The need for efficient and sustainable extraction methods
Research gap analysis derived from 6 chemistry papers in our local library.
The gap
The need for efficient and sustainable extraction methods for phytochemicals. - The limited understanding of the advantages and limitations of emerging extraction techniques.
Evidence profile
Stated in the recommendations and cells research gap and cells future research and discussion sections of the source papers, classified as general, spanning 6 journals.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 7 representative gaps
- Acetone-Based Comparative Phytochemical Profiling of Indonesian Ethnomedicinal Plants: Effects of Maceration and Soxhlet Extraction (2026) · JURNAL SURYA TEKNIKA · doi
(a) compound quantification via HPLC-DAD and LC-MS/MS; (b) validated in vitro bioactivity assays (DPPH, MIC, MTT assay); (c) bioactivity-guided fractionation; (d) OECD 423 acute toxicity testing before formulation development. include REFERENCES H. J. Woerdenbag and O. Kayser, "Jamu: Indonesian traditional rational phytopharmacological use," J. Herb. Med., vol. 4, no. 2, pp. 51–73, 2014. herbal medicine towards N. N. Azwanida, "A review on the extraction methods used in medicinal plants: principle, strength and limitation," Med. Aromat. Plants, vol. 4, no. 196, 2015. M. D. L. De Castro and F. Priego-Capote, "Soxhlet extraction: Past and present panacea," J. Chromatogr. A, vol. 1217, no. 16, pp. 2383–2389, 2010. S. Sun et al., "Impact of extraction techniques on phytochemical composition and bioactivity of natural product mixtures," Front. Pharmacol., vol. 16, art. 1615338, 2025. L. G. M. da Silva et al., "Synergy between solvent polarity and composition for efficient extraction of bioactive compounds from pitaya," Food Mater. Res., vol. 5, no. 1, 2025. M. Naczk and F. Shahidi, "Phenolics in cereals, fruits and vegetables: Occurrence, extraction and analysis," J. Pharm. Biomed. Anal., vol. 41, no. 5, pp. 1523– 1542, 2006. C. Reichardt and T. Welton, Solvents and Solvent Effects in Organic Chemistry. Hoboken, NJ, USA: John Wiley & Sons, 2011. A. J. Harborne, Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. Dordrecht, Netherlands: Springer Science & Business Media, 1998. W. C. Evans, Trease and Evans Pharmacognosy, 15th ed. India: Saunders/Elsevier Science, 2002. A. E. Sofowara, Medicinal Plants and Traditional Medicine in Africa, vol. 2. Ibadan, Nigeria: Spectrum Books Ltd., 1993. K. S. Sim, A. M. Sri Nurestri, and A. W. Norhanom, "Phenolic content and antioxidant activity of crude and fractionated extracts of Pereskia bleo (Kunth) DC. (Cactaceae)," African J. Pharm. Pharmacol., vol. 4, no. 5, pp. 193–201, 2010. S. Zareisedehizadeh, C.-H. Tan, and H.-L. Koh, "A review of botanical characteristics, traditional usage, chemical components, pharmacological activities, and safety of Pereskia bleo (Kunth) DC.," Evidence-Based Complement. Altern. Med., vol. 2014, art. 326107, 2014. R. M. P. Gutierrez, S. Mitchell, and R. V. Solis, "Psidium guajava: A review of its traditional uses, phytochemistry J. Ethnopharmacol., vol. 117, no. 1, pp. 1–27, 2008. pharmacology," and Z. Khan, D. Shahwar, M. K. Y. Ansari, and R. Chandel, "Toxicity assessment of anatase (TiO2) nanoparticles: A pilot study on stress response alterations and DNA damage studies in Lens culinaris Medik.," Heliyon, 2019. I. T. Fu’adah, S. A. Sumiwi, and G.
generalstated in recommendationsevidence 5/5Keywords: extraction traditional bioactivity review plants toxicity medicine medicinal techniques phytochemical composition pharmacol solvent pharm science - Extraction techniques for phytochemicals: Conventional and emerging methods (2026) · Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas · doi
The need for efficient and sustainable extraction methods for phytochemicals. - The limited understanding of the advantages and limitations of emerging extraction techniques.
generalstated in cells research gapevidence 5/5Keywords: need efficient sustainable extraction methods phytochemicals limited understanding - DETERMINE THE BEST CONDITIONS FOR EXTRACTING BIOATIVE COMPOUNDS FROM ROSMARINUS OFFICINALIS LEAVES (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi
Further studies can be conducted to develop more effective extraction methods for bioactive compounds. - The biological activity of extracts can be tested against other types of pathogens.
generalstated in cells future researchevidence 5/5Keywords: further studies conducted develop effective extraction methods bioactive - Acetone-Based Comparative Phytochemical Profiling of Indonesian Ethnomedicinal Plants: Effects of Maceration and Soxhlet Extraction (2026) · JURNAL SURYA TEKNIKA · doi
Systematic comparisons of extraction techniques remain limited. - Acetone has rarely been applied as a single solvent in comparative phytochemical studies of Indonesian medicinal plants.
generalstated in cells research gapevidence 5/5Keywords: systematic comparisons extraction techniques remain limited acetone has - Effect of different solvent on phytochemical content of Moringa oleifera L. leaves. (2026) · International Journal of Life Science Research Archive · doi
Further studies can be conducted to evaluate the antioxidant activity of the extracted phytochemicals. - The study's findings can be used to develop effective extraction methods for phytochemicals from Moringa oleifera L. leaves.
generalstated in cells future researchevidence 5/5Keywords: further studies conducted evaluate antioxidant activity extracted phytochemicals - Determination of essential oil composition of Laurencia obtusa and Ceramium spp. in Black Sea and antileishmanial activity (2026) · International Journal of Secondary Metabolite · doi
Further research is needed to confirm the findings and to evaluate the in vivo efficacy of the extracts. - The study suggests the potential for controlled experiments in laboratory animals to assess MIC values and to optimize dosage for therapeutic use. - The study implies that future research should focus on correlation-based evaluations using isolated compounds, detailed cytotoxicity analyses, and comprehensive in vivo assessments.
generalstated in cells future researchevidence 5/5Keywords: further research needed confirm findings evaluate vivo efficacy - The analysis of sodium butyrate content in various dietary supplements available on the Polish market (2026) · Annales Academiae Medicae Silesiensis · doi
Due to the unique nature of the method used, data on the potential impact of these substances on the extraction efficiency and chromatography result are limited. Further research in this area is warranted to enhance the quality control and safety of dietary supplements.
generalstated in discussionevidence 4/5Keywords: unique nature used potential impact substances extraction efficiency chromatography result limited further area warranted enhance
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