. Resistance exercise an

  generalrecommendations
  Keywords: https diabetes gestational exercise mellitus controlled trial randomized women probiotics nutr obese effect barakat prevention
• Lactiplantibacillus plantarum Probio87 supplementation improves functional constipation and is associated with peripheral gene-expression responses related to inflammation and the gut–brain axis: a randomized, double-blind, placebo-controlled trial (2026) · Frontiers in Nutrition · doi

  To minimize potential confounding from diet and lifestyle, all participants received standardized lifestyle recommendations throughout the study. These included a daily breakfast containing approximately 50 g of oats as a practical dietary-fiber source, water intake of at least 1,500 mL/day, and at least 30 min/day of brisk walk- ing. These recommendations were uniformly applied to both probiotic and placebo groups. Adherence was monitored using participant dia- ries and returned sachet counts. However, detailed dietary intake was not quantitatively recorded, which is acknowledged as a limitation. 2.3 Study protocol 2.5 Safety monitoring This was a double-blind, randomized, placebo-controlled trial. Randomization was conducted upon considering the inclusion and exclusion criteria. Qualified participants were randomized according to a 1:1 ratio to the two arms of the study according to a computer- generated list, assigned to the probiotic or placebo group with 2.5.1 Strain genomic safety: virulence and resistance genes Genomic DNA of Lactiplantibacillus plantarum Probio87 was extracted using the STE method. The integrity of the extracted DNA

  generalrecommendations
  Keywords: placebo lifestyle participants recommendations dietary intake least probiotic using safety randomized according genomic extracted minimize
• Probiotics supplements for the prevention of atopic dermatitis in children: an umbrella review (2025) · Frontiers in Nutrition · cited 7× · doi

  Future research should focus on exploring synergistic dietary intervention strategies that combine probiotics with other dietary components to optimize the management of AD. Moreover, some studies have suggested that supplementation with dietary fats (such as gamma-linolenic acid, docosahexaenoic acid, and arachidonic acid), vitamins and pancreatic enzymes and may also exert beneficial effects on the incidence of AD in infants (97–101), although the evidence remains limited and the efficacy requires further investigation.

  generalinline gaps
  Keywords: dietary acid future focus exploring synergistic intervention strategies combine probiotics components optimize management supplementation fats

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