The need for novel solvents that are highly efficient for extraction, affordable, and environmentally benign
Research gap analysis derived from 7 chemistry papers in our local library.
The gap
The paper identifies the need for novel solvents that are highly efficient for extraction, affordable, and environmentally benign. The authors highlight the limitations of conventional solvents used for PCs extraction, including their negative environmental impacts.
Evidence profile
Sourced from the stated research gap and future-work section and stated challenges of the source papers, classified as general, drawn from work published between 2017 and 2026, spanning 5 journals. Those papers have been cited 43 times in total.
Research trend
Established — well-defined area with open sub-problems.
Supporting evidence — 7 representative gaps
- Hydrophobic deep eutectic solvent based on choline chloride and octanoic acid for phenolic compounds separation: experimental investigation and DFT analysis (2026) · Chemical Papers · doi
The paper identifies the need for novel solvents that are highly efficient for extraction, affordable, and environmentally benign. The authors highlight the limitations of conventional solvents used for PCs extraction, including their negative environmental impacts.
generalstated research gapKeywords: paper identifies need novel solvents highly efficient extraction - Tailoring Garlic Bioactive Profiles Through Green Extraction: Comparative Optimization of Microwave- and Ultrasound-Assisted Technologies (2026) · Molecules · doi
Further research is needed to optimize the extraction conditions for maximizing antioxidant activity, - Investigation of other extraction methods and their effects on bioactive compounds, - Study of the effects of extraction parameters on the stability of garlic bioactive compounds
generalfuture-work sectionKeywords: further research needed optimize extraction conditions maximizing antioxidant - Topical anti-inflammatory activity test and identification of anti-inflammatory active compounds of ether extract of stem bark and leaves resin of tenggulun protium javanicum burm (2017) · International Journal of Current Advanced Research · cited 1× · doi
It is difficult to separate the fatty acids perfectly although a non-polar solvent hexane was used in excess. The purification becomes perfect when the right method to separate the fatty acids contained is found. The need to identify the anti-inflammatory active compounds in the extract.
generalstated challengesevidence 5/5Keywords: difficult separate fatty acids perfectly although non-polar solvent - Antioxidant, Antithrombotic and Anti-Inflammatory Properties of Amphiphilic Bioactives from Water Kefir Grains and Its Apple Pomace-Based Fermented Beverage (2025) · Antioxidants · cited 17× · doi
The paper identifies technical challenges such as the need to optimize the extraction and separation techniques to analyze the bioactive compounds. The study also highlights the challenge of evaluating the anti-inflammatory and antithrombotic activity of the bioactive compounds against human platelet aggregation.
generalstated challengesevidence 5/5Keywords: paper identifies technical challenges need optimize extraction separation - Advances in Natural Product Extraction: Established and Emerging Technologies (2026) · Molecules · cited 15× · doi
The gap in conventional extraction techniques, such as maceration and Soxhlet extraction, is their limited efficiency and potential for compound degradation. The need for more efficient and selective extraction methods is identified. The potential of green solvents and advanced technologies to address this gap is discussed.
generalstated research gapevidence 5/5Keywords: gap conventional extraction techniques maceration soxhlet limited efficiency - Deep Eutectic Solvent Systems as Media for the Selective Extraction of Anti-Inflammatory Bioactive Agents (2025) · Molecules · cited 10× · doi
The lack of efficient and sustainable methods for extracting anti-inflammatory bioactive compounds. The need for green extraction technologies that can replace conventional methods. The limited understanding of the relationship between solvent selection, extraction techniques, and the efficiency of anti-inflammatory molecule extraction.
generalstated research gapevidence 5/5Keywords: lack efficient sustainable methods extracting anti-inflammatory bioactive compounds - Phytochemical Profile and In Vivo Assessment of Toxicity and Anti-Inflammatory Activity of Cenostigma pluviosum var. peltophoroides (Benth.) Gagnon & G.P. Lewis (2026) · Plants · doi
further studies are needed to investigate the long-term effects of the extract, - studies should be conducted to isolate and characterize the individual compounds responsible for the anti-inflammatory activity, - research should be done to evaluate the potential of the extract as a therapeutic agent
generalfuture-work sectionevidence 4/5Keywords: further studies needed investigate long-term effects extract conducted
Questions about this gap
Explore this gap further
Run this gap as a query across open scholarly engines for the latest related literature.
Working on this gap? Review it with us.
AI Review reads your manuscript in one pass with 8 specialist agents, calibrated on 69K+ real peer reviews.
Tools for your next paper
Related gaps in Chemistry
- In vivo validation of the observed bioactivity, detailedFuture studies should focus on in vivo validation of the observed bioactivity, detailed molecular docking and mechanistic analyses, and…
- The lack of effective methods to enhanceThe lack of effective methods to enhance the through-plane thermal conductivity of polymer composites. The limitation of prior work in…
- Traditional mechanical recycling methods have provenTraditional mechanical recycling methods have proven insufficient in addressing the significant environmental challenges caused by…
- The importance of solution chemistry in the designThe importance of solution chemistry in the design of synthesis and processing routes for lead halide perovskite thin films and crystals, a…