The need for novel antimicrobial agents to combat

The gap

Evidence profile

Sourced from the future work and future-work section and stated research gap and abstract and conclusions of the source papers, classified as general, drawn from work published between 2002 and 2026, spanning 7 journals.

Supporting evidence — 8 representative gaps

• Tri-Herbal Alchemy: Green Synthesis of Silver Nanoparticles from Amalaki, Bibhitaki, and Haritaki for Antibacterial Applications (2026) · International Journal of Drug Delivery Technology · doi

  Biogenically exhibit significant potential across numerous industries, especially in biomedical applications, owing to their strong antibacterial and antioxidant capabilities. Their effectiveness can be evaluated by techniques such as agar disc diffusion and serial dilution. Nanoparticles can function as economical antibacterial agents, with prospective applications in medical, pharmaceuticals, and extensive industrial manufacturing. Their compatibility with medicinal applications, along with ease of synthesis and environmental sustainability, renders them ideal candidates for the development of new treatments and industrial products. IJDDT, Volume 16 Issue 18s, 2026 Page 23 Tri-Herbal Alchemy: Green Synthesis of Silver Nanoparticles from Amalaki, Bibhitaki, and Haritaki for Antibacterial Applications. and 29. Khan, F., Shukla, R., & Soni, V. (2017). Nanotechnology in medicine: Applications and challenges. Materials Science and Engineering C, 76, 1336-1343. 30. Kumar, B., Verma, S., & Singh, M. (2019). Silver nanoparticles as antimicrobial agents: A review on recent patents. Recent Patents on Nanotechnology, 13(1), 35-45. 31. Patra, J. K., & Baek, K. H. (2014). Green biomedical nanotechnology: Synthesis applications of silver nanoparticles. Advanced Drug Delivery Reviews, 72, 57-70. 32. Sharma, V. K., Yngard, R. A., & Lin, Y. (2019). Silver nanoparticles: Green synthesis and their antimicrobial activities. Advances in Colloid and Interface Science, 145(1), 83- 33. Singh, R. P., Ramarao, P., & Das, M. (2018). Silver nanoparticles in biomedical applications: Progress and challenges. Trends in Biotechnology, 35(3), 246-258. 34. Verma, A., & Mehata, M. S. (2016). Controlling the synthesis of silver nanoparticles with plant extracts. Materials Science and Engineering C, 58, 36-43.

  generalfuture workevidence 5/5
  Keywords: applications nanoparticles silver synthesis biomedical antibacterial green nanotechnology science agents industrial challenges materials engineering verma
• Callus-derived silver nanoparticles from myrmecodia tuberosa: green synthesis and antioxidant properties (2026) · Lentera Negeri · doi

  To optimize the conditions for callus induction and silver nanoparticle synthesis. To evaluate the potential applications of the synthesized nanoparticles in biomedical practices. To explore the use of other plant-based materials for the green synthesis of silver nanoparticles.

  generalfuture-work sectionevidence 5/5
  Keywords: optimize conditions callus induction silver nanoparticle synthesis evaluate
• SYNTHESIS OF CLOXACILLIN@AG NANOPARTICLES WITH ENHANCED ANTIBACTERIAL ACTIVITY BY PHOTO-REDUCTION METHOD (2026) · İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi · doi

  The need for new therapeutics to combat antimicrobial resistance. The lack of understanding of the mechanisms of action of silver nanoparticles. The limited evaluation of the in vivo toxicity profile of silver nanoparticles.

  generalstated research gapevidence 5/5
  Keywords: need new therapeutics combat antimicrobial resistance lack understanding
• Green Synthesis and Characterization of Propiconazole-Conjugated Silver Nanoparticles Using Elephant Urine and Their Antifungal Activity Against Colletotrichum gloeosporioides (2026) · Journal of Chemical Health Risks · doi

  The conventional synthesis methods of silver nanoparticles often generate environmentally harmful by-products. There is a need to develop safe, stable, and environmentally sustainable synthesis methods. The use of elephant urine as a biological reducing and stabilizing agent can address this gap.

  generalstated research gapevidence 5/5
  Keywords: conventional synthesis methods silver nanoparticles often generate environmentally
• Antioxidant, Antibacterial and Antifungal Activities of Silver Nanoparticle Synthesized from Spirulina Platensis (2026) · BioNanoScience · doi

  The need for novel antimicrobial agents to combat life-threatening infections. The limited exploration of the use of Spirulina platensis extract for the green synthesis of silver nanoparticles.

  generalstated research gapevidence 5/5
  Keywords: need novel antimicrobial agents combat life-threatening infections limited
• Antioxidant, Antibacterial and Antifungal Activities of Silver Nanoparticle Synthesized from Spirulina Platensis (2026) · BioNanoScience · doi

  Further evaluation of the antioxidant, antibacterial, and antifungal activities of silver nanoparticles synthesized using different plant extracts. Investigation of the potential applications of these nanoparticles in medicine and other fields. Exploration of the mechanisms underlying the antimicrobial activity of silver nanoparticles.

  generalfuture-work sectionevidence 5/5
  Keywords: further evaluation antioxidant antibacterial antifungal activities silver nanoparticles
• Assessment of Antibacterial Activities of Silver Nanoparticles Biosynthesized Using Loranthus Micranthus Leaf and Nigella Sativa Seed Extracts on Selected Uropathogens (2002) · IALLT Journal of Language Learning Technologies · doi

  Despite the growing interest in biosynthesized silver nanoparticles (AgNPs), there is insufficient research information on the use of Loranthus micranthus leaf and Nigella sativa seed extracts for AgNPs biosynthesis.

  generalabstractevidence 4/5
  Keywords: agnps despite growing interest biosynthesized silver nanoparticles there insufficient information loranthus micranthus leaf nigella sativa
• Agave americana leaf extract-mediated green synthesis of silver nanoparticles: physicochemical characterization, antibacterial activity, antioxidant capacity, and cytotoxicity toward SiHa cells (2026) · Health Nanotechnology · doi

  Overall, the work supports Agave americana-derived silver nanoparticles as a promising platform for antimicrobial and anticancer applications, while future studies should focus on mechanistic conrmation, biosafety, and translational evaluation. However, the study is limited by the absence of direct reactive oxygen species quantication, apoptosis-marker analysis, and in vivo validation, so the proposed mechanisms should be interpreted as preliminary.

  generalconclusionsevidence 3/5
  Keywords: overall supports agave americana derived silver nanoparticles promising platform antimicrobial anticancer applications future focus mechanistic

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