The evidence base is limited by small sample sizes, inconsistent reporting of baseline tooth characteristics, and variability
Research gap analysis derived from 3 medicine papers in our local library.
The gap
The evidence base is limited by small sample sizes, inconsistent reporting of baseline tooth characteristics, and variability in RET protocols and imaging modalities. Restricting inclusion to RCTs improved internal validity but reduced the number of eligible studies.
Evidence profile
Sourced from the limitations and stated challenges and recommendations of the source papers, classified as general, spanning 3 journals. Those papers have been cited 1 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 3 representative gaps
- From blood to biology: evaluating platelet-rich plasma as a scaffold in regenerative endodontics — a systematic review (2026) · Journal of Baghdad College of Dentistry · doi
The evidence base is limited by small sample sizes, inconsistent reporting of baseline tooth characteristics, and variability in RET protocols and imaging modalities. Restricting inclusion to RCTs improved internal validity but reduced the number of eligible studies. Meta-analysis was not possible because of substantial heterogeneity, and publication bias could not be meaningfully assessed with fewer than ten studies.
generallimitationsevidence 5/5Keywords: evidence base limited small sample sizes inconsistent reporting baseline tooth characteristics variability protocols imaging modalities - Statistical errors and reporting deficiencies in clinical prosthodontic publications, 2019–2024 (2026) · Journal of Prosthodontics · cited 1× · doi
The study faced challenges in ensuring the representativeness of the sample, given the restriction to English-language, high-impact journals. The study also faced challenges in evaluating the appropriateness, application, and reporting of statistical tests, given the complexity of statistical analysis in prosthodontic research. The study identified the need for greater involvement of statisticians in the research process to improve methodological rigor and clinical relevance.
generalstated challengesevidence 5/5Keywords: study faced challenges ensuring representativeness sample given restriction - Statistical Reporting Quality in Physical Medicine and Rehabilitation Journals: A Comparative Analysis of SCI-E and TR Indexed Publications (2026) · The Eurasian Journal of Medicine · doi
statistical for reporting in biomedical journals. Clin Med (Lond). 2025;25(3):100304. [CrossRef] improving 18. Nour-Eldein H. Statistical methods and errors in family medicine articles between 2010 and 2014-Suez Canal University, Egypt: a cross-sec- tional study. J Fam Med Prim Care. 2016 5(1):24- 33. [CrossRef] 19. Nieminen P, Vähänikkilä H. Use of data analysis methods in dental publications: is there evidence of a methodological change? Publications. 2020;8(1):9. [CrossRef]. 23. Nakagawa S, Cuthill IC. Effect size, confidence interval and statistical significance: a practical guide for biologists. Biol Rev Camb Philos Soc. 2007;82(4):591-605. [CrossRef] Erratum in: Biol Rev Camb Philos Soc. 2009;84(3):515. 24. Moher D, Schulz KF, Altman D, CONSORT Group (Consolidated Standards of Reporting Trials). The CONSORT statement: revised rec- ommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285(15):1987-1991. [CrossRef] Ioannidis JP. Why most published research find- false. PLOS Med. 2005;2(8):e124. ings are [CrossRef] PLOS Med. in: 2022;19(8):e1004085. 10.1371/journal. pmed.1004085
generalrecommendationsevidence 5/5Keywords: crossref statistical reporting improving publications biol camb philos consort group trials plos biomedical journals clin
Questions about this gap
Explore this gap further
Run this gap as a query across open scholarly engines for the latest related literature.
Working on this gap? Review it with us.
AI Review reads your manuscript in one pass with 8 specialist agents, calibrated on 69K+ real peer reviews.
Tools for your next paper
Related gaps in Medicine
- The variability in patient response to different splintThe variability in patient response to different splint designs, which can affect the clinical outcomes. Another challenge is the need for…
- Future high-quality clinical trials are neededFuture high-quality clinical trials are needed to validate and refine these strategies for more precise and effective patient treatments.
- This is not a systematic review or meta-analysisThis is not a systematic review or meta-analysis; thus, it does not provide quantitative comparisons of therapeutic efficacy.
- External validation is required before the modelExternal validation is required before the model can be applied in clinical settings.